ε-己内酯与D,L-丙交酯ABA型嵌段共聚物合成及作为药物载体的初步评价

宋存先; 冯新德; SONG Cun-xian; FENG Xin-de

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ε-己内酯与D,L-丙交酯ABA型嵌段共聚物合成及作为药物载体的初步评价

研究论文 | 更新时间：2021-03-19

- ε-己内酯与D,L-丙交酯ABA型嵌段共聚物合成及作为药物载体的初步评价
- SYNTHESIS AND EVALUATION OF BIODEGRADABLE ABA TRIBLOCK COPOLYMER OF δ-CAPROLACTONE AND DL-LACTIDE AS DRUG RELEASE DELIVERY
- 高分子学报 1986年第2期页码：108-114
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- 纸质出版日期：1986-4-20，
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宋存先, 冯新德, SONG Cun-xian, FENG Xin-de. ε-己内酯与D,L-丙交酯ABA型嵌段共聚物合成及作为药物载体的初步评价[J]. 高分子学报, 1986,(2):108-114.

SONG Cun-xian, FENG Xin-de. SYNTHESIS AND EVALUATION OF BIODEGRADABLE ABA TRIBLOCK COPOLYMER OF δ-CAPROLACTONE AND DL-LACTIDE AS DRUG RELEASE DELIVERY[J]. Acta Polymerica Sinica, 1986,(2):108-114.
宋存先, 冯新德, SONG Cun-xian, FENG Xin-de. ε-己内酯与D,L-丙交酯ABA型嵌段共聚物合成及作为药物载体的初步评价[J]. 高分子学报, 1986,(2):108-114. DOI：

SONG Cun-xian, FENG Xin-de. SYNTHESIS AND EVALUATION OF BIODEGRADABLE ABA TRIBLOCK COPOLYMER OF δ-CAPROLACTONE AND DL-LACTIDE AS DRUG RELEASE DELIVERY[J]. Acta Polymerica Sinica, 1986,(2):108-114. DOI：

摘要

“活性”中间体PCL-PLA-OAl 关键词:

Abstract

The growing AB block copolymer intermediate (PCL-PLA-OAi ) was extendedwith ethylene oxide at room temperature to form a HO-terminated PEO end-capped prepolymer which reacted with Teyssie catalyst

and replaced its isopropoxy groups toform an active prepolymeraupported catalyst

PCL-PLA-OCH2CH2-OAl . Ithas been proved that this prepolymer-supported catalyst was able to initiate CL polymerization in toluene at 90℃. The ABA triblocg copolymens with different length of segments with biodegradable as well as tough menbrane-forming properties have been synthesized successfully. This new synthetic method would provide a potential pothway from polylactide to form block copolymers with lactones.

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