Polyurethane acrylate(PUA) based on polyether-ester have potential applications in tissue engineering

artificial scaffold

and other medical devices.Polyether ester diol triblock copolymers (PLLA-PEG-PLLA

PLEL) were synthesized by ring opening polymerization of L-lactide(L-LA) with the presence of polyethylene glycol (PEG).It is also used as soft segments for the preparation of polyurethane acrylate (PUA) oligomers containing PLEL-diol

diisocyanate (isophorone diisocyanate IPDI and hexamethylene diisocyanate HDI) and hydroxyethyl methacrylate (HEMA).PLEL-diols and PUA oligomers were characterized by 1H-NMR and GPC.The PUAs were fabricated under UV light

followed with structure and morphology analysis (DSC and DMA) and hydrophilic property characterization (contact angle and swelling).The results showed that increasing length of hydrophobic PLLA in PLEL-diols reduced PUA hydrophilicity

crosslink density and biodegradation rate.With the same soft segment

PUA made from hard segment of HDI-HEMA showed higher hydrophilicity and biodegradation rate than PUA based on IPDI-HEMA

because of a cyclic structure of IPDI reducing the interaction with water.The degradation experiment indicates that the PUA membranes degraded most rapidly in PBS/H2O2/CoCl2 solution

then slower in lipase solution

and lowest in pure PBS solution.The oxidative degradation rate of PUA materials depended on the content of PEG in the soft segment.The highest weight loss of 82.62% was recorded from the PLEL1000-HDI (the highest PED content in the PUA) degradation experiment in 13 weeks.