抗菌杂化SiO<sub>2</sub>纳米粒子的制备及在聚氨酯中的应用研究

施申伟; 李婷; 汪洋; 东为富

doi:10.11777/j.issn1000-3304.2019.19009

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抗菌杂化SiO₂纳米粒子的制备及在聚氨酯中的应用研究

研究论文 | 更新时间：2021-01-26

- 抗菌杂化SiO₂纳米粒子的制备及在聚氨酯中的应用研究
- Preparation of Antibacterial Hybrid Silica Nanoparticle and Its Application in Polyurethane
- 高分子学报 2019年50卷第7期页码：721-729
- 作者机构：
  
  合成与生物胶体教育部重点实验室江南大学　无锡 214122
- 作者简介：
  
  E-mail: wfdong@jiangnan.edu.cn Wei-fu Dong, E-mail: wfdong@jiangnan.edu.cn
- 基金信息：
  
  国家自然科学基金(基金号 51373070)资助项目()
- DOI：10.11777/j.issn1000-3304.2019.19009
  中图分类号：
- 纸质出版日期：2019-7，
  
  网络出版日期：2019-3-19，
  
  收稿日期：2019-1-11，
  
  修回日期：2019-1-30，
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施申伟, 李婷, 汪洋, 东为富. 抗菌杂化SiO₂纳米粒子的制备及在聚氨酯中的应用研究[J]. 高分子学报, 2019,50(7):721-729.

Shen-wei Shi, Ting Li, Yang Wang, Wei-fu Dong. Preparation of Antibacterial Hybrid Silica Nanoparticle and Its Application in Polyurethane[J]. Acta Polymerica Sinica, 2019,50(7):721-729.
施申伟, 李婷, 汪洋, 东为富. 抗菌杂化SiO₂纳米粒子的制备及在聚氨酯中的应用研究[J]. 高分子学报, 2019,50(7):721-729. DOI： 10.11777/j.issn1000-3304.2019.19009.

Shen-wei Shi, Ting Li, Yang Wang, Wei-fu Dong. Preparation of Antibacterial Hybrid Silica Nanoparticle and Its Application in Polyurethane[J]. Acta Polymerica Sinica, 2019,50(7):721-729. DOI： 10.11777/j.issn1000-3304.2019.19009.

摘要

采用价格低廉的硅烷偶联剂制备了反应性季铵化合物(QAC)，并用简单的方法将QAC一步接枝在SiO

上，制备抗菌杂化SiO

纳米粒子. 首先研究了杂化SiO

纳米粒子的化学结构、微观形貌以及抗菌性能. 进一步将杂化SiO

纳米粒子与聚氨酯复合，并固化成膜. 研究了复合薄膜的抗菌性能、力学性能以及抗菌持久性，并对其进行了抑菌圈测试. 结果表明：与纯SiO

纳米粒子相比，杂化SiO

纳米粒子具有优异的抗菌性能，可以在20 min内完全灭杀大肠杆菌与表皮葡萄球菌. 杂化SiO

纳米粒子易在薄膜表面富集，仅添加少量(5 wt%)的杂化SiO

纳米粒子便可使薄膜获得良好的抗菌性能以及较高的拉伸强度；对复合薄膜进行加速老化处理后，仍具有良好的抗菌性能，表明该复合薄膜具有良好的抗菌持久性与稳定性；抑菌圈的测试表明，复合薄膜为接触型抗菌材料，无抗菌物质浸出，更加安全高效.

Abstract

A series of reactive QACs with different chain lengths were prepared by inexpensive tertiary amine silane coupling agent

which were covalently grafted onto the surface of SiO

nanoparticles in one step

via

a modified Stöber method. This method can increase the graft ratio of QAC relative to the use of dry silica powder. The structure and appearance of hybrid SiO

nanoparticles were studied by Fourier transform infrared spectroscopy (FTIR)

transmission electron microscopy (TEM)

zeta potential and thermogravimetric analysis (TGA). The antibacterial activity of hybrid SiO

nanoparticles was evaluated by shake flask method. The composite films with excellent antimicrobial properties were obtained from a mixture of a polyurethane acrylate prepolymer and hybrid SiO

nanoparticles

via

UV curing. The standard antibacterial test method ISO 22196 was used to evaluate the antibacterial properties of the film. The results showed that the hybrid SiO

nanoparticles have a uniform particle size (~ 40 nm)

a smooth spherical shape and a high positive charge on the surface. Antibacterial test results indicated that the hybrid SiO

nanoparticles have excellent antibacterial activity compared with pure SiO

nanoparticles

and can completely killed

Escherichia coli

and

Staphylococcus epidermidis

in 50 min. As the QAC alkyl chain grows

the antibacterial properties of the nanoparticles are further improved and SiO

-Q-12 can killed two bacteria completely within 20 min. This is mainly due to the hybrid SiO

nanoparticles are light and have a high positive charge on the surface

so they can be quickly adsorbed on the surface of bacteria to achieve rapid sterilization. The hybrid SiO

nanoparticles were enriched on the surface of the film. Adding a small amount (5 wt%) of hybrid SiO

nanoparticles could endow the film with good antibacterial properties and high tensile strength. After the accelerated aging treatment of the composite film according to the national standard GB 15979-2002

it still possessed good antibacterial properties

indicating that the composite film has excellent antibacterial durability and stability. The test of the inhibition zone showed that the composite film was a contact antibacterial material

no antibacterial substance leaching

which was safer and more efficient.

关键词

共价接枝杂化SiO2表面富集接触型抗菌

Keywords

Covalent graftingHybrid SiO2Surface enrichmentContact antibacterial

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抗菌杂化SiO2纳米粒子的制备及在聚氨酯中的应用研究

Preparation of Antibacterial Hybrid Silica Nanoparticle and Its Application in Polyurethane

DOI：10.11777/j.issn1000-3304.2019.19009

摘要

Abstract

关键词

Keywords

references

抗菌杂化SiO₂纳米粒子的制备及在聚氨酯中的应用研究