基于原子力显微镜的单分子力谱技术在高分子表征中的应用

张薇; 侯矍; 李楠; 张文科

doi:10.11777/j.issn1000-3304.2020.20266

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基于原子力显微镜的单分子力谱技术在高分子表征中的应用

综述 (高分子表征技术专题) | 更新时间：2022-07-08

- 基于原子力显微镜的单分子力谱技术在高分子表征中的应用
- Application of Atomic Force Microscopy (AFM)-based Single-molecule Force Spectroscopy (SMFS) in Polymer Characterization
- 高分子学报 2021年52卷第11期页码：1523-1546
- 作者机构：
  
  吉林大学超分子结构与材料国家重点实验室长春 130012
- 作者简介：
  
  [ "张文科，男，1973年生. 分别于1997、2002年在吉林大学化学系(学院)获得学士、博士学位，导师为张希教授；2001~2002年于德国慕尼黑大学(LMU)博士联合培养，导师为Hermann E. Gaub教授；2003~2007年于英国诺丁汉大学从事博士后研究. 2007年6月至今，吉林大学超分子结构与材料国家重点实验室教授. 2011年入选教育部“新世纪优秀人才支持计划”；2015年获得国家杰出青年基金资助. 以原子力显微镜及磁镊等技术，从单个分子水平开展超分子作用力及大分子组装结构与组装过程研究，主要研究方向包括：单分子力谱与超分子组装、高分子结晶及力致熔融、核酸-蛋白相互作用、聚合物力化学等." ]
- 基金信息：
  
  国家自然科学基金(基金号 ┣21525418);21827805┫
- DOI：10.11777/j.issn1000-3304.2020.20266
  中图分类号：
- 纸质出版日期：2021-11-20，
  
  网络出版日期：2021-05-21，
  
  收稿日期：2020-12-07，
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张薇,侯矍,李楠等.基于原子力显微镜的单分子力谱技术在高分子表征中的应用[J].高分子学报,2021,52(11):1523-1546.

Zhang Wei,Hou Jue,Li Nan,et al.Application of Atomic Force Microscopy (AFM)-based Single-molecule Force Spectroscopy (SMFS) in Polymer Characterization[J].ACTA POLYMERICA SINICA,2021,52(11):1523-1546.
张薇,侯矍,李楠等.基于原子力显微镜的单分子力谱技术在高分子表征中的应用[J].高分子学报,2021,52(11):1523-1546. DOI： 10.11777/j.issn1000-3304.2020.20266.

Zhang Wei,Hou Jue,Li Nan,et al.Application of Atomic Force Microscopy (AFM)-based Single-molecule Force Spectroscopy (SMFS) in Polymer Characterization[J].ACTA POLYMERICA SINICA,2021,52(11):1523-1546. DOI： 10.11777/j.issn1000-3304.2020.20266.

摘要

基于原子力显微镜(atomic force microscopy

AFM)的单分子力谱技术以其操作简便、适用面广等优势，成为了单分子领域应用最为广泛的技术之一. 本文阐述了该技术的基础原理与实验技巧，包括仪器构造、工作原理、探针与基底的选择、样品固定、实验操作、单分子信号的获得以及数据处理. 介绍了基于AFM的单分子力谱技术在合成高分子及生物大分子表征中的典型应用及前沿进展. AFM单分子力谱技术将有助于建立合成高分子的链结构、链组成与单链弹性以及链间相互作用与其宏观力学性能间的关联，帮助理解生物大分子的结构、相互作用与其生物功能之间的联系.

Abstract

Atomic force microscopy (AFM)-based single-molecule force spectroscopy (SMFS) has been used widely in the investigation of molecular forces because of its friendly user interface (

e.g.

easy to operate and can work in liquid

air and high vacuum phase) and worldwide commercialization. This review is aimed to introduce the principle and protocol of AFM-based SMFS including the setup

the working principle

typical curves

the choice of AFM tip and substrate

immobilization of samples

manipulation of the device

empirical criteria for single-molecule stretching and data analysis. Recent progresses on the application of AFM-based SMFS in the characterization of synthetic polymers and biopolymers were reviewed. For synthetic polymers

the effects of primary chemical compositions

side groups

tacticity and solvents on the single chain elasticities were discussed. The applications of AFM-SMFS in disclosing the structure of unknown molecule

polymer-interface interactions and polymer interactions in polymer assemblies (

e.g.

polymer single crystal) were introduced. In addition

the nature of mechanochemical reactions and characterization of supramolecular polymers were realized

via

this technic. For biopolymers

the effects of base-pair number

the force-loading mode (unzipping or shearing) on the stability of short double-stranded DNA (dsDNA) were reviewed. According to this knowledge

the single-molecule cut-and-paste based DNA assembly was then discussed. The typical force fingerprints of long dsDNA

proteins and polysaccharides as well as the force-fingerprint-based investigation of molecular interactions were illustrated. Finally

the application of AFM-SMFS in revealing the intermolecular interactions and the mechanism of virus disassembly as well as the antivirus mechanism of tannin in tobacco mosaic virus were reviewed.Therefore

AFM-based SMFS is essential for revealing the relationship between the conformation/composition of polymer chains and micro/macro-mechanical properties of polymer materials as well as correlating the molecular structure/interaction of biopolymers with their biofunctions.

关键词

AFM单分子力谱合成高分子生物大分子

Keywords

Atomic force microscopy-based single-molecule force spectroscopySynthetic polymersBiopolymers

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