Polycaprolactone (PCL) polyols with different functionalities and molecular weights modified with phosphorylation or epoxidation were designed and synthesised

Based on the effective reaction of hydroxyl group of acidic phosphate ester (P-OH) and alicyclic epoxy (E)

adjusting the molar ratios of E/P-OH functional groups

without any additives(such as catalyst

initiator or solvent)that may have some potential risk of biological toxicity when being applied in real clinical situations

two types of cross-linked PCL phosphoester elastic materials were designed and prepared:PCL210P/PCL309E (being called 109 for short)

PCL309P/PCL309E (being called 99 for short)

The structures of polyhydric alcohol of PCL modified with phosphorylation or epoxidation and cross-linked PCL phosphoester elastomers were characterized by 1H-NMR

31P-NMR and FTIR.The test and analysis of compressive mechanical properties

water contact angle

the performance of degradation and cells cytotoxicity in vitro

indicated that the cross-linked PCL elastomers had good mechanical properties

biocompatibility and biodegradability.Besides this

the adjustment of mechanical properties and biodegradability of the cross-linked PCL phosphoester elastic materials can be achieved within a certain range by adjusting the E/P-OH molar ratios and functionalities of PCL monomers.