生物医用高分子材料细胞膜表面功能化的策略与应用

廖宇思; 梁剑箫; 温转; 蔡明泽; 宋张志; 张薿元; 安红维; 王浩

doi:10.11777/j.issn.1000-3304.2024.24039

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生物医用高分子材料细胞膜表面功能化的策略与应用

综述 | 更新时间：2024-09-20

- 生物医用高分子材料细胞膜表面功能化的策略与应用
- Strategies and Applications of Cell Membrane Surface Functionalization of Polymer Materials
- 高分子学报 2024年55卷第5期页码：553-572
- 作者机构：
  
  1.广西医科大学再生医学与医用生物资源开发应用省部共建协同创新中心南宁 530021
  2.国家纳米科学中心中国科学院纳米生物效应与安全性重点实验室北京 100190
- 作者简介：
  
  [ "安红维，女，1986年生. 2011年毕业于河北科技大学，2016年获国家纳米科学中心物理化学专业博士学位；2016~2020年在中国科学院高能物理研究所从事博士后研究. 2021年至今在国家纳米科学中心担任副研究员. 2023年获得国家自然科学基金优秀青年科学基金资助、北京市科技新星. 主要研究方向为体内原位构建自组装多肽纳米药物、多肽药物在荧光术中导航及其在临床转化领域的应用. 在Nat. Commun.， Angew. Chem. Int. Ed.， JACS， Adv. Mater.， ACS Nano等期刊上发表论文50余篇." ]
  [ "王浩，男，1977年生. 2000年大学毕业于南开大学，2005年获南开大学获理学博士学位. 之后，在德国维尔茨堡大学作为洪堡研究员进行研究，2007年在美国加州大学洛杉矶分校医学院Crump分子成像研究所和加州纳米系统研究中心从事纳米技术在癌症诊断与治疗方面的研究. 2011年加入国家纳米科学中心中国科学院纳米生物效应与安全性重点实验室. 入选万人计划青年拔尖人才获得者，获国家杰出青年科学基金资助. 目前主要研究方向为医用高分子材料体. 提出了活体自组装的新理念，实现材料在病灶部位的靶向、富集和滞留. 在Nat. Commun.， Angew. Chem. Int. Ed.， JACS， Adv. Mater.， ACS Nano等期刊上发表论文100余篇." ]
- 基金信息：
  
  国家重点研发计划项目(基金号 2020YFA0210800)
- DOI：10.11777/j.issn.1000-3304.2024.24039
  中图分类号：
- 纸质出版日期：2024-05-20，
  
  网络出版日期：2024-03-27，
  
  收稿日期：2024-02-01，
  
  录用日期：2024-03-06
- 稿件说明：
移动端阅览
廖宇思, 梁剑箫, 温转, 蔡明泽, 宋张志, 张薿元, 安红维, 王浩. 生物医用高分子材料细胞膜表面功能化的策略与应用. 高分子学报, 2024, 55(5), 553-572

Liao, Y. S.; Liang, J. X.; Wen, Z.; Cai, M. Z.; Song, Z. Z.; Zhang, N. Y.; An, H. W.; Wang, H. Strategies and applications of cell membrane surface functionalization of polymer materials. Acta Polymerica Sinica, 2024, 55(5), 553-572
廖宇思, 梁剑箫, 温转, 蔡明泽, 宋张志, 张薿元, 安红维, 王浩. 生物医用高分子材料细胞膜表面功能化的策略与应用. 高分子学报, 2024, 55(5), 553-572 DOI： 10.11777/j.issn.1000-3304.2024.24039.

Liao, Y. S.; Liang, J. X.; Wen, Z.; Cai, M. Z.; Song, Z. Z.; Zhang, N. Y.; An, H. W.; Wang, H. Strategies and applications of cell membrane surface functionalization of polymer materials. Acta Polymerica Sinica, 2024, 55(5), 553-572 DOI： 10.11777/j.issn.1000-3304.2024.24039.

摘要

细胞膜是细胞的外层包裹结构，保护细胞内部免受外界干扰. 通过对细胞膜进行修饰，引入特定的分子或结构，可以实现对细胞命运和功能的调控，从而赋予细胞特殊的功能. 近年来，利用高分子材料在细胞膜上发生自组装的策略用于功能化修饰细胞膜表面已被广泛研究. 本文综述了利用高分子、多肽及DNA纳米材料对细胞膜进行修饰的策略，总结了其带来的包括受体寡聚化、细胞膜通透性改变以及调节细胞间通讯的生物效应以及细胞膜表面功能化的生物应用.

Abstract

The cell membrane

the outer protective structure of a cell

serves to shield its internal components from external disruptions. By manipulating the cell membrane and incorporating specific molecules or structures

one can exert control over the fate and functionality of cells

thereby imbuing them with specialized functions. In recent years

the strategy of using biomacromolecules to self-assemble on cell membranes has been widely studied for functionalizing the surface of cell membranes. This paper reviews that the self-assembly of different biomacromolecules on the cell membrane surface can change the biological effects of cells and produce positive effects in tumor immunotherapy. It is elaborated that when biomacromolecular materials are self-assembled on the cell membrane

it can cause biological effects of cells

such as oligomerization of cell membrane receptor proteins to activate immune cells

changing cell membrane permeability to promote endocytosis

etc.

At the same time

its application in tumor treatment is briefly introduced

and the future development of self-assembly technology modified cell membrane surface is prospected.

关键词

细胞膜组装高分子多肽肿瘤治疗

Keywords

Cell membraneSelf-assemblyPolymer materialsPeptideCancer treatment

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