医用材料表界面设计及其与细胞相互作用

王蓉; 沈新坤; 胡燕; 蔡开勇

doi:10.11777/j.issn1000-3304.2019.19085

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医用材料表界面设计及其与细胞相互作用

专论 | 更新时间：2021-01-26

- 医用材料表界面设计及其与细胞相互作用
- Surface/Interface Design of Medical Materials and Their Interactions with Cells
- 高分子学报 2019年50卷第9期页码：863-872
- 作者机构：
  
  重庆大学生物工程学院　重庆 400044
- 作者简介：
  
  [ "蔡开勇，男，1973年生，重庆大学教授、博士生导师. 2002年毕业于天津大学，获生物医学工程学博士学位，随后在德国从事博士后研究，2005年加入重庆大学. 先后获评教育部新世纪优秀人才(2007年)、霍英东青年教师基金(基础研究)(2010年)、第十二届中国青年科技奖(2011年)、重庆市杰出青年科学基金(2011年)、教育部长江学者特聘教授(2012年)、国务院政府特殊津贴专家(2014年)、重庆市自然科学一等奖(排名第一、2015年)、“生物材料与组织修复”重庆高校创新团队带头人(2016年)、国家百千万人才工程入选者(2017年)、国家杰出青年科学基金(2018年)等奖励及人才计划. 主要研究方向为医用钛及钛合金材料及其表界面与细胞的相互作用、刺激响应性纳米药物控释系统" ]
- 基金信息：
  
  国家自然科学基金(基金号 51825302，21734002，51673032)资助项目()
- DOI：10.11777/j.issn1000-3304.2019.19085
  中图分类号：
- 纸质出版日期：2019-9，
  
  网络出版日期：2019-7-12，
  
  收稿日期：2019-4-25，
  
  修回日期：2019-6-5，
扫描看全文
王蓉, 沈新坤, 胡燕, 蔡开勇. 医用材料表界面设计及其与细胞相互作用[J]. 高分子学报, 2019,50(9):863-872.

Rong Wang, Xin-kun Shen, Yan Hu, Kai-yong Cai. Surface/Interface Design of Medical Materials and Their Interactions with Cells[J]. Acta Polymerica Sinica, 2019,50(9):863-872.
王蓉, 沈新坤, 胡燕, 蔡开勇. 医用材料表界面设计及其与细胞相互作用[J]. 高分子学报, 2019,50(9):863-872. DOI： 10.11777/j.issn1000-3304.2019.19085.

Rong Wang, Xin-kun Shen, Yan Hu, Kai-yong Cai. Surface/Interface Design of Medical Materials and Their Interactions with Cells[J]. Acta Polymerica Sinica, 2019,50(9):863-872. DOI： 10.11777/j.issn1000-3304.2019.19085.

摘要

正常生理状态下，细胞/组织具有特定的微环境维持其相关功能，这种环境中存在着大量功能分子. 在病理条件下，组织/器官的缺损或病变会导致细胞/组织微环境破坏、生理信号异常. 因此，在生物医用材料界面模拟正常状态下细胞/组织微环境、重构其成分和形态、实现损伤组织的修复是生物医用材料表界面设计的宗旨. 为了改善医用材料的生物惰性、提高修复材料基材的生物相容性、丰富材料的生物学功能，最终实现仿生效果，表界面修饰手段已成为人们的研究热点. 材料表界面的修饰不仅可以改善惰性材料与宿主的缺乏交流的问题，还可保留材料的基本物理性质. 在我们的研究中，利用细胞/组织生理和病理微环境指导功能化修复材料表界面的设计，通过高分子修饰途径，仿生制备出了系列促成骨、促基因转染、抗菌、抗肿瘤等具有广泛应用前景的生物材料. 本文对近年来的相关研究工作进行了总结，并对该领域存在的挑战进行了展望.

Abstract

Under healthy conditions

cells/tissues can function normally in their natural microenvironment due to the large amount of biomolecules herein. However

the normal cell/tissue microenvironment will be disrupted after certain pathological events due to the loss and damage associated with certain biological entities

and the disrupted microenvironment is usually accompanied by abnormal biological signals. Therefore

when designing biomaterials

one of the primary considerations is to restore the healthy cell/tissue microenvironment at the tissue-biomaterial interface and reconstruct the original biological structures

in situ

by mimicking human tissues

which is of critical importance to the total repair of the disease site. However

most of the existing biomaterials are biologically inert and lack interaction with the host. To improve the biocompatibility and biofunctionality of the substrate materials and to enhance their biomimeticity

the surface modification technology has gained increasing interest in recent decades. The rational modification of the tissue-biomaterial interface can improve beneficial interaction between the substrate material

while still preserving the physical properties of the material that are favorable for certain applications. Based on our previous study on cell/tissue biological and pathological environment

our group has carried out a lot research on the development of new biofunctional interfaces using polymer-based ligands or functional moieties

of which properties could be tailored according to the specific characteristics of particular microenvironment. The as-developed biomaterials could fulfill a variety of roles including osteogenic promotion

gene transfection

antibacterial and antitumor applications. It was also confirmed that these polymer-modified materials can autonomously interact with the biological tissues and execute the designed biological functions in a highly responsive manner. With the advances in synthesis chemistry and processing technology

new biomimetic materials with better fineness and structural precision will attract greater interest in related areas. In this paper

we will summarize the relevant research work in recent years and discuss those existing challenges.

关键词

微环境表界面设计高分子层骨修复肿瘤治疗

Keywords

MicroenvironmentsSurface/Interface designPolymer layerBone repairCancer therapy

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