用于基因传递的智能响应性高分子研究进展

陈思; 鄢国平; 张先正

doi:10.11777/j.issn1000-3304.2018.17313

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用于基因传递的智能响应性高分子研究进展

综述 | 更新时间：2021-01-26

- 用于基因传递的智能响应性高分子研究进展
- Intelligent Responsive Polymers for Gene Delivery
- 高分子学报 2018年0卷第7期页码：853-863
- 作者机构：
  
  1.武汉工程大学材料科学与工程学院　武汉 430205
  2.生物医用高分子材料教育部重点实验室武汉大学化学与分子科学学院　武汉 430072
- 作者简介：
  
  E-mail: xz-zhang@whu.edu.cn Xian-zheng Zhang, E-mail: xz-zhang@whu.edu.cn
- 基金信息：
  
  国家自然科学基金(基金号 21474077)和湖北省教育厅科学技术研究项目(项目号 Q20171509)资助()
- DOI：10.11777/j.issn1000-3304.2018.17313
  中图分类号：
- 纸质出版日期：2018-7，
  
  收稿日期：2017-11-15，
  
  修回日期：2017-12-11，
扫描看全文
陈思, 鄢国平, 张先正. 用于基因传递的智能响应性高分子研究进展[J]. 高分子学报, 2018,0(7):853-863.

Si Chen, Guo-ping Yan, Xian-zheng Zhang. Intelligent Responsive Polymers for Gene Delivery[J]. Acta Polymerica Sinica, 2018,0(7):853-863.
陈思, 鄢国平, 张先正. 用于基因传递的智能响应性高分子研究进展[J]. 高分子学报, 2018,0(7):853-863. DOI： 10.11777/j.issn1000-3304.2018.17313.

Si Chen, Guo-ping Yan, Xian-zheng Zhang. Intelligent Responsive Polymers for Gene Delivery[J]. Acta Polymerica Sinica, 2018,0(7):853-863. DOI： 10.11777/j.issn1000-3304.2018.17313.

摘要

智能响应性高分子由于具有优异的环境响应性、多样的功能性、良好的生物可降解性和生物相容性而在生物医用领域备受瞩目. 基于特定功能的智能响应性高分子基因载体可以克服基因运载中的障碍，降低对正常组织和细胞的毒副作用，提升靶细胞的基因转染效率. 此外，大部分智能响应性高分子能有效结合多种治疗方式以实现更有效的治疗效果. 本文综述了近年来智能响应性高分子在基因运载及相关生物医用领域的研究进展，对相关智能响应性高分子的设计及特点进行了介绍，并进一步对其在基因运载及相关生物医用领域的应用前景进行了展望.

Abstract

Gene therapy is a remarkable technique which regulates specific gene expression in targeted cells to treat acquired and inherited diseases

via

exogenous nucleic acids. However

naked genes could hardly be utilized directly due to their large size

low stability in circulation and poor cellular uptake. Therefore

suitable gene vector plays a crucial role in gene therapy. Though a mass of gene delivery systems have been developed and shown extraordinary potential to treat gene-related diseases

the clinical applications of gene therapy are still limited by various biological barriers. These barriers include DNA packaging

bloodstream clearing

non-specific cellular uptake

cytomembrane obstructing

endosomal escape

DNA release and potential toxicity to normal tissues

etc

. In order to overcome these barriers

the gene vectors should satisfy numerous requirements

including effective gene packaging

prolonging the circulation time in bloodstream

excellent targeting ability

the endosomal escape capability

reduced vector-induced toxicity and the capacity of stimuli-responsive gene unpacking

etc

. Intelligent responsive polymers have attracted increasing research attentions in gene delivery applications due to their excellent responsiveness

superadditive versatility

prominent biodegradability and superb biocompatibility

etc

. Thus

utilizing the intelligent responsive polymers with special functions could overcome a series of barriers in gene delivery. In addition

most intelligent responsive polymers can creatively combine multiple treatments for tumor therapy to achieve more effective therapeutic effects. This review highlights the designs

characteristics as well as biomedical applications of intelligent responsive polymers in gene delivery field in recent years. The types of response in intelligent responsive polymers include pH response

reduction response

enzyme response

light response and multiple response

etc

. The research trends and prospects of these polymers are also discussed. In order to push forward the studies of intelligent responsive polymers in gene delivery field and to develop novel gene vectors

more research attention should be paid to responsive polymers with proper chemical properties

suitable physical properties

desired architectures and appropriate functions.

关键词

智能响应性高分子基因传递pH响应还原响应酶响应光响应

Keywords

Intelligent responsive polymerGene deliverypH ResponsiveReduction responsiveEnzyme responsiveLight-responsive

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