In order to obtain the inviseid dendrimers with more terminal amino-groups than those of ω

ω'- polyethylene glycol diamine

in the meanwhile to untihze the fine biocompetibi|ity of polyethylene glycol

aseries of polyamidoamine dendrimers with polyethylene glycol core were synthesized by Tomalia’s divergentmethod which invovled a repeated two-step process：(1) exhaustive Micheal addition of ω

ω'-polyethylene glycol diamine as the initiating core

with methyl acrylate and (2) exhaustive amidation of the resulting esters with a large excess of ethylenediamine．The structures of all generations of the dendrimer was identified by FT-IR and elemental analysis

and the numbers of the terminal aminogroups of the integral generations of the dendrimer were determined by potentiometer titration．Although PEG-NH2 and the integral generations had adsorption at ～3300 cm-1 in FT-IR

the half generations did not have．It indicated that all the steps of Micheal addition took place thoroughly On the other hand

the conversion of the half generations into their corresponding integral generations made the adsorption of the ester’s carbonyl at 1735～1740cm-1 disappear

it suggested that the conversion was complete．The results of lemental analysis also affirmed the above discussion．However the data of elemental analysis and potentiometer titration of PEG-5.0 and PEG-6.0 didn’t entirely coincide with their theoretical values

that may be due to the residue of the ingredients such as ethylenediamine which were bundled up by larger generations with more branches and difficult to remove．Except that PEG-1.0 and PEG-2.0 are solids

the other integral generations are viscous．Influences of the integral generations on coagulation and hemolysis were examined

and the results showed that the properties of coagulation and hemolysis of the integral generations of thedandrimer were similar to those of po|yehylene glycot．