合成高分子基温敏水凝胶在眼病治疗中的研究进展

刘敏华; 南开辉; 陈杨军

doi:10.11777/j.issn1000-3304.2020.20152

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合成高分子基温敏水凝胶在眼病治疗中的研究进展

综述 | 更新时间：2021-05-15

- 合成高分子基温敏水凝胶在眼病治疗中的研究进展
- The Progress in Thermogels Based on Synthetic Polymers for Treating Ophthalmic Diseases
- 高分子学报 2021年52卷第1期页码：47-60
- 作者机构：
  
  1. 温州医科大学眼视光学院附属眼视光医院
  2. 眼视光学和视觉科学国家重点实验室　温州 325027
- 作者简介：
  
  [ "南开辉，男，1974年生. 研究员，博士生导师，浙江省中青年学科带头人，温州市特支计划科技创新领军人才. 2000~2005年于华南理工大学材料与科学工程学院获得博士学位，2007年进入温州医科大学眼视光学院，2012~2014年加州大学圣地亚哥分校Shiley Eye Center访问学者. 主要从事组织工程化眼组织修复、药物靶向缓控释技术及载体材料开发等生物材料眼科转化应用方面研究" ]
  [ "陈杨军，男，1989年生. 2007~2016年于浙江大学高分子科学与工程学系获得学士、博士学位，导师为计剑教授；2017~2018年在加拿大Alberta大学化学与材料工程学系从事博士后研究，导师为Ravin Narain教授. 2019年1月起，温州医科大学眼视光学院，附属眼视光医院任助理研究员. 主要从事智能纳米药物载体，可注射生物医用水凝胶等方面的研究" ]
- 基金信息：
  
  国家重点研发计划项目(项目号 2016YFC1101201)、浙江省自然科学基金(基金号 LQ20E030010)、省部共建眼视光学和视觉科学国家重点实验室资助项目(项目号 J02-20190202)和温州市基础性科研项目(项目号 Y20180230)资助()
- DOI：10.11777/j.issn1000-3304.2020.20152
  中图分类号：
- 纸质出版日期：2021-1-3，
  
  网络出版日期：2020-8-28，
  
  收稿日期：2020-6-10，
  
  修回日期：2020-7-8，
扫描看全文
刘敏华, 南开辉, 陈杨军. 合成高分子基温敏水凝胶在眼病治疗中的研究进展[J]. 高分子学报, 2021,52(1):47-60.

Min-hua Liu, Kai-hui Nan, Yang-jun Chen. The Progress in Thermogels Based on Synthetic Polymers for Treating Ophthalmic Diseases[J]. Acta Polymerica Sinica, 2021,52(1):47-60.
刘敏华, 南开辉, 陈杨军. 合成高分子基温敏水凝胶在眼病治疗中的研究进展[J]. 高分子学报, 2021,52(1):47-60. DOI： 10.11777/j.issn1000-3304.2020.20152.

Min-hua Liu, Kai-hui Nan, Yang-jun Chen. The Progress in Thermogels Based on Synthetic Polymers for Treating Ophthalmic Diseases[J]. Acta Polymerica Sinica, 2021,52(1):47-60. DOI： 10.11777/j.issn1000-3304.2020.20152.

摘要

由于眼部存在角膜/结膜屏障、血-房水屏障和血-视网膜屏障等，有效的眼部给药依然面临巨大挑战. 近年来，温敏水凝胶在眼部给药领域受到了广泛关注. 在室温下，温敏水凝胶材料呈液态，便于以局部滴加或玻璃体内注射的方式给药；当与眼部接触升温并超过其临界成胶温度时，能以物理交联的方式快速凝胶化，从而实现原位缓释给药，提高药物生物利用度. 在众多温敏水凝胶材料中，合成高分子具有材料和功能多样化等优势，其中较常见的为泊洛沙姆、聚乙二醇/聚酯和聚(

-异丙基丙烯酰胺). 本综述首先介绍了以上3类合成高分子基温敏水凝胶材料的制备方法和成胶特性. 然后，围绕眼部给药存在的难点，探讨这些温敏水凝胶在治疗角膜病、干眼症、青光眼和眼部炎症等各种眼病中的相关研究进展. 最后，我们比较了这3种水凝胶在使用性能上的优缺点，并对未来眼科温敏水凝胶的材料设计提出了设想和展望.

Abstract

Due to the presence of several physiological barriers

including corneal barrier

blood-aqueous humor barrier and blood-retinal barrier

efficient drug delivery remains a huge challenge in the treatment of ocular diseases. In recent years

in situ

forming thermogels have emerged as ideal drug delivery systems (DDSs) with sustained-release feature

receiving extensive attention in the field of ocular drug delivery. At room temperature

thermogels in liquid form can be easily administrated by topical instillation or intravitreal injection. Once in contact with the eye

physical crosslinking induced sol-gel transition will take place

in-situ

when the liquid temperature exceeds the critical gelation temperature. Thus

drug retention time can be prolonged and drugs can be continuously released for a longer term to enhance drug bioavailability. Benefiting from the advantages of synthetic polymers in terms of material diversity and versatility

thermogels based on synthetic polymers are the current hotspot in the research of temperature-induced hydrogels. Poloxamer

polyethylene glycol/polyester and poly(

-isopropylacrylamide) are the three most common synthetic thermo-gelling polymers. In this review

we will first introduce preparation methods and gel-forming properties of these synthetic polymer-based thermogels. Then

the research progress of the application of synthetic thermogels in the treatment of ophthalmic diseases

including corneal disorders

dry eye syndrome

glaucoma

ocular inflammation

and others

is mainly discussed. Last but not the least

the advantages and disadvantages of these three thermogels are compared

and future perspectives on the design of novel synthetic thermogels for ophthalmic applications are suggested.

关键词

合成高分子温敏水凝胶眼病治疗可注射药物缓释

Keywords

Synthetic polymerThermogelOphthalmic treatmentInjectableSustained drug release

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