苯硼酸功能化聚合物纳米载体用于蛋白质药物胞内递送

陈华; 崔力允; 李圆凤; 刘勇; 马如江; 史林启

doi:10.11777/j.issn1000-3304.2022.22384

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苯硼酸功能化聚合物纳米载体用于蛋白质药物胞内递送

综述 | 更新时间：2023-03-08

- 苯硼酸功能化聚合物纳米载体用于蛋白质药物胞内递送
- Phenylboronic Acid Functionalized Polymer Nanocarriers for Intracellular Delivery of Protein Drugs
- 高分子学报 2023年54卷第4期页码：451-466
- 作者机构：
  
  1.南开大学化学学院高分子化学研究所天津 300071
  2.温州医科大学附属第一医院转化医学实验室温州 325000
  3.国科温州研究院（温州生物材料与工程研究所）温州 325001
- 作者简介：
  
  [ "刘勇，男，1987年生. 2010年于四川大学化学学院取得学士学位，2016年南开大学博士毕业，获得南开大学和荷兰格罗宁根大学双博士学位，研究领域为具有生物活性的高分子材料设计、合成及自组装及其在克服细菌/癌症耐药性方面的应用. 近5年，以第一作者或通讯作者发表SCI论文25篇，中科院分区一区论文22篇，其中影响因子大于10的文章19篇. 获江苏省“双创博士”，温州市“瓯越海智计划”人才，以及国家优秀自费留学生奖学金等." ]
  [ "马如江，男，1977年生. 2000年于天津工业大学材料科学系取得学士学位，2007年南开大学博士毕业并留校任教，2013起任南开大学化学学院副研究员；研究领域为生物医用高分子材料的合成、自组装及在胰岛素/蛋白质药物递送方面的应用；主持完成3项国家自然科学基金项目，以第一作者或通讯作者发表SCI论文29篇，其中影响因子大于10的文章6篇." ]
- 基金信息：
  
  国家自然科学基金(基金号 ┣51773099);51933006┫
- DOI：10.11777/j.issn1000-3304.2022.22384
  中图分类号：
- 纸质出版日期：2023-04-20，
  
  网络出版日期：2023-01-10，
  
  收稿日期：2022-11-11，
  
  录用日期：2022-12-21
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陈华,崔力允,李圆凤等.苯硼酸功能化聚合物纳米载体用于蛋白质药物胞内递送[J].高分子学报,2023,54(04):451-466.

Chen Hua,Cui Li-yun,Li Yuan-feng,et al.Phenylboronic Acid Functionalized Polymer Nanocarriers for Intracellular Delivery of Protein Drugs[J].ACTA POLYMERICA SINICA,2023,54(04):451-466.
陈华,崔力允,李圆凤等.苯硼酸功能化聚合物纳米载体用于蛋白质药物胞内递送[J].高分子学报,2023,54(04):451-466. DOI： 10.11777/j.issn1000-3304.2022.22384.

Chen Hua,Cui Li-yun,Li Yuan-feng,et al.Phenylboronic Acid Functionalized Polymer Nanocarriers for Intracellular Delivery of Protein Drugs[J].ACTA POLYMERICA SINICA,2023,54(04):451-466. DOI： 10.11777/j.issn1000-3304.2022.22384.

摘要

蛋白质药物在疾病治疗方面具有广泛应用，但它们的低细胞膜穿透性往往导致生物利用度较低. 近年来，人们开发了一系列纳米载体用于提高蛋白质药物的胞内递送效率，其中基于苯硼酸及其衍生物的聚合物纳米载体显示出良好的应用前景. 本文综述了苯硼酸功能化聚合物纳米载体在蛋白质药物胞内递送方面的最新研究进展. 首先，简要介绍了苯硼酸的化学性质及其二醇、pH和活性氧(ROS)响应性. 其次，从苯硼酸与蛋白质药物的结合方式不同出发，重点综述了通过动态共价作用和N→B配位等非共价作用构筑的苯硼酸功能化聚合物纳米载体在蛋白质药物胞内递送方面的典型研究实例，并对这些载体的组成、构筑方式和响应性释放机制进行了分析、总结. 最后，介绍了利用苯硼酸增强细胞摄取和促进药物透过血脑屏障方面的研究进展. 希望能为设计制备基于苯硼酸的新型蛋白质药物胞内递送体系提供借鉴.

Abstract

Protein drugs have a wide range of applications in the treatment of many diseases. However

the poor cell membrane penetration of protein drugs often leads to low bioavailability. In recent years

a series of nanocarriers have been developed to improve the efficiency of intracellular delivery of protein drugs. Among them

nanocarrier based on phenylboronic acid and its derivatives have shown good application prospects. This paper reviews the latest research progress of phenylboronic acid-functionalized polymer nanocarriers for intracellular delivery of protein drugs. Firstly

the chemical properties of phenylboronic acid and its responsiveness to diols

pH and ROS are briefly introduced. Secondly

from the perspective of different binding modes of phenylboronic acid and protein drugs

this review focuses on the typical research examples of phenylboronic acid-functionalized polymer nanocarriers constructed by dynamic covalent bonds and non-covalent interactions such as N→B coordination in the intracellular delivery of protein drugs. The compositions

construction method

and responsive release mechanism of these nanocarriers are analyzed and summarized. Finally

the research progress of phenylboronic acid in enhancing cell uptake and drug permeation through blood brain barrier is introduced. It is hoped that this paper can provide a reference for the design and preparation of novel intracellular delivery systems of protein drugs based on phenylboronic acid.

关键词

蛋白质药物胞内递送苯硼酸响应性释放纳米载体

Keywords

Protein drugsIntracellular deliveryPhenylboronic acidResponsive releaseNanocarriers

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