Perphemnazinum(PERP) with tertiary amino group and benzoyl peroxide (BPO) initiation system

which can be applied in preparing the drug release membrane containing PERP

was studied.The rate of polymerization of methyl methacrylate (MMA) initiated by PERP BPO system was determined

respectively.It was found that the presence of PERP could increase the rate of polymerization and shorten the induction peroid of polymerization.The order of activity of the amines in DMT(N

N dimethyl toluidine)>DMA(N

N-dimethyl aniline)>PERP.The rate equation of MMA polymerization initiated by PERP-BPO was agreed well with the equation of polymerization with redox initiation system.The value of activation energy overall by PERP-BPO was obtained to Ea=41.8kJ/mol which is lower than that of BPO initiated.From the results of the end-group analysis and molecular weight determination

it is proved.That the PEP as an end-group of PMMA.Accordingly

the initiation step includes the addition of PERP radical to monomer and forms the end-group of polymerization.We also have done the relationship between temp exothemicity and time in the course of the polymerization initiated by PERP-BPO sys tem.Based on this result

it is confirm of that the initiation mechanism of PERP-BPO system is similar to that of redox system by DMT-BPO system.The release behavior of PERP from the drug membranes was parsued.It showed that the release of PERP could last at least 20 days.