糖聚肽高分子的合成、自组装及生物医学应用

肖春生; 丁建勋; 贺超良; 陈学思

doi:10.11777/j.issn1000-3304.2018.17282

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糖聚肽高分子的合成、自组装及生物医学应用

综述 | 更新时间：2021-01-26

- 糖聚肽高分子的合成、自组装及生物医学应用
- Glycopolypeptides: Synthesis, Self-assembly and Biomedical Applications
- 高分子学报 2018年第1期页码：45-55
- 作者机构：
  
  中国科学院长春应用化学研究所中国科学院生态环境高分子重点实验室长春 130022
- 作者简介：
  
  陈学思, xschen@ciac.ac.cnXue-si Chen, xschen@ciac.ac.cn
- 基金信息：
  
  国家自然科学基金(51773196);国家自然科学基金(51573184);国家自然科学基金(51390484);国家自然科学基金(51520105004);中国科学院青年创新促进会项目(2017266)
- DOI：10.11777/j.issn1000-3304.2018.17282
  中图分类号：
- 纸质出版日期：2018-1-20，
  
  收稿日期：2017-10-7，
  
  修回日期：2017-11-12，
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肖春生, 丁建勋, 贺超良, 陈学思. 糖聚肽高分子的合成、自组装及生物医学应用[J]. 高分子学报, 2018,(1):45-55.

Xiao Chun-sheng, Ding Jian-xun, He Chao-liang, Chen Xue-si. Glycopolypeptides: Synthesis, Self-assembly and Biomedical Applications[J]. Acta Polymerica Sinica, 2018,(1):45-55.
肖春生, 丁建勋, 贺超良, 陈学思. 糖聚肽高分子的合成、自组装及生物医学应用[J]. 高分子学报, 2018,(1):45-55. DOI： 10.11777/j.issn1000-3304.2018.17282.

Xiao Chun-sheng, Ding Jian-xun, He Chao-liang, Chen Xue-si. Glycopolypeptides: Synthesis, Self-assembly and Biomedical Applications[J]. Acta Polymerica Sinica, 2018,(1):45-55. DOI： 10.11777/j.issn1000-3304.2018.17282.

摘要

糖聚肽高分子是一类由聚肽（也称聚氨基酸）和糖类化合物（包括单糖、寡糖和多糖）构成的生物可降解高分子.糖聚肽高分子具有与天然糖蛋白分子类似的化学组成，能够在一定程度上模拟天然糖蛋白的结构和性能，近年来引起了学术界的广泛研究兴趣.本文总结了糖聚肽高分子的合成方法及其在水溶液中的自组装行为，并着重评述了糖聚肽高分子在生物分子识别、靶向基因/药物传输和组织工程支架等生物医学领域中的应用.

Abstract

Glycopolypeptides are a kind of biodegradable polymers consisting of polypeptides (polyamino acid) and carbohydrates (such as monosaccharide

oligosaccharides and polysaccharides). Owing to their chemical similarity to glycoproteins

glycopolypeptides can

to some extent

mimic the structure and function of natural glycoproteins

and have attracted broad attention recently. Two general strategies have been developed for the synthesis of glycopolypeptides

i.e.

direct polymerization of glycosylated monomers and post-polymerization glycosylation of reactive polypeptides. Although the synthesis of glycopolypeptides can be traced back to sixty years ago

the synthesis of glycopolypeptides with Control architectures and high molecular weights can be achieved when high purified sugar-substituted amino acid

-carboxyanhydride (NCA) monomers for Control ring-opening polymerization and "clickable" polypeptides for "click" glycosylation have been extensively developed. Based on these advances on Control synthesis of glycopolypeptides

many efforts are devoted to studying the self-assembly of amphiphilic glycopolypeptide (co)polymers into various nano-structures

such as micelles

vesicles and nanorods. More interestingly

hierarchical self-assembly of an alternating amphiphilic glycopolypeptide to mimic the complex structure of natural glycoconjugates also has been achieved. In addition

as a kind of structural mimics of natural glycoproteins

the synthetic glycopolypeptides are capable of binding selectively to various carbohydrate-binding proteins

such as lectins. And the lectin-binding ability is confirmed to be dependent on the type

composition

density and distribution pattern of the sugar residues on the polypeptide backbone. Also

due to the presence of carbohydrate-binding proteins on cell surfaces

especially on the surface of cancer cells

glycopolypeptides have been widely investigated as biocompatible nanocarrieres for targeted drug/gene delivery. Most recently

glycopolypeptides-based hydrogels are receiving increasing attention for tissue engineering applications because of their ability to enhance cell adhesion and proliferation in 3D cell culture. In this article

we summarize recent advances in the synthesis and self-assembly of glycopolypeptides

and their applications in biomedical fields

such as biomolecular recognitions

targeted gene/drug delivery and scaffolds for tissue engineering

are also emphatically reviewed and discussed.

关键词

糖聚肽聚氨基酸开环聚合自组装生物医学应用

Keywords

GlycopolypeptidesPolypeptidesRing-opening polymerizationSelf-assemblyBiomedical applications

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