刺激响应型多肽的研究及其在肿瘤诊疗中的应用

邱文秀; 程翰; 张先正; 卓仁禧

doi:10.11777/j.issn1000-3304.2018.17256

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刺激响应型多肽的研究及其在肿瘤诊疗中的应用

综述 | 更新时间：2021-01-26

- 刺激响应型多肽的研究及其在肿瘤诊疗中的应用
- Studies on Stimulus Responsive Peptides and Their Applications in Tumor Diagnosis and Treatment
- 高分子学报 2018年第1期页码：32-44
- 作者机构：
  
  武汉大学化学与分子科学学院生物医用高分子材料教育部重点实验室武汉 430072
- 作者简介：
  
  张先正, E-mail: xz-zhang@whu.edu.cnXian-zheng Zhang, E-mail: xz-zhang@whu.edu.cn
- 基金信息：
  
  国家自然科学基金(51573142);国家自然科学基金(21474077)
- DOI：10.11777/j.issn1000-3304.2018.17256
  中图分类号：
- 纸质出版日期：2018-1-20，
  
  收稿日期：2017-9-4，
  
  修回日期：2017-9-15，
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邱文秀, 程翰, 张先正, 卓仁禧. 刺激响应型多肽的研究及其在肿瘤诊疗中的应用[J]. 高分子学报, 2018,(1):32-44.

Qiu Wen-xiu, Cheng Han, Zhang Xian-zheng, Zhuo Ren-xi. Studies on Stimulus Responsive Peptides and Their Applications in Tumor Diagnosis and Treatment[J]. Acta Polymerica Sinica, 2018,(1):32-44.
邱文秀, 程翰, 张先正, 卓仁禧. 刺激响应型多肽的研究及其在肿瘤诊疗中的应用[J]. 高分子学报, 2018,(1):32-44. DOI： 10.11777/j.issn1000-3304.2018.17256.

Qiu Wen-xiu, Cheng Han, Zhang Xian-zheng, Zhuo Ren-xi. Studies on Stimulus Responsive Peptides and Their Applications in Tumor Diagnosis and Treatment[J]. Acta Polymerica Sinica, 2018,(1):32-44. DOI： 10.11777/j.issn1000-3304.2018.17256.

摘要

多肽因其独特的理化性能，如生物相容性好，合成修饰方法简单易行，功能多样化和生物体内响应性高等优点，已被广泛用于构建刺激响应型肿瘤诊疗体系.这种以刺激响应型多肽为基础构建的药物诊疗体系，能够在到达肿瘤以前保持药物的零释放，而在靶向到达肿瘤组织后，在肿瘤组织特殊微环境或是外源刺激下（如肿瘤特异性表达酶的刺激、pH刺激和氧化还原刺激等），实现药物的精准靶向释放同时释放出各种诊疗信号.这种具有特异性刺激响应型的多肽载体可以最大程度的提高药物的抗肿瘤效果，降低药物的毒副作用，以及提高肿瘤诊断的精准度.本文简要综述了近年来不同刺激响应型多肽在肿瘤诊疗领域的研究进展.

Abstract

Tumor is a most deadly killer of humans. The low therapeutic efficiency and significant side effects caused by antitumor drugs are the main problems for tumor treatment currently. The use of tumor targeting drug carrier can greatly improve the therapeutic effect and reduce the side effects of antitumor drugs. However

the complex microenvironment of tumor (such as tumor progression

the expression level of related enzymes

and precise location of tumor cells) and individual difference among cancer patients (like drug intake efficiency and drug tolerance) often lead to failure of standardized treatment modality. Therefore

to get a good knowledge of the multifarious microenvironment of tumor is important for realizing precise and personalized treatment. In order to meet these requirements

it is urgent to develop multifunctional drug carriers for tumor targeting

diagnosis

imaging

treatment and prognosis. Many kinds of strategies have been performed to meet the multifunctionality requirement of the drug carriers

such as nanotechnology

stimuli-responsive technology and so on. At the same time

many kinds of materials were developed

like organic polymer

inorganic luminescent platform

functional peptide. Among them

peptide has drawn much attention. As we know

peptide has been widely used in the construction of stimulus responsive drug delivery system because of its unique properties such as good biocompatibility

simple synthesis

versatility

high responsiveness in the organism and so on. Ideally

through the enhanced permeability and retention (EPR) effect or the active tumor targeting process

the drug delivery system with functional peptide could reach the tumor

and then the loaded drugs and varies of diagnosis signal were released under special stimulus of tumor microenvironment or exogenous stimulus. This specific stimulating response of the peptide based carrier can maximize the anticancer effect

reduce the side effects of anticancer drug and improve the accuracy of tumor diagnosis. This work briefly reviews the research progress in applications of different types of stimulus responsive peptides in tumor diagnosis and the treatment.

关键词

多肽刺激响应肿瘤诊疗药物传递

Keywords

PeptideStimulus responsiveTheranosticsDrug delivery

references

R Cheng , F Meng , C Deng , H A Klok , Z Zhong . . Biomaterials , 2013 . 34 ( 14 ): 3647 - 3657 . DOI:10.1016/j.biomaterials.2013.01.084http://doi.org/10.1016/j.biomaterials.2013.01.084.

J L Vivero-Escoto , I I Slowing , C W Wu , V S Y Lin . . J Am Chem Soc , 2009 . 131 ( 10 ): 3462 - 3463 . DOI:10.1021/ja900025fhttp://doi.org/10.1021/ja900025f.

Y Li , W Xiao , K Xiao , L Berti , J Luo , H P Tseng , G Fung , K S Lam . . Angew Chem Int Ed , 2012 . 124 ( 12 ): 2918 - 2923 . DOI:10.1002/ange.201107144http://doi.org/10.1002/ange.201107144.

L Palanikumar , E S Choi , J Y Cheon , S H Joo , J H Ryu . . Adv Funct Mater , 2015 . 25 ( 6 ): 957 - 965 . DOI:10.1002/adfm.201402755http://doi.org/10.1002/adfm.201402755.

J Liu , Z Luo , J Zhang , T Luo , J Zhou , X Zhao , K Cai . . Biomaterials , 2016 . 83 51 - 65 . DOI:10.1016/j.biomaterials.2016.01.008http://doi.org/10.1016/j.biomaterials.2016.01.008.

S Yu , J Ding , C He , Y Cao , W Xu , X Chen . . Adv Healthc Mater , 2014 . 3 ( 5 ): 752 - 760 . DOI:10.1002/adhm.201300308http://doi.org/10.1002/adhm.201300308.

S Ganta , H Devalapally , A Shahiwala , M Amiji . . J Control Release , 2008 . 126 ( 3 ): 187 - 204 . DOI:10.1016/j.jconrel.2007.12.017http://doi.org/10.1016/j.jconrel.2007.12.017.

P Yang , D Li , S Jin , J Ding , J Guo , W Shi , C Wang . . Biomaterials , 2014 . 35 ( 6 ): 2079 - 2088 . DOI:10.1016/j.biomaterials.2013.11.057http://doi.org/10.1016/j.biomaterials.2013.11.057.

Y B Khotskaya , G B Mills , K R M Shaw . . Annu Rev Med , 2017 . 68 ( 1 ): 113 - 125 . DOI:10.1146/annurev-med-102115-021556http://doi.org/10.1146/annurev-med-102115-021556.

J Rodon , J C Soria , R Berger , G Batist , A Tsimberidou , C Bresson , J J Lee , E Rubin , A Onn , R L Schilsky , W H Miller , A M Eggermont , J Mendelsohn , V Lazar , R Kurzrock . . Ann Oncol , 2015 . 26 ( 8 ): 1791 - 1798 . DOI:10.1093/annonc/mdv191http://doi.org/10.1093/annonc/mdv191.

M J Duffy , J Crown . . Clin Chem , 2008 . 54 ( 11 ): 1770 - 1779 . DOI:10.1373/clinchem.2008.110056http://doi.org/10.1373/clinchem.2008.110056.

D Gonzalez de Castro , P A Clarke , B Al-Lazikani , P Workman . . Clin Pharmacol Ther , 2013 . 93 ( 3 ): 252 - 259 . DOI:10.1038/clpt.2012.237http://doi.org/10.1038/clpt.2012.237.

R Simon , S Roychowdhury . . Nat Rev Drug Discov , 2013 . 12 ( 5 ): 358 - 369 . DOI:10.1038/nrd3979http://doi.org/10.1038/nrd3979.

E Ruoslahti . . Adv Mater , 2012 . 24 ( 28 ): 3747 - 3756 . DOI:10.1002/adma.v24.28http://doi.org/10.1002/adma.v24.28.

T R Pearce , K Shroff , E Kokkoli . . Adv Mater , 2012 . 24 ( 28 ): 3803 - 22, 3710 . DOI:10.1002/adma.v24.28http://doi.org/10.1002/adma.v24.28.

A Sergeeva , M G Kolonin , J J Molldrem , R Pasqualini , W Arap . . Adv Drug Deliv Rev , 2006 . 58 ( 15 ): 1622 - 1654 . DOI:10.1016/j.addr.2006.09.018http://doi.org/10.1016/j.addr.2006.09.018.

L Kong , C S Alves , W Hou , J Qiu , H Möhwald , H Tomás , X Shi . . ACS Appl Mater Interfaces , 2015 . 7 ( 8 ): 4833 - 4843 . DOI:10.1021/am508760whttp://doi.org/10.1021/am508760w.

Y T Ko , C Falcao , V P Torchilin . . Mol Pharm , 2009 . 6 ( 3 ): 971 - 977 . DOI:10.1021/mp900006hhttp://doi.org/10.1021/mp900006h.

Y Chen , G Liang . . Theranostics , 2012 . 2 ( 2 ): 139 DOI:10.7150/thno.3696http://doi.org/10.7150/thno.3696.

M Fan , D Yang , X Liang , J Ao , Z Li , H Wang , B Shi . . Biomed Pharmacother , 2015 . 70 268 - 273 . DOI:10.1016/j.biopha.2015.01.027http://doi.org/10.1016/j.biopha.2015.01.027.

M Black , A Trent , Y Kostenko , J S Lee , C Olive , M Tirrell . . Adv Mater , 2012 . 24 ( 28 ): 3845 - 3849 . DOI:10.1002/adma.v24.28http://doi.org/10.1002/adma.v24.28.

J Chen , R R Pompano , F W Santiago , L Maillat , R Sciammas , T Sun , H Han , D J Topham , A S Chong , J H Collier . . Biomaterials , 2013 . 34 ( 34 ): 8776 - 8785 . DOI:10.1016/j.biomaterials.2013.07.063http://doi.org/10.1016/j.biomaterials.2013.07.063.

A Accardo , M Vitiello , D Tesauro , M Galdiero , E Finamore , F Martora , R Mansi , P Ringhieri , G Morelli . . Int J Nanomed , 2014 . 9 2137 http://pubmedcentralcanada.ca/pmcc/articles/PMC4019629/.

K Y Choi , M Swierczewska , S Lee , X Chen . . Theranostics , 2012 . 2 ( 2 ): 156 DOI:10.7150/thno.4068http://doi.org/10.7150/thno.4068.

S R MacEwan , D J Callahan , A Chilkoti . . Nanomedicine , 2010 . 5 ( 5 ): 793 - 806 . DOI:10.2217/nnm.10.50http://doi.org/10.2217/nnm.10.50.

Z Amoozgar , Y Yeo . . Wiley Interdiscip Rev Nanomed Nanobiotechnol , 2012 . 4 ( 2 ): 219 - 233 . DOI:10.1002/wnan.v4.2http://doi.org/10.1002/wnan.v4.2.

M P Lutolf , J A Hubbell . . Nat Biotechnol , 2005 . 23 ( 1 ): 47 DOI:10.1038/nbt1055http://doi.org/10.1038/nbt1055.

L Zhu , P Kate , V P Torchilin . . ACS Nano , 2012 . 6 ( 4 ): 3491 - 3498 . DOI:10.1021/nn300524fhttp://doi.org/10.1021/nn300524f.

T W Liu , J Chen , L Burgess , B C Wilson , G Zheng , L Zhan , W K Liu , B Y Ha . . J Phys Chem B , 2014 . 119 ( 1 ): 44 - 53 . http://www.ncbi.nlm.nih.gov/pubmed/25474619.

L Zhu , P Kate , V P Torchilin . . ACS Nano , 2012 . 6 ( 4 ): 3491 - 3498 . DOI:10.1021/nn300524fhttp://doi.org/10.1021/nn300524f.

N Q Shi , W Gao , B Xiang , X R Qi . . Int J Nanomed , 2012 . 7 1613 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356196/.

H Xia , G Gu , Q Hu , Z Liu , M Jiang , T Kang , D Miao , Q Song , L Yao , Y Tu , H Chen , X Gao , J Chen . . Bioconjugate Chem , 2013 . 24 ( 3 ): 419 - 430 . DOI:10.1021/bc300520thttp://doi.org/10.1021/bc300520t.

W Gao , B Xiang , T T Meng , F Liu , X R Qi . . Biomaterials , 2013 . 34 ( 16 ): 4137 - 4149 . DOI:10.1016/j.biomaterials.2013.02.014http://doi.org/10.1016/j.biomaterials.2013.02.014.

S Y Li , H Cheng , W X Qiu , L H Liu , S Chen , Y Hu , B R Xie , B Li , X Z Zhang . . ACS Appl Mater Interfaces , 2015 . 7 ( 51 ): 28319 - 28329 . DOI:10.1021/acsami.5b08637http://doi.org/10.1021/acsami.5b08637.

S Huang , K Shao , Y Kuang , Y Liu , J Li , S An , Y Guo , H Ma , X He , C Jiang . . Biomaterials , 2013 . 34 ( 21 ): 5294 - 5302 . DOI:10.1016/j.biomaterials.2013.03.043http://doi.org/10.1016/j.biomaterials.2013.03.043.

K Han , Q Lei , H Z Jia , S B Wang , W N Yin , W H Chen , S X Cheng , X Z Zhang . . Adv Funct Mater , 2015 . 25 ( 8 ): 1248 - 1257 . DOI:10.1002/adfm.v25.8http://doi.org/10.1002/adfm.v25.8.

T A Aguilera , E S Olson , M M Timmers , T Jiang , R Y Tsien . . Integr Biol , 2009 . 1 ( 5-6 ): 371 - 381 . DOI:10.1039/b904878bhttp://doi.org/10.1039/b904878b.

T Jiang , E S Olson , Q T Nguyen , M Roy , P A Jennings , R Y Tsien . . Proc Natl Acad Sci USA , 2004 . 101 ( 51 ): 17867 - 17872 . DOI:10.1073/pnas.0408191101http://doi.org/10.1073/pnas.0408191101.

E N Savariar , C N Felsen , N Nashi , T Jiang , L G Ellies , P Steinbach , R Y Tsien , Q T Nguyen . . Cancer Res , 2013 . 73 ( 2 ): 855 - 864 . DOI:10.1158/0008-5472.CAN-12-2969http://doi.org/10.1158/0008-5472.CAN-12-2969.

E S Olson , T Jiang , T A Aguilera , Q T Nguyen , L G Ellies , M Scadeng , R Y Tsien . . Proc Natl Acad Sci USA , 2010 . 107 ( 9 ): 4311 - 4316 . DOI:10.1073/pnas.0910283107http://doi.org/10.1073/pnas.0910283107.

S Huang , K Shao , Y Liu , Y Kuang , J Li , S An , Y Guo , H Ma , C Jang . . ACS Nano , 2013 . 7 ( 3 ): 2860 - 2871 . DOI:10.1021/nn400548ghttp://doi.org/10.1021/nn400548g.

S Lee , E J Cha , K Park , S Y Lee , J K Hong , I C Sun , S Y Kim , K Choi , I C Kwon , K Kim , C H Ahn . . Angew Chem , 2008 . 120 ( 15 ): 2846 - 2849 . DOI:10.1002/(ISSN)1521-3757http://doi.org/10.1002/(ISSN)1521-3757.

D K Yi , I C Sun , J H Ryu , H Koo , C W Park , I C Youn , K Choi , I C Kwon , K Kim , C H Ahn . . Bioconjugate Chem , 2010 . 21 ( 12 ): 2173 - 2177 . DOI:10.1021/bc100308phttp://doi.org/10.1021/bc100308p.

B Jang , Y Choi . . Theranostics , 2012 . 2 ( 2 ): 190 DOI:10.7150/thno.3478http://doi.org/10.7150/thno.3478.

W X Qiu , L H Liu , S Y Li , Q Lei , G F Luo , X Z Zhang . . Small , 2017 . 13 ( 18 ): 1603956 DOI:10.1002/smll.v13.18http://doi.org/10.1002/smll.v13.18.

K Han , S B Wang , Q Lei , J Y Zhu , X Z Zhang . . ACS Nano , 2015 . 9 ( 10 ): 10268 - 10277 . DOI:10.1021/acsnano.5b04243http://doi.org/10.1021/acsnano.5b04243.

W H Chen , X D Xu , H Z Jia , Q Lei , G F Luo , S X Cheng , R X Zhuo , X Z Zhang . . Biomaterials , 2013 . 34 ( 34 ): 8798 - 8807 . DOI:10.1016/j.biomaterials.2013.07.084http://doi.org/10.1016/j.biomaterials.2013.07.084.

K Han , J Y Zhu , S B Wang , Z H Li , S X Cheng , X Z Zhang . . J Mater Chem B , 2015 . 3 ( 41 ): 8065 - 8069 . DOI:10.1039/C5TB01659Bhttp://doi.org/10.1039/C5TB01659B.

A J Barrett , H Kirschke . . Method Enzymol , 1981 . 80 535 - 561 . DOI:10.1016/S0076-6879(81)80043-2http://doi.org/10.1016/S0076-6879(81)80043-2.

M Kovář , J Strohalm , T Etrych , K Ulbrich , B Říhová . . Bioconjugate Chem , 2002 . 13 ( 2 ): 206 - 215 . DOI:10.1021/bc010063mhttp://doi.org/10.1021/bc010063m.

J Mai , D M Waisman , B F Sloane . . BBA-Protein Struct M , 2000 . 1477 ( 1 ): 215 - 230.

G Y Lee , W P Qian , L Wang , Y A Wang , C A Staley , M Satpathy , S Nie , H Mao , L Yang . . ACS Nano , 2013 . 7 ( 3 ): 2078 - 2089 . DOI:10.1021/nn3043463http://doi.org/10.1021/nn3043463.

J Tian , L Ding , Q Wang , Y Hu , L Jia , J S Yu , H Ju . . Anal Chem , 2015 . 87 ( 7 ): 3841 - 3848 . DOI:10.1021/acs.analchem.5b00429http://doi.org/10.1021/acs.analchem.5b00429.

J H Ryu , J H Na , H K Ko , D G You , S Park , E Jun , H J Yeom , D H Seo , J H Park , S Y Jeong , I S Kim , B S Kim , I C Kwon , K Choi , K Kim . . Biomaterials , 2014 . 35 ( 7 ): 2302 - 2311 . DOI:10.1016/j.biomaterials.2013.11.080http://doi.org/10.1016/j.biomaterials.2013.11.080.

Y Yuan , C J Zhang , M Gao , R Zhang , B Z Tang , B Liu . . Angew Chem , 2015 . 54 ( 6 ): 1780 - 1786 . DOI:10.1002/anie.201408476http://doi.org/10.1002/anie.201408476.

J Y Yhee , S A Kim , H Koo , S Son , J H Ryu , I C Youn , K Choi , I C Kwon , K Kim . . Theranostics , 2012 . 2 ( 2 ): 179 - 189 . DOI:10.7150/thno.3716http://doi.org/10.7150/thno.3716.

L L Lock , A G Cheetham , P Zhang , H Cui . . ACS Nano , 2013 . 7 ( 6 ): 4924 - 4932 . DOI:10.1021/nn400218ahttp://doi.org/10.1021/nn400218a.

R Zhang , J Yang , M Sima , Y Zhou , J Kopecek . . Proc Natl Acad Sci USA , 2014 . 111 ( 33 ): 12181 - 12186 . DOI:10.1073/pnas.1406233111http://doi.org/10.1073/pnas.1406233111.

H B Kern , S Srinivasan , A J Convertine , D Hockenbery , O W Press , P S Stayton . . Mol Pharm , 2017 . 14 ( 5 ): 1450 - 1459 . DOI:10.1021/acs.molpharmaceut.6b01178http://doi.org/10.1021/acs.molpharmaceut.6b01178.

I Das , A Krzyzosiak , K Schneider , L Wrabetz , M D'Antonio , N Barry , A Sigurdardottir , A Bertolotti . . Science , 2015 . 348 ( 6231 ): 239 - 242 . DOI:10.1126/science.aaa4484http://doi.org/10.1126/science.aaa4484.

B D Hopkins , B Fine , N Steinbach , M Dendy , Z Rapp , J Shaw , K Pappas , J S Yu , C Hodakoski , S Mense , J Klein , S Pegno , M L Sulis , H Goldstein , B Amendolara , L Lei , M Maurer , J Bruce , P Canoll , H Hibshoosh , R Parsons . . Science , 2013 . 341 ( 6144 ): 399 - 402 . DOI:10.1126/science.1234907http://doi.org/10.1126/science.1234907.

Z Zheng , H Sun , C Hu , G Li , X Liu , P Chen , Y Cui , J Liu , J Wang , G Liang . . Anal Chem , 2016 . 88 ( 6 ): 3363 - 3368 . DOI:10.1021/acs.analchem.6b00036http://doi.org/10.1021/acs.analchem.6b00036.

Y Yuan , L Wang , W Du , Z Ding , J Zhang , T Han , L An , H Zhang , G Liang . . Angew Chem , 2015 . 54 ( 33 ): 9700 - 9704 . DOI:10.1002/anie.v54.33http://doi.org/10.1002/anie.v54.33.

Z Zheng , A Tang , Y Guan , L Chen , F Wang , P Chen , W Wang , Y Luo , Y Tian , G Liang . . Anal Chem , 2016 . 88 ( 24 ): 11982 - 11985 . DOI:10.1021/acs.analchem.6b04139http://doi.org/10.1021/acs.analchem.6b04139.

Z Zheng , J Wang , P Chen , M Xie , L Zhang , Y Hou , X Zhang , J Jiang , J Wang , Q Lu , G Liang . . Nanoscale , 2016 . 8 ( 33 ): 15142 - 15146 . DOI:10.1039/C6NR03056Dhttp://doi.org/10.1039/C6NR03056D.

Z Hai , J Li , J Wu , J Xu , G Liang . . J Am Chem Soc , 2017 . 139 ( 3 ): 1041 - 1044 . DOI:10.1021/jacs.6b11041http://doi.org/10.1021/jacs.6b11041.

Z Zheng , P Chen , M Xie , C Wu , Y Luo , W Wang , J Jiang , G Liang . . J Am Chem Soc , 2016 . 138 ( 35 ): 11128 - 11131 . DOI:10.1021/jacs.6b06903http://doi.org/10.1021/jacs.6b06903.

L Dong , J Qian , Z Hai , J Xu , W Du , K Zhong , G Liang . . Anal Chem , 2017 . 89 ( 13 ): 6922 - 6925 . DOI:10.1021/acs.analchem.7b00621http://doi.org/10.1021/acs.analchem.7b00621.

K Han , Y Liu , W N Yin , S B Wang , Q Xu , R X Zhuo , X Z Zhang . . Adv Healthc Mater , 2014 . 3 ( 11 ): 1765 - 1768 . DOI:10.1002/adhm.v3.11http://doi.org/10.1002/adhm.v3.11.

L Zhang , J Lei , J Liu , F Ma , H Ju . . Chem Sci , 2015 . 6 ( 6 ): 3365 - 3372 . DOI:10.1039/C5SC00471Chttp://doi.org/10.1039/C5SC00471C.

A Han , H Wang , R T Kwok , S Ji , J Li , D Kong , B Z Tang , B Liu , Z Yang , D Ding . . Anal Chem , 2016 . 88 ( 7 ): 3872 - 3878 . DOI:10.1021/acs.analchem.6b00023http://doi.org/10.1021/acs.analchem.6b00023.

Y Yuan , Z Ding , J Qian , J Zhang , J Xu , X Dong , T Han , S Ge , Y Luo , Y Wang , K Zhong , G Liang . . Nano Lett , 2016 . 16 ( 4 ): 2686 - 2691 . DOI:10.1021/acs.nanolett.6b00331http://doi.org/10.1021/acs.nanolett.6b00331.

Y Yuan , C J Zhang , R T K Kwok , D Mao , B Z Tang , B Liu . . Chem Sci , 2017 . 8 ( 4 ): 2723 - 2728 . DOI:10.1039/C6SC04322Dhttp://doi.org/10.1039/C6SC04322D.

E M Barnett , X Zhang , D Maxwell , Q Chang , Worms D Piwnica . . Proc Natl Acad Sci USA , 2009 . 106 ( 23 ): 9391 - 9396 . DOI:10.1073/pnas.0812884106http://doi.org/10.1073/pnas.0812884106.

Y Yuan , R T Kwok , B Z Tang , B Liu . . J Am Chem Soc , 2014 . 136 ( 6 ): 2546 - 2554 . DOI:10.1021/ja411811whttp://doi.org/10.1021/ja411811w.

S Y Li , L H Liu , L Rong , W X Qiu , H Z Jia , B Li , F Li , X Z Zhang . . Adv Funct Mater , 2015 . 25 ( 47 ): 7317 - 7326 . DOI:10.1002/adfm.v25.47http://doi.org/10.1002/adfm.v25.47.

H J Li , J Z Du , J Liu , X J Du , S Shen , Y H Zhu , X Wang , X Ye , S Nie , J Wang . . ACS Nano , 2016 . 10 ( 7 ): 6753 - 6761 . DOI:10.1021/acsnano.6b02326http://doi.org/10.1021/acsnano.6b02326.

Y Ding , D Sun , G L Wang , H G Yang , H F Xu , J H Chen , Y Xie , Z Q Wang . . Int J Nanomed , 2015 . 10 6199 - 6214.

Y Zhao , W Ren , T Zhong , S Zhang , D Huang , Y Guo , X Yao , C Wang , W Q Zhang , X Zhang , Q Zhang . . J Control Release , 2016 . 222 56 - 66 . DOI:10.1016/j.jconrel.2015.12.006http://doi.org/10.1016/j.jconrel.2015.12.006.

S S Han , Z Y Li , J Y Zhu , K Han , Z Y Zeng , W Hong , W X Li , H Z Jia , Y Liu , R X Zhuo , X Z Zhang . . Small , 2015 . 11 ( 21 ): 2543 - 2554 . DOI:10.1002/smll.v11.21http://doi.org/10.1002/smll.v11.21.

K Han , W Y Zhang , J Zhang , Q Lei , S B Wang , J W Liu , X Z Zhang , H Y Han . . Adv Funct Mater , 2016 . 26 ( 24 ): 4351 - 4361 . DOI:10.1002/adfm.v26.24http://doi.org/10.1002/adfm.v26.24.

S Y Li , L H Liu , H Z Jia , W X Qiu , L Rong , H Cheng , X Z Zhang . . Chem Commun (Camb) , 2014 . 50 ( 80 ): 11852 - 11855 . DOI:10.1039/C4CC05008Hhttp://doi.org/10.1039/C4CC05008H.

M Altman , P Lee , A Rich , S Zhang . . Protein Sci , 2000 . 9 ( 6 ): 1095 - 1105 . DOI:10.1110/(ISSN)1469-896Xhttp://doi.org/10.1110/(ISSN)1469-896X.

O A Andreev , A D Dupuy , M Segala , S Sandugu , D A Serra , C O Chichester , D M Engelman , Y K Reshetnyak . . Proc Natl Acad Sci USA , 2007 . 104 ( 19 ): 7893 - 7898 . DOI:10.1073/pnas.0702439104http://doi.org/10.1073/pnas.0702439104.

O A Andreev , A G Karabadzhak , D Weerakkody , G O Andreev , D M Engelman , Y K Reshetnyak . . Proc Natl Acad Sci USA , 2010 . 107 ( 9 ): 4081 - 4086 . DOI:10.1073/pnas.0914330107http://doi.org/10.1073/pnas.0914330107.

Y K Reshetnyak , O A Andreev , U Lehnert , D M Engelman . . Proc Natl Acad Sci USA , 2006 . 103 ( 17 ): 6460 - 6465 . DOI:10.1073/pnas.0601463103http://doi.org/10.1073/pnas.0601463103.

J C Deacon , D M Engelman , F N Barrera . . Arch Biochem Biophys , 2015 . 565 40 - 48 . DOI:10.1016/j.abb.2014.11.002http://doi.org/10.1016/j.abb.2014.11.002.

J O Onyango , M S Chung , C H Eng , L M Klees , R Langenbacher , L Yao , M An . . Angew Chem , 2015 . 54 ( 12 ): 3658 - 3663 . DOI:10.1002/anie.201409770http://doi.org/10.1002/anie.201409770.

M Zoonens , Y K Reshetnyak , D M Engelman . . Biophys J , 2008 . 95 ( 1 ): 225 - 235 . DOI:10.1529/biophysj.107.124156http://doi.org/10.1529/biophysj.107.124156.

N S Shu , M S Chung , L Yao , M An , W Qiang . . Nat Commun , 2015 . 6 7787 DOI:10.1038/ncomms8787http://doi.org/10.1038/ncomms8787.

Z Zhao , H Meng , N Wang , M J Donovan , T Fu , M You , Z Chen , X Zhang , W Tan . . Angew Chem , 2013 . 52 ( 29 ): 7487 - 7491 . DOI:10.1002/anie.201302557http://doi.org/10.1002/anie.201302557.

E A Sosunov , E P Anyukhovsky , A A Sosunov , A Moshnikova , D Wijesinghe , D M Engelman , Y K Reshetnyak , O A Andreev . . Proc Natl Acad Sci USA , 2013 . 110 ( 1 ): 82 - 86 . DOI:10.1073/pnas.1220038110http://doi.org/10.1073/pnas.1220038110.

M Yu , F Guo , J Wang , F Tan , N Li . . ACS Appl Mater Interfaces , 2015 . 7 ( 32 ): 17592 - 17597 . DOI:10.1021/acsami.5b05763http://doi.org/10.1021/acsami.5b05763.

H Lee , J H Jeong , T G Park . . J Control Release , 2002 . 79 ( 1 ): 283 - 291 . http://test.europepmc.org/abstract/MED/11853938.

H Hatakeyama , E Ito , H Akita , M Oishi , Y Nagasaki , S Futaki , H Harashima . . J Control Release , 2009 . 139 ( 2 ): 127 - 132 . DOI:10.1016/j.jconrel.2009.06.008http://doi.org/10.1016/j.jconrel.2009.06.008.

F Q Schafer , G R Buettner . . Free Radic Biol Med , 2001 . 30 ( 11 ): 1191 - 1212 . DOI:10.1016/S0891-5849(01)00480-4http://doi.org/10.1016/S0891-5849(01)00480-4.

J Zhang , Z F Yuan , Y Wang , W H Chen , G F Luo , S X Cheng , R X Zhuo , X Z Zhang . . J Am Chem Soc , 2013 . 135 ( 13 ): 5068 - 5073 . DOI:10.1021/ja312004mhttp://doi.org/10.1021/ja312004m.

D Xiao , H Z Jia , J Zhang , C W Liu , R X Zhuo , X Z Zhang . . Small , 2014 . 10 ( 3 ): 591 - 598 . DOI:10.1002/smll.v10.3http://doi.org/10.1002/smll.v10.3.

Y Yuan , R T Kwok , G Feng , J Liang , J Geng , B Z Tang , B Liu . . Chem Commun (Camb) , 2014 . 50 ( 3 ): 295 - 297 . DOI:10.1039/C3CC47585Ahttp://doi.org/10.1039/C3CC47585A.

J Lee , H Kim , S Han , E Hong , K H Lee , C Kim . . J Am Chem Soc , 2014 . 136 ( 37 ): 12880 - 12883 . DOI:10.1021/ja507767hhttp://doi.org/10.1021/ja507767h.

T Suma , J Cui , M Mullner , S Fu , J Tran , K F Noi , Y Ju , F Caruso . . J Am Chem Soc , 2017 . 139 ( 11 ): 4009 - 4018 . DOI:10.1021/jacs.6b11302http://doi.org/10.1021/jacs.6b11302.

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