寡肽组装体及其肿瘤光热免疫治疗应用

刘亚洲; 邢蕊蕊; 闫学海

doi:10.11777/j.issn1000-3304.2022.22221

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寡肽组装体及其肿瘤光热免疫治疗应用

专论 | 更新时间：2024-10-08

- 寡肽组装体及其肿瘤光热免疫治疗应用
- Peptide-based Assemblies and Their Application in Photothermal Immunotherapy of Cancer
- 高分子学报 2022年53卷第10期页码：1173-1186
- 作者机构：
  
  1.中国科学院过程工程研究所生化工程国家重点实验室北京 100190
  2.中国科学院大学化学工程学院北京 100049
  3.中国科学院过程工程研究所介尺度科学研究中心北京 100190
- 作者简介：
  
  [ "邢蕊蕊，女，1988年生. 中国科学院过程工程研究所生化工程国家重点实验室副研究员，硕士生导师. 分别于2012年和2017年在燕山大学获得学士及博士学位. 以第一作者或通讯作者在《Adv. Mater.》《Angew. Chem. Int. Ed.》《Coord. Chem. Rev.》等国际刊物上发表论文30余篇. 2021年入选中国科学院青年创新促进会. 主要研究方向为生物分子自组装和肿瘤光热免疫疗法，包括寡肽与生物色素自组装调控及机制研究、自组装生物纳米材料的设计、药物递送系统及新剂型的构筑、癌症诊疗应用." ]
  [ "闫学海，男，1979年生. 中国科学院过程工程研究所研究员，博士生导师. 中国科学院化学研究所获得博士学位，德国马普胶体与界面研究所从事博士后和洪堡学者研究工作. 2020年获国家自然科学基金委“杰出青年”科学基金资助，科技部“中青年科技创新领军人才”(2018年). 已发表学术论文170余篇，他引12000余次. 申请中国专利30余项(授权17项)，国际PCT专利4项. 目前担任《Colloids Surf. A》《Green Energ. Environ.》副主编. 主要研究方向为生物分子组装与工程，包括肽、蛋白质等生物分子组装与药物剂型化过程中相关技术的基础和应用研究，从分子到纳微尺度等多层次上研究结构形成与功能的内在联系，发现和揭示生物分子组装的新现象、新机制，开发功能组装体系在生物医药领域的创新性应用." ]
- 基金信息：
  
  国家自然科学基金(基金号 ┣22025207;22072154);22077122┫
- DOI：10.11777/j.issn1000-3304.2022.22221
  中图分类号：
- 纸质出版日期：2022-10-20，
  
  网络出版日期：2022-08-24，
  
  收稿日期：2022-06-03，
  
  录用日期：2022-07-18
- 稿件说明：
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刘亚洲,邢蕊蕊,闫学海.寡肽组装体及其肿瘤光热免疫治疗应用[J].高分子学报,2022,53(10):1173-1186.

Liu Ya-zhou,Xing Rui-rui,Yan Xue-hai.Peptide-based Assemblies and Their Application in Photothermal Immunotherapy of Cancer[J].ACTA POLYMERICA SINICA,2022,53(10):1173-1186.
刘亚洲,邢蕊蕊,闫学海.寡肽组装体及其肿瘤光热免疫治疗应用[J].高分子学报,2022,53(10):1173-1186. DOI： 10.11777/j.issn1000-3304.2022.22221.

Liu Ya-zhou,Xing Rui-rui,Yan Xue-hai.Peptide-based Assemblies and Their Application in Photothermal Immunotherapy of Cancer[J].ACTA POLYMERICA SINICA,2022,53(10):1173-1186. DOI： 10.11777/j.issn1000-3304.2022.22221.

摘要

光热治疗与免疫治疗功能上的互补以及协同效应使得光热免疫治疗在抑制实体瘤及转移瘤方面具有非常优异的表现，然而当前使用的光热免疫制剂的局限性限制了其临床应用转化，对于这种复合疗法的开发和优化已经成为肿瘤治疗领域的研究热点. 其中，基于寡肽分子设计的功能组装体获得了越来越多的关注，这类组装体不仅可以通过氨基酸编码设计组装结构，而且可以通过生物活性肽的引入实现优异的抗肿瘤治疗性能. 本专论中将根据寡肽分子参与抗肿瘤体系构建的不同作用，结合本团队的研究进展，对近期寡肽组装体在肿瘤光热免疫治疗的研究进行总结. 首先探讨了寡肽参与光热免疫体系组装调控的思路，阐述了组装调控过程中寡肽在强化体系稳定性、优化光热转化效率及诱导免疫应答的机理. 此外，还结合国内外研究现状，对不同功能肽在肿瘤光热免疫治疗中的作用进行了总结，并分析了寡肽组装体在肿瘤治疗领域的应用前景，最后对该领域的发展方向进行了展望.

Abstract

With the complementary and synergistic effects on anticancer function

the combined utilization of photothermal therapy and immunotherapy is one of the priority methods for eliminating solid tumor and metastatic tumor. However

the limitations of photothermal immunoagents currently in use bring drawbacks to their clinical application prospects. The development and optimization of this combined therapy have become a research hotspot in the field of cancer treatment. More and more attention has been paid to functional assemblies based on oligopeptide molecular design. Such assemblies can not only design the assembly structure through amino acid encoding

but also achieve excellent anti-tumor therapeutic performance through the introduction of bioactive peptides. In this feature article

we summarize the recent researches on oligopeptide-based assemblies for tumor photothermal immunotherapy in terms of the different roles of peptide molecules in the construction of assembly system. We first discuss the roles of oligopeptides participating in the assembly regulation of photothermal immune system

and then elaborate the mechanisms of oligopeptides in optimizing system stability

enhancing photothermal conversion efficiency

and inducing immune response in the assembly process. In addition

we also summarize the roles of different functional peptides in photothermal immunotherapy of cancer

and discuss the application prospect of oligopeptide assembly in cancer therapy.

关键词

寡肽色素超分子自组装功能组装体光热免疫疗法

Keywords

PeptideChromophoreSupramolecular self-assemblyFunctional assembliesPhotothermal immunotherapy

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