序列可控高分子的合成及应用

张留乔; 黄智豪; 张正彪; 朱秀林

doi:10.11777/j.issn1000-3304.2018.18101

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序列可控高分子的合成及应用

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- 序列可控高分子的合成及应用
- Synthesis and Application of Sequence-controlled Polymers
- 高分子学报 2018年0卷第9期页码：1144-1154
- 作者机构：
  
  苏州大学材料与化学化工学部　苏州 215123
- 作者简介：
  
  [ "张正彪，男，1974年出生. 博士，苏州大学材料与化学化工学部教授，分别于1997年、2000年和2007年在苏州大学获得学士、硕士和博士学位. 2007年8月 ~ 2008年8月赴新加坡国立大学做博士后研究一年；2012年 ~ 2013年赴美国阿克伦大学高分子科学与工程学院做访问学者；2015年6月 ~ 8月赴日本名古屋大学做访问教授. 主要研究领域为高分子可控/精准合成、功能高分子的设计和合成. 近年来，已在Angew. Chem. Int. Ed.，Macromolecules，Polym. Chem.等刊物发表研究论文80余篇" ]
- 基金信息：
  
  国家自然科学基金(基金号 21674072)资助项目()
- DOI：10.11777/j.issn1000-3304.2018.18101
  中图分类号：
- 纸质出版日期：2018-9，
  
  收稿日期：2018-4-9，
  
  修回日期：2018-5-2，
扫描看全文
张留乔, 黄智豪, 张正彪, 朱秀林. 序列可控高分子的合成及应用[J]. 高分子学报, 2018,0(9):1144-1154.

Liu-qiao Zhang, Zhi-hao Huang, Zheng-biao Zhang, Xiu-lin Zhu. Synthesis and Application of Sequence-controlled Polymers[J]. Acta Polymerica Sinica, 2018,0(9):1144-1154.
张留乔, 黄智豪, 张正彪, 朱秀林. 序列可控高分子的合成及应用[J]. 高分子学报, 2018,0(9):1144-1154. DOI： 10.11777/j.issn1000-3304.2018.18101.

Liu-qiao Zhang, Zhi-hao Huang, Zheng-biao Zhang, Xiu-lin Zhu. Synthesis and Application of Sequence-controlled Polymers[J]. Acta Polymerica Sinica, 2018,0(9):1144-1154. DOI： 10.11777/j.issn1000-3304.2018.18101.

摘要

序列可控高分子是指高分子链中不同单体单元按特定顺序排列的高分子. 自然界中的生物大分子，如核酸分子和多肽，其精确的序列结构决定了其复杂功能的表达. 受此启发，序列可控高分子的合成及序列结构与性能关系研究近年来受到了越来越多的关注. 本文介绍了近年来在序列可控高分子合成方面的重要研究成果，突出介绍了本课题组在序列可控高分子方向的研究进展. 最后，对序列可控高分子的应用进行了总结和展望.

Abstract

Sequence-controlled polymers are those with ordered units along their chains. The precision sequence of biological polymers

such as nucleic acid and peptides

plays a crucial role on physiological and sophisticated functions. Inspired by this

the synthesis of sequence-controlled polymers

that is

the placement of specific functional groups at desired positions on the polymer chain

has become one of the ultimate goals of polymer chemists

and received increasing attention in recent years. Up to date

there are a variety of methods to synthesize sequence-controlled polymers based on the step-growth and chain-growth polymerization mechanisms. Compared to the step-growth polymerization

the chain-growth polymerization is much more challenging to achieve sequence-controlled polymers because of the high activity and low propagating selectivity of the growing active center. Therefore

sequence-controlled polymerization is also considered as the " Holy Grail” in the field of polymer synthesis. Although a variety of methods have been developed to regulate polymer sequences

the pursuit of simple and efficient methods toward sequence-controlled polymerization has never stopped. This feature article summarizes the recent progresses on the synthesis of sequence-controlled polymers

and highlights our group’s research in this area. Firstly

we built " supramolecular monomer” by exploiting the weak intermolecular hydrogen-bond interactions to create sequences with alternating feature. We also developed a " latent monomer” strategy based on the temperature-dependent furan/maleimide Diels-Alder reaction

and diverse sequence-controlled polymers were thus readily created. Moreover

a novel chemical route

based on orthogonal chain end deprotection and thiol-maleimide Michael addition

was developed in our group toward the monodisperse and sequence-defined polymers. Finally

the potential applications of the sequence-controlled polymers are also summarized and prospected.

关键词

序列可控高分子可控自由基聚合迭代增长马来酰亚胺Diels-Alder反应

Keywords

Sequence-controlled polymerControlled radical polymerizationIterative growthMaleimideDiels-Alder reaction

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