Oligomer poly (N-isopropylacrylamide) has been made up with azobisisobuty-ronitrile(AIBN) as initiator and methonal as solvent．Graft copolymer PAA-g-PIPA could be prepared by graft polymerization of PIPA onto the chain of polyallylamine-hydrochloride(PAA) with 3-ethyl-3(3-dimethylaminopropyl

)-carbodiimidehy-drochlorid(EDC) as condensation agent．M icrospheres with size range of 10μm or so could be made of graft copolymer PAA-g-PIPA with glutaraldehyde(GA) as cross-link agent in water/oil system．Antitumer drug adriamycin(AD) can be car-ried on the PAA-g-PIPA microspheres by physical adsorption．In vitro drug re-lease behaviour of drug-carrying PAA-g-PIPA microspheres was examinied by dynamic dialysis technique．Data from dialysis experiment were treated with a computer after setting a methematical model which can provide a quantitative as-sessment of drug release．The drug release rate constant Km of drug—carrying PAA-g-PIPA microspheres were achieved．It has been shown that Km of PAA-g-PIPA microspheres representing the specificity of drug release increased with increasing the temperature in the range of 30—45℃．This indicated that drug release of drug-carrying PAA-g-PIPA microspheres was obviously temperature responsive．