<italic style="font-style: italic">D</italic>-酪氨酸与多黏菌素B修饰高分子涂层的构建及其抗细菌生物被膜功能研究

殷光明; 赵娜娜; 丁小康; 徐福建

doi:10.11777/j.issn1000-3304.2023.23160

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D-酪氨酸与多黏菌素B修饰高分子涂层的构建及其抗细菌生物被膜功能研究

研究论文 | 更新时间：2024-01-03

- D-酪氨酸与多黏菌素B修饰高分子涂层的构建及其抗细菌生物被膜功能研究
- Fabrication of D-tyrosine and Polymyxin B Modified Polymer Coatings and Their Functions in Resisting Bacterial Biofilm Formation
- 高分子学报 2024年55卷第1期页码：13-26
- 作者机构：
  
  北京化工大学材料科学与工程学院北京 100029
- 作者简介：
  
  E-mail:dingxk@mail.buct.edu.cn
  E-mail:xufj@mail.buct.edu.cn;
- 基金信息：
  
  国家自然科学基金(基金号 ┣21975014;92056120);52293382, 52221006┫;北京化工大学-中日友好医院生物医学转化工程研究中心联合项目(XK2022-01)
- DOI：10.11777/j.issn1000-3304.2023.23160
  中图分类号：
- 纸质出版日期：2024-01-20，
  
  网络出版日期：2023-09-08，
  
  收稿日期：2023-06-13，
  
  录用日期：2023-07-13
- 稿件说明：
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殷光明, 赵娜娜, 丁小康, 徐福建. D-酪氨酸与多黏菌素B修饰高分子涂层的构建及其抗细菌生物被膜功能研究. 高分子学报, 2024, 55(1), 13-26

Yin, G. M.; Zhao, N. N.; Ding, X. K.; Xu, F. J. Fabrication of D-tyrosine and polymyxin B modified polymer coatings and their functions in resisting bacterial biofilm formation. Acta Polymerica Sinica, 2024, 55(1), 13-26
殷光明, 赵娜娜, 丁小康, 徐福建. D-酪氨酸与多黏菌素B修饰高分子涂层的构建及其抗细菌生物被膜功能研究. 高分子学报, 2024, 55(1), 13-26 DOI： 10.11777/j.issn1000-3304.2023.23160.

Yin, G. M.; Zhao, N. N.; Ding, X. K.; Xu, F. J. Fabrication of D-tyrosine and polymyxin B modified polymer coatings and their functions in resisting bacterial biofilm formation. Acta Polymerica Sinica, 2024, 55(1), 13-26 DOI： 10.11777/j.issn1000-3304.2023.23160.

摘要

聚氯乙烯(PVC)医用导管在使用过程中容易形成细菌生物被膜并引发细菌感染，严重威胁患者生命健康. 本研究采用酸敏感动态共价键将具有促进细菌生物被膜解散功能的

-酪氨酸、具有杀菌功能的多黏菌素B，以及具有良好生物相容性的醛化葡聚糖修饰到医用导管常用的PVC材料表面，并研究其抗细菌生物被膜形成的功能. 研究表明，修饰

-酪氨酸的高分子涂层能够有效抑制PVC表面细菌生物被膜的形成，结晶紫染色的结果表明具有多层交联高分子涂层修饰的PVC表面可以显著降低细菌生物被膜的生成(

=3，***

0.001)，形成的生物被膜仅为未修饰PVC片材表面形成生物被膜的7.2%. 该多层交联高分子涂层可有效减少植入体周围细菌感染引发的组织炎症，为构建抗细菌生物被膜医用导管提供了一种新的策略.

Abstract

Poly(vinyl chloride) (PVC) medical catheters are prone to form bacterial biofilms and result in bacterial infections during application

which pose formidable threat to public health. As the antibiotic molecules are difficult to penetrate into the biofilms to kill bacteria

there is an urgent demand in developing polymer coatings to resist the formation of bacterial biofilms. Herein

the functional molecules of

-tyrosine

which triggers the disassembly of biofilms

polymyxin B

which is able to kill bacteria

and aldehyde-modified dextran

which has good biocompatibility

are modified onto the surface of PVC

and their functions in resisting the formation of bacterial biofilms are studied. The results show that the polymer coatings modified with

-tyrosine can resist the formation of bacterial biofilms on the substrate of PVC and reduce the tissue inflammation caused by bacterial infections. This research provides a new strategy for the manufacturing of biofilm-resisting PVC catheters for medical applications.

关键词

细菌生物被膜D-酪氨酸高分子涂层抗菌导管

Keywords

Bacterial biofilmD-tyrosinePolymer coatingAntibacterial catheter

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D-酪氨酸与多黏菌素B修饰高分子涂层的构建及其抗细菌生物被膜功能研究

Fabrication of D-tyrosine and Polymyxin B Modified Polymer Coatings and Their Functions in Resisting Bacterial Biofilm Formation

DOI：10.11777/j.issn1000-3304.2023.23160

摘要

Abstract

关键词

Keywords

references