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氮丙啶衍生物与环状酸酐共聚合成聚酯酰胺
Copolymerization of Aziridine Derivatives and Cyclic Anhydrides to Form Poly(ester amide)s
- 高分子学报 2021年52卷第7期 页码：717-722
- 作者机构：
精细化工国家重点实验室 大连理工大学化工学院 大连 116024
- 作者简介：
E-mail: wmren@dlut.edu.cn
- 基金信息：国家自然科学基金(基金号 21722402)
DOI：10.11777/j.issn1000-3304.2021.21011
中图分类号：纸质出版日期：2021-07-20，
网络出版日期：2021-05-25，
收稿日期：2021-01-13，
修回日期：2021-02-02，
扫 描 看 全 文
刘文静,乐天俊,任伟民.氮丙啶衍生物与环状酸酐共聚合成聚酯酰胺[J].高分子学报,2021,52(07):717-722.
Wen-jing Liu, Tian-jun Yue, Wei-min Ren. Copolymerization of Aziridine Derivatives and Cyclic Anhydrides to Form Poly(ester amide)s[J]. ACTA POLYMERICA SINICA, 2021,52(7):717-722.
刘文静,乐天俊,任伟民.氮丙啶衍生物与环状酸酐共聚合成聚酯酰胺[J].高分子学报,2021,52(07):717-722. DOI： 10.11777/j.issn1000-3304.2021.21011.
Wen-jing Liu, Tian-jun Yue, Wei-min Ren. Copolymerization of Aziridine Derivatives and Cyclic Anhydrides to Form Poly(ester amide)s[J]. ACTA POLYMERICA SINICA, 2021,52(7):717-722. DOI： 10.11777/j.issn1000-3304.2021.21011.
摘要
开发高效合成聚酯酰胺的方法一直是该领域研究的重点和难点. 本文发展了一种以有机碱为催化剂，以苄醇为引发剂，先通过易合成的氮丙啶衍生物与环状酸酐反应得到
N
-取代的共聚物，再通过氧化法由K
2
S
2
O
8
/Na
2
HPO
4
体系脱去氮原子上取代基从而合成聚酯酰胺的新方法. 通过该方法合成了9种不同结构的聚酯酰胺，为其在生物医学领域的应用提供了新的选择.
Abstract
Poly(ester amide)s (PEAs) are important synthetic polymeric materials. The excellent biodegradability and mechanical properties make the synthesis of such kinds polymers a research hotspot in the field of polymer chemistry. Herein
we report a novel strategy for accessing PEAs
via
the alternating copolymerization of easily synthesized aziridine derivatives and cyclic anhydrides with binary catalytic system consisting of benzyl alcohol (BnOH) and organic base (7-methyl-1
5
7-triazabicyclo[4.4.0]dec-5-ene (MTBD)) as catalyst
followed by the deprotection for the substitutes on the N atoms groups of the resultant copolymers using K
2
S
2
O
8
/Na
2
HPO
4
system. A detailed study on the debenzylation reaction was carried out. It was found that the K
2
S
2
O
8
/Na
2
HPO
4
system can effectively realize the debenzylation reaction involving the copolymer from 2
4-dimethoxy
-N
-benzylaziridine. The nine kinds of PEAs with different structures were synthesized from two types of monomers. The metal-free strategy
give these PEAs the potential to be utilized as hydrogels
tissue engineering
elastomers and smart materials as well as high-performance engineering plastics. Studies focused on further expanding the monomer scope and controlling the stereochemistry are currently in progress.
关键词
聚酯酰胺脱苄基化反应无金属催化交替共聚
Keywords
Poly(ester amide)sDebenzylationMetal-free catalysisAlternating copolymerization
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