基于工程化细菌的活性生物材料研究及其医学应用

陈欢欢; 张先正

doi:10.11777/j.issn1000-3304.2022.22334

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基于工程化细菌的活性生物材料研究及其医学应用

综述 | 更新时间：2024-01-18

- 基于工程化细菌的活性生物材料研究及其医学应用
- Engineered Bacteria-based Living Biomaterials for Biomedical Applications
- 高分子学报 2023年54卷第5期页码：550-563
- 作者机构：
  
  武汉大学化学与分子科学学院生物医用高分子材料教育部重点实验室武汉 430072
- 作者简介：
  
  [ "张先正，男，1971年生. 1994、1997和2000年相继于武汉大学获学士、硕士和博士学位. 2000~2001年新加坡材料研究所博士后. 2001~2004年美国康奈尔大学博士后. 2004年至今武汉大学化学与分子科学学院高分子系教授. 长江学者特聘教授、万人计划领军人才；曾获国家杰出青年基金资助. 国际生物材料科学与工程学会联合会会士、英国皇家化学会会士. 主要研究方向是生物医用高分子及其生物医学应用." ]
- 基金信息：
  
  国家重点基础研究发展计划(2019YFA0905603);国家自然科学基金(基金号 ┣22135005;51833007);21721005┫
- DOI：10.11777/j.issn1000-3304.2022.22334
  中图分类号：
- 纸质出版日期：2023-05-20，
  
  网络出版日期：2022-12-13，
  
  收稿日期：2022-10-08，
  
  录用日期：2022-11-21
扫描看全文
陈欢欢,张先正.基于工程化细菌的活性生物材料研究及其医学应用[J].高分子学报,2023,54(05):550-563.

Chen Huan-huan,Zhang Xian-zheng.Engineered Bacteria-based Living Biomaterials for Biomedical Applications[J].ACTA POLYMERICA SINICA,2023,54(05):550-563.
陈欢欢,张先正.基于工程化细菌的活性生物材料研究及其医学应用[J].高分子学报,2023,54(05):550-563. DOI： 10.11777/j.issn1000-3304.2022.22334.

Chen Huan-huan,Zhang Xian-zheng.Engineered Bacteria-based Living Biomaterials for Biomedical Applications[J].ACTA POLYMERICA SINICA,2023,54(05):550-563. DOI： 10.11777/j.issn1000-3304.2022.22334.

摘要

细菌由于具有高度生物相容性、运动性和可自主感应生理信号，基于细菌的疗法和递送系统已经被广泛应用于医学领域，包括生物成像、疾病治疗以及组织修复与再生等. 本文从工程化细菌的构建、生物医学应用以及临床转化三方面总结和评述了生物医用工程化细菌领域的研究进展. 重点介绍了通过化学工程化策略对细菌进行改造，在维持细菌自主性和动态功能的同时赋予其新的功能，提高疾病诊断效率，改善治疗效果. 此外，还探讨了工程化的细菌在医学领域上的最新进展和应用前景，最后对工程化细菌未来在医学应用上的挑战进行了简要的展望.

Abstract

Living bacteria have the characteristics of biocompatibility

motility and can autonomously sense physiological signals

which can be used as therapeutic agents or drug carriers for the treatment of a variety of intractable diseases

including bioimaging

disease treatment

and tissue repair and regeneration. However

bacteria still have shortcomings for medical applications. For examples

some bacteria are often fragile to unfriendly environmental stimulation

leading to unnecessary bacterial death and reduced treatment effectiveness. Recently

various physicochemical and bioengineered modification strategies have been developed for individual bacteria to improve the bioavailability and efficacy

as well as achieve targeted delivery of conventional drugs. In this review

we highlight recent advance in engineered bacteria-based living biomaterials for biomedical applications in terms of engineered bacteria

biomedical application

and clinical transformation. According to the charge state

chemical groups

proteins and antigens of the bacterial surface

we systematically introduce the engineered bacteria modified with physicochemical and bioengineered strategies

especially for single bacteria. In addition

we highlight engineered bacteria-based living biomaterials for emerging diagnosis and advanced therapy

including imaging

biosensor

disease treatment

and tissue repair and regeneration

etc. Furtherly

in the clinical translation

we summarize the new progress of engineered bacteria in the treatment of tumor and gastrointestinal diseases

as well as the great success of engineered bacteria in various clinical trials. Finally

the opportunities and challenges in the future medical application of engineered bacteria have been briefly prospected. This review offers the progress in the application of engineered bacteria based on living biomaterials in biomedical application

which has potential for the development of bacterial therapy in the future.

关键词

活性生物材料工程化细菌化学修饰基因编辑医学应用

Keywords

Living biomaterialBiomedical applicationEngineered bacteriaChemical modificationGene editing

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