Two kinds of substituted acetylene monomers were synthesized using propargylamine with Boc-L-alanine and acrylic acid.These two kinds of monomers were separately named as chiral monomers 1 and achiral monomers 2.Then chiral monomers 1 and achiral monomers 2 were polymerized using (nbd)Rh+[6-C6H5B-- (C6H5)3] as catalyst to obtain copolymers with Mn=2.0104

yield 60%.CD and UV-Vis spectroscopic data indicated the copolymers and homopolymers exhibited high optical activity and formed stable single helical conformation.And the achiral monomers did not affect the helical structure of the copolymers

but the optical activities and CD intensity of the copolymers were slightly lower than those of the homopolymers.The copolymer 2 was prepared in the condition of TFA/CH2Cl2

and then it was grafted to the chemical modified silica nanoparticles by the condensation reaction.The surface grafting density of the silica nanoparticles was 2.4 mol/m2

which was estimated from the thermo-gravimetric curve.Finally

the chiral fluorescent polymeric microspheres were prepared by the distillation-precipitation polymerization of N-vinylcarbazole.TEM and SEM were used to observe the surface morphology and particle size of polymeric microspheres.UV-Vis and fluorescence spectra showed the chiral fluorescent polymeric microspheres had certain fluorescence properties.They will play an important role in the field of drug delivery and biomarkers.