以多组分点击化学为基础的高分子合成——高分子合成的新机遇

陶磊; 赵原; 杨斌; 危岩; 吴海波

doi:10.11777/j.issn1000-3304.2016.16218

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以多组分点击化学为基础的高分子合成——高分子合成的新机遇

专论 | 更新时间：2021-03-19

- 以多组分点击化学为基础的高分子合成——高分子合成的新机遇
- Multicomponent Click Chemistry in Polymer Synthesis——New Opportunity for Polymer Chemistry
- 高分子学报 2016年第11期页码：1482-1494
- 作者机构：
  
  清华大学化学系生命有机磷化学及化学生物学教育部重点实验室北京 100084
- 作者简介：
  
  [ "陶磊,男,1976年4月生.2006年于英国华威大学(Warwick University)获得博士学位.2006-2008,2008-2010年分别于美国加州大学洛杉矶分校和澳大利亚新南威尔士大学从事博士后研究,2010年加入清华大学化学系,现为清华大学化学系副研究员.主要研究方向为多组分点击化学、多组分聚合体系、自愈性水凝胶的生物应用" ]
- 基金信息：
  
  国家自然科学基金(（基金号21574073）资助项目)
- DOI：10.11777/j.issn1000-3304.2016.16218
  中图分类号：
- 纸质出版日期：2016-11，
  
  收稿日期：2016-6-30，
  
  修回日期：2016-8-14，
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陶磊, 赵原, 杨斌, 危岩, 吴海波. 以多组分点击化学为基础的高分子合成——高分子合成的新机遇[J]. 高分子学报, 2016,(11):1482-1494.

Lei Tao, Yuan Zhao, Bin Yang, Yen Wei, Hai-bo Wu. Multicomponent Click Chemistry in Polymer Synthesis——New Opportunity for Polymer Chemistry[J]. Acta Polymerica Sinica, 2016,(11):1482-1494.
陶磊, 赵原, 杨斌, 危岩, 吴海波. 以多组分点击化学为基础的高分子合成——高分子合成的新机遇[J]. 高分子学报, 2016,(11):1482-1494. DOI： 10.11777/j.issn1000-3304.2016.16218.

Lei Tao, Yuan Zhao, Bin Yang, Yen Wei, Hai-bo Wu. Multicomponent Click Chemistry in Polymer Synthesis——New Opportunity for Polymer Chemistry[J]. Acta Polymerica Sinica, 2016,(11):1482-1494. DOI： 10.11777/j.issn1000-3304.2016.16218.

摘要

高分子合成是高分子学科的基础，合理选择有机反应制备新型聚合物是高分子合成方法学的重要研究内容.最近，利用多组分反应合成高分子引起了人们的广泛关注，成为高分子合成中充满活力的新领域.在研究多组分反应的过程中，人们发现了多组分反应与点击反应存在交集，并提出了多组分点击化学的概念，即某些高效、原子经济、环境友好的多组分反应也可视为点击反应.本文将系统介绍多组分点击反应的特点、以多组分点击反应为基础的聚合物合成方法、通过多组分点击反应得到的功能聚合物及其应用等，归纳总结这一新兴领域的初步结果，并对其未来发展提出一些拙见.

Abstract

Polymer synthesis is the starting point of polymer science

screening and using suitable organic reactions to prepare novel polymers is the core of polymer synthesis.Recently

polymer synthesis

via

multicomponent reactions (MCRs) has attracted widespread attention and is becoming a new vibrant branch of polymer chemistry.During the study of MCRs

the overlap between click chemistry and multicomponent reactions has been discovered

leading to the concept of multicomponent click (MCC) chemistry

i.e.

some highly efficient

atom economy multicomponent reactions

which only form harmless byproducts

can also be looked at as click reactions.The MCC reactions can work as efficient coupling tools like traditional two-component click reactions

meanwhile

new functional groups can be easily introduced due to the multicomponent nature of those reactions.As a result

multifunctional polymers

which are normally prepared

via

laborious multi-step methods

can be facilely achieved through one-step MCC reactions

providing a new strategy to synthesize functional polymers for multipurpose applications.In this article

the similar characteristics of click chemistry and MCRs will be discussed to illuminate the concept of MCC chemistry.As concrete examples

the large-scaled prepared functional polymers

via

the Biginelli reaction (a typical MCC reaction) will be introduced

suggesting the Biginelli reaction an excellent elementary reaction for polymer synthesis.The chain-end or chain-middle modified polymers

via

the Ugi reaction (another typical MCC reaction) will also be presented

indicating the Ugi reaction a powerful tool for the preparation of high value-added polymers.In particular

the advantage and disadvantage of the Biginelli reaction and the Ugi reaction will be pointed out

respectively

and some perspectives for the future development of multicomponent click chemistry in polymer chemistry will be summarized.

关键词

高分子合成多组分反应点击化学多组分点击化学

Keywords

Polymer synthesisMulticomponent reactionsClick chemistryMulticomponent click chemistry

references

H C Kolb , M Finn , K B Sharpless . Angew Chem Int Ed , 2001 . 40 ( 11 ): 2004 - 2021 . DOI:10.1002/(ISSN)1521-3773http://doi.org/10.1002/(ISSN)1521-3773.

R K Iha , K L Wooley , A M Nystrom , D J Burke , M J Kade , C J Hawker . Chem Rev , 2009 . 109 ( 11 ): 5620 - 5686 . DOI:10.1021/cr900138thttp://doi.org/10.1021/cr900138t.

C R Becer , R Hoogenboom , U S Schubert . Angew Chem Int Ed , 2009 . 48 ( 27 ): 4900 - 4908 . DOI:10.1002/anie.v48:27http://doi.org/10.1002/anie.v48:27.

J C Jewett , C R Bertozzi . Chem Soc Rev , 2010 . 39 ( 4 ): 1272 - 1279 . DOI:10.1039/b901970ghttp://doi.org/10.1039/b901970g.

E M Sletten , C R Bertozzi . Angew Chem Int Ed , 2009 . 48 ( 38 ): 6974 - 6998 . DOI:10.1002/anie.v48:38http://doi.org/10.1002/anie.v48:38.

J M Baskin , J A Prescher , S T Laughlin , N J Agard , P V Chang , I A Miller , A Lo , J A Codelli , C R Bertozzi . PNAS , 2007 . 104 ( 43 ): 16793 - 16797 . DOI:10.1073/pnas.0707090104http://doi.org/10.1073/pnas.0707090104.

P Espeel , F E Du Prez . Macromolecules , 2014 . 48 ( 1 ): 2 - 14.

P Wu , A K Feldman , A K Nugent , C J Hawker , A Scheel , B Voit , J Pyun , J M Fréchet , K B Sharpless , V V Fokin . Angew Chem Int Ed , 2004 . 43 ( 30 ): 3928 - 3932 . DOI:10.1002/(ISSN)1521-3773http://doi.org/10.1002/(ISSN)1521-3773.

K L Killops , L M Campos , C J Hawker . J Am Chem Soc , 2008 . 130 ( 15 ): 5062 - 5064 . DOI:10.1021/ja8006325http://doi.org/10.1021/ja8006325.

A Qin , J W Lam , B Z Tang . Chem Soc Rev , 2010 . 39 ( 7 ): 2522 - 2544 . DOI:10.1039/b909064ahttp://doi.org/10.1039/b909064a.

A Qin , J W Lam , B Z Tang . Macromolecules , 2010 .43 ( 21 ): 8693 - 8702 . DOI:10.1021/ma101064uhttp://doi.org/10.1021/ma101064u.

A Qin , J W Lam , B Z Tang . Prog Polym Sci , 2012 . 37 ( 1 ): 182 - 209 . DOI:10.1016/j.progpolymsci.2011.08.002http://doi.org/10.1016/j.progpolymsci.2011.08.002.

L Yang , X Liu , X Tan , H Yang , Z Wang , X Zhang . Polym Chem , 2014 . 5 ( 2 ): 323 - 326 . DOI:10.1039/C3PY01161Ehttp://doi.org/10.1039/C3PY01161E.

Q Song , F Li , L L Yang , Z Q Wang , X Zhang . Polym Chem , 2014 . 6 ( 3 ): 369 - 372.

Z Ge , Y Zhou , J Xu , H Liu , D Chen , S Liu . J Am Chem Soc , 2009 . 131 ( 5 ): 1628 - 1629 . DOI:10.1021/ja808772zhttp://doi.org/10.1021/ja808772z.

X Zhu , N Zhou , Z Zhang , B Sun , Y Yang , J Zhu , X Zhu . Angew Chem Int Ed , 2011 . 50 ( 29 ): 6615 - 6618 . DOI:10.1002/anie.v50.29http://doi.org/10.1002/anie.v50.29.

H Zhang , N Zhou , X Zhu , X Chen , Z Zhang , W Zhang , J Zhu , Z Hu , X Zhu . Macromol Rapid Commun , 2012 . 33 ( 21 ): 1845 - 1851 . DOI:10.1002/marc.v33.21http://doi.org/10.1002/marc.v33.21.

Y Q Dong , Y Y Tong , B T Dong , F S Du , Z C Li . Macromolecules , 2009 . 42 ( 8 ): 2940 - 2948 . DOI:10.1021/ma802361hhttp://doi.org/10.1021/ma802361h.

C F Hansell , P Espeel , M M Stamenovic , I A Barker , A P Dove , F E Du Prez , R K O'Reilly . J Am Chem Soc , 2011 . 133 ( 35 ): 13828 - 13831 . DOI:10.1021/ja203957hhttp://doi.org/10.1021/ja203957h.

K K Oehlenschlaeger , J O Mueller , N B Heine , M Glassner , N K Guimard , G Delaittre , F G Schmidt , C Barner-Kowollik . Angew Chem Int Ed , 2013 . 52 ( 2 ): 762 - 766 . DOI:10.1002/anie.201206905http://doi.org/10.1002/anie.201206905.

U Shah , Jr J O Lay , A Proctor . J Am Oil Chem Soc , 2013 . 90 ( 1 ): 155 - 158 . DOI:10.1007/s11746-012-2142-7http://doi.org/10.1007/s11746-012-2142-7.

S Billiet , K De Bruycker , F Driessen , H Goossens , V Van Speybroeck , J M Winne , F E Du Prez . Nat Chem , 2014 . 6 ( 9 ): 815 - 821 . DOI:10.1038/nchem.2023http://doi.org/10.1038/nchem.2023.

O Kreye , T Tóth , M A Meier . J Am Chem Soc , 2011 . 133 ( 6 ): 1790 - 1792 . DOI:10.1021/ja1113003http://doi.org/10.1021/ja1113003.

O Kreye , O Türünç , A Sehlinger , J Rackwitz , M A Meier . Chem Eur J , 2012 . 18 ( 18 ): 5767 - 5776 . DOI:10.1002/chem.v18.18http://doi.org/10.1002/chem.v18.18.

X X Deng , L Li , Z L Li , A Lv , F S Du , Z C Li . ACS Macro Lett , 2012 . 1 ( 11 ): 1300 - 1303 . DOI:10.1021/mz300456phttp://doi.org/10.1021/mz300456p.

L Li , A Lv , X X Deng , F S Du , Z C Li . Chem Commun , 2013 . 49 ( 76 ): 8549 - 8551 . DOI:10.1039/c3cc44557ghttp://doi.org/10.1039/c3cc44557g.

Y Z Wang , X X Deng , L Li , Z L Li , F S Du , Z C Li . Polym Chem , 2013 . 4 ( 3 ): 444 - 448 . DOI:10.1039/C2PY20927Fhttp://doi.org/10.1039/C2PY20927F.

X W Kan , X X Deng , F S Du , Z C Li . Macromol Chem Phys , 2014 . 215 ( 22 ): 2221 - 2228 . DOI:10.1002/macp.v215.22http://doi.org/10.1002/macp.v215.22.

C Y Chan , N W Tseng , J W Lam , J Liu , R T Kwok , B Z Tang . Macromolecules , 2013 . 46 ( 9 ): 3246 - 3256 . DOI:10.1021/ma4005346http://doi.org/10.1021/ma4005346.

Y Liu , M Gao , J W Lam , R Hu , B Z Tang . Macromolecules , 2014 . 47 ( 15 ): 4908 - 4919 . DOI:10.1021/ma501477whttp://doi.org/10.1021/ma501477w.

B Yang , Y Zhao , C Fu , C Zhu , Y Zhang , S Wang , Y Wei , L Tao . Polym Chem , 2014 . 5 ( 8 ): 2704 - 2708 . DOI:10.1039/c4py00001chttp://doi.org/10.1039/c4py00001c.

B Yang , Y Zhao , S Wang , Y Zhang , C Fu , Y Wei , L Tao . Macromolecules , 2014 . 47 ( 16 ): 5607 - 5612 . DOI:10.1021/ma501385mhttp://doi.org/10.1021/ma501385m.

C Zhu , B Yang , Y Zhao , C Fu , L Tao , Y Wei . Polym Chem , 2013 . 4 ( 21 ): 5395 - 5400 . DOI:10.1039/c3py00553dhttp://doi.org/10.1039/c3py00553d.

Y Zhang , Y Zhao , B Yang , C Zhu , Y Wei , L Tao . Polym Chem , 2014 . 5 ( 6 ): 1857 - 1862 . DOI:10.1039/C3PY01486Jhttp://doi.org/10.1039/C3PY01486J.

R Kakuchi , P Theato . ACS Macro Lett , 2014 . 3 ( 4 ): 329 - 332 . DOI:10.1021/mz500139chttp://doi.org/10.1021/mz500139c.

A Sehlinger , T Stalling , J Martens , M A Meier . Macromol Chem Phys , 2014 . 215 ( 5 ): 412 - 420 . DOI:10.1002/macp.v215.5http://doi.org/10.1002/macp.v215.5.

Q Zhang , Y Zhang , Y Zhao , B Yang , C Fu , Y Wei , L Tao . ACS Macro Lett , 2015 . 4 ( 1 ): 128 - 132 . DOI:10.1021/mz500734chttp://doi.org/10.1021/mz500734c.

Y Zhao , B Yang , C Zhu , Y Zhang , S Wang , C Fu , Y Wei , L Tao . Polym Chem , 2014 . 5 ( 8 ): 2695 - 2699 . DOI:10.1039/c4py00058ghttp://doi.org/10.1039/c4py00058g.

P Biginelli . Berichte der deutschen chemischen Gesellschaft , 1891 . 24 ( 1 ): 1317 - 1319 . DOI:10.1002/(ISSN)1099-0682http://doi.org/10.1002/(ISSN)1099-0682.

P Biginelli . Berichte der deutschen chemischen Gesellschaft , 1891 . 24 ( 2 ): 2962 - 2967 . DOI:10.1002/(ISSN)1099-0682http://doi.org/10.1002/(ISSN)1099-0682.

C O Kappe . Eur J Med Chem , 2000 . 35 ( 12 ): 1043 - 1052 . DOI:10.1016/S0223-5234(00)01189-2http://doi.org/10.1016/S0223-5234(00)01189-2.

G C Rovnyak , K S Atwal , A Hedberg , S D Kimball , S Moreland , J Z Gougoutas , B C O'Reilly , J Schwartz , M F Malley . J Med Chem , 1992 . 35 ( 17 ): 3254 - 3263 . DOI:10.1021/jm00095a023http://doi.org/10.1021/jm00095a023.

R Chikhale , R Bhole , P Khedekar , K Bhusari . Eur J Med Chem , 2009 . 44 ( 9 ): 3645 - 3653 . DOI:10.1016/j.ejmech.2009.02.021http://doi.org/10.1016/j.ejmech.2009.02.021.

G J Grover , S Dzwonczyk , D M McMullen , D E Normandin , C S Parham , P G Sleph , S Moreland . J Cardiovasc Pharmacol , 1995 . 26 ( 2 ): 289 - 294 . DOI:10.1097/00005344-199508000-00015http://doi.org/10.1097/00005344-199508000-00015.

D Russowsky , R F Canto , SA Sanches , M G D'Oca , A de Fatima , R A Pilli , L K Kohn , MA Antônio , J E de Carvalho . Bioorg Chem , 2006 . 34 ( 4 ): 173 - 182 . DOI:10.1016/j.bioorg.2006.04.003http://doi.org/10.1016/j.bioorg.2006.04.003.

B P Kumar , G Sankar , R N Baig , S Chandrashekaran . Eur.J Med Chem , 2009 . 44 ( 10 ): 4192 - 4198 . DOI:10.1016/j.ejmech.2009.05.014http://doi.org/10.1016/j.ejmech.2009.05.014.

K R Babu , V K Rao , Y N Kumar , K Polireddy , K V Subbaiah , M Bhaskar , V Lokanatha , C N Raju . Antivir Res , 2012 . 95 ( 2 ): 118 - 127 . DOI:10.1016/j.antiviral.2012.05.010http://doi.org/10.1016/j.antiviral.2012.05.010.

M Deshmukh , S Salunkhe , D Patil , P Anbhule . Eur J Med Chem , 2009 . 44 ( 6 ): 2651 - 2654 . DOI:10.1016/j.ejmech.2008.10.018http://doi.org/10.1016/j.ejmech.2008.10.018.

S Chitra , D Devanathan , K Pandiarajan . Eur J Med Chem , 2010 . 45 ( 1 ): 367 - 371 . DOI:10.1016/j.ejmech.2009.09.018http://doi.org/10.1016/j.ejmech.2009.09.018.

A K Bose , S Pednekar , S N Ganguly , G Chakraborty , M S Manhas . Tetrahedron Lett , 2004 . 45 ( 45 ): 8351 - 8353 . DOI:10.1016/j.tetlet.2004.09.064http://doi.org/10.1016/j.tetlet.2004.09.064.

P Espeel , F Goethals , F E Du Prez . J Am Chem Soc , 2011 . 133 ( 6 ): 1678 - 1681 . DOI:10.1021/ja1098098http://doi.org/10.1021/ja1098098.

C H Fujimoto , M A Hickner , C J Cornelius , D A Loy . Macromolecules , 2005 . 38 ( 12 ): 5010 - 5016 . DOI:10.1021/ma0482720http://doi.org/10.1021/ma0482720.

Y Zhao , Y Yu , Y Zhang , X Wang , B Yang , Y Zhang , Q Zhang , C Fu , Y Wei , L Tao . Polym Chem , 2015 . 6 ( 27 ): 4940 - 4945 . DOI:10.1039/C5PY00684Hhttp://doi.org/10.1039/C5PY00684H.

A C Boukis , A Llevot , M A Meier . Macromol Rapid Commun , 2016 . 37 ( 7 ): 643 - 649 . DOI:10.1002/marc.v37.7http://doi.org/10.1002/marc.v37.7.

M A Gauthier , M I Gibson , H A Klok . Angew Chem Int Ed , 2009 . 48 ( 1 ): 48 - 58 . DOI:10.1002/anie.200801951http://doi.org/10.1002/anie.200801951.

Y Zhao , H Wu , Y Zhang , X Wang , B Yang , Q Zhang , X Ren , C Fu , Y Wei , Z Wang . ACS Macro Lett , 2015 . 4 ( 8 ): 843 - 847 . DOI:10.1021/acsmacrolett.5b00428http://doi.org/10.1021/acsmacrolett.5b00428.

G Gody , C Rossner , J Moraes , P Vana , T Maschmeyer , S Perrier . J Am Chem Soc , 2012 . 134 ( 30 ): 12596 - 12603 . DOI:10.1021/ja3030643http://doi.org/10.1021/ja3030643.

S Wang , C Fu , Y Wei , L Tao . Macromol Chem Phys , 2014 . 215 ( 6 ): 486 - 492 . DOI:10.1002/macp.v215.6http://doi.org/10.1002/macp.v215.6.

L Tao , C Fu , Y Wei . Polym Int , 2015 . 64 ( 6 ): 705 - 712 . DOI:10.1002/pi.2015.64.issue-6http://doi.org/10.1002/pi.2015.64.issue-6.

S Wang , C Fu , Y Zhang , L Tao , S Li , Y Wei . ACS Macro Lett , 2012 . 1 ( 10 ): 1224 - 1227 . DOI:10.1021/mz300444whttp://doi.org/10.1021/mz300444w.

C Fu , B Yang , C Zhu , S Wang , Y Zhang , Y Wei , L Tao . Polym Chem , 2013 . 4 ( 24 ): 5720 - 5725 . DOI:10.1039/c3py00841jhttp://doi.org/10.1039/c3py00841j.

Y Zhang , C Fu , C Zhu , S Wang , L Tao , Y Wei . Polym Chem , 2013 . 4 ( 3 ): 466 - 469 . DOI:10.1039/C2PY21039Hhttp://doi.org/10.1039/C2PY21039H.

J Geng , J Lindqvist , G Mantovani , D M Haddleton . Angew Chem Int Ed , 2008 . 47 ( 22 ): 4180 - 4183 . DOI:10.1002/(ISSN)1521-3773http://doi.org/10.1002/(ISSN)1521-3773.

H Wu , C Fu , Y Zhao , B Yang , Y Wei , Z Wang , L Tao . ACS Macro Lett , 2015 . 4 ( 11 ): 1189 - 1193 . DOI:10.1021/acsmacrolett.5b00637http://doi.org/10.1021/acsmacrolett.5b00637.

X Ren , B Yang , Y Zhao , X Zhang , X Wang , Y Wei , L Tao . Polymer , 2015 . 64 210 - 215 . DOI:10.1016/j.polymer.2015.02.033http://doi.org/10.1016/j.polymer.2015.02.033.

A Dömling , I Ugi . Angew Chem Int Ed , 2000 . 39 ( 18 ): 3168 - 3210 . DOI:10.1002/(ISSN)1521-3773http://doi.org/10.1002/(ISSN)1521-3773.

A Dömling . Chem Rev , 2006 . 106 ( 1 ): 17 - 89 . DOI:10.1021/cr0505728http://doi.org/10.1021/cr0505728.

I Ugi , R Meyr , U Fetzer , C Steinbruckner . Angew Chem , 1959 . 71 386 .

I Ugi , C Steinbrückner . Angew Chem , 1960 . 72 ( 7-8 ): 267 - 268 . DOI:10.1002/(ISSN)1521-3757http://doi.org/10.1002/(ISSN)1521-3757.

A E de Nooy , G Masci , V Crescenzi . Macromolecules , 1999 . 32 ( 4 ): 1318 - 1320 . DOI:10.1021/ma9815455http://doi.org/10.1021/ma9815455.

CV Robotham , C Baker , B Cuevas , K Abboud , DL Wright . Mol Divers , 2003 . 6 ( 3-4 ): 237 - 244.

A Sehlinger , P K Dannecker , O Kreye , M A Meier . Macromolecules , 2014 . 47 ( 9 ): 2774 - 2783 . DOI:10.1021/ma500504whttp://doi.org/10.1021/ma500504w.

Y He , W He , D Liu , T Gu , R Wei , X Wang . Polym Chem , 2013 . 4 ( 2 ): 402 - 406 . DOI:10.1039/C2PY20653Fhttp://doi.org/10.1039/C2PY20653F.

J Wang , Y Zhou , X Wang , Y He . RSC Adv , 2015 . 5 ( 13 ): 9476 - 9481 . DOI:10.1039/C4RA14926Bhttp://doi.org/10.1039/C4RA14926B.

A J Inglis , S Sinnwell , M H Stenzel , C Barner-Kowollik . Angew Chem Int Ed , 2009 . 48 ( 13 ): 2411 - 2414 . DOI:10.1002/anie.200805993http://doi.org/10.1002/anie.200805993.

J A Opsteen , J C van Hest . Chem Commun , 2005 . 1 57 - 59.

R Langer , J Folkman . Nature , 1976 . 263 797 - 800 . DOI:10.1038/263797a0http://doi.org/10.1038/263797a0.

A Abuchowski , J R McCoy , N C Palczuk , T van Es , F F Davis . J Biol Chem , 1977 . 252 ( 11 ): 3582 - 3586.

F M Veronese , G Pasut . Drug Discov Today , 2005 . 10 ( 21 ): 1451 - 1458 . DOI:10.1016/S1359-6446(05)03575-0http://doi.org/10.1016/S1359-6446(05)03575-0.

H Wu , B Yang , Y Zhao , Y Wei , Z Wang . Polym Chem , 2016 . 7 ( 30 ): 4867 - 4872 . DOI:10.1039/C6PY00781Chttp://doi.org/10.1039/C6PY00781C.

B Yang , Y Zhao , X Ren , X Zhang , C Fu , Y Zhang , Y Wei , L Tao . Polym Chem , 2015 . 6 ( 4 ): 509 - 513 . DOI:10.1039/C4PY01323Ahttp://doi.org/10.1039/C4PY01323A.

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