可控释放二氧化硫的高分子纳米药物

王浩; 肖春生; 陈学思

doi:10.11777/j.issn1000-3304.2023.23169

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可控释放二氧化硫的高分子纳米药物

综述 | 更新时间：2024-01-03

- 可控释放二氧化硫的高分子纳米药物
- Polymeric Nanomedicines for Controlled Release of Sulfur Dioxide
- 高分子学报 2024年55卷第1期页码：1-12
- 作者机构：
  
  中国科学院长春应用化学研究所生态环境高分子材料重点实验室长春 130022
- 作者简介：
  
  [ "肖春生，男，1985年生. 2006年毕业于中国科学技术大学，获得学士学位. 2012年毕业于中国科学院长春应用化学研究所，获得博士学位. 2012年至今，在中国科学院长春应用化学研究所工作，历任助理研究员、副研究员和研究员. 2022年获得国家自然科学基金委优秀青年科学基金项目资助，主要从事生物医用高分子材料的制备及其在肿瘤、细菌感染和炎症性疾病治疗等领域的应用研究." ]
- 基金信息：
  
  国家自然科学基金(基金号 52222307);吉林省自然科学基金(基金号 20230101129JC)
- DOI：10.11777/j.issn1000-3304.2023.23169
  中图分类号：
- 纸质出版日期：2024-01-20，
  
  网络出版日期：2023-11-21，
  
  收稿日期：2023-06-25，
  
  录用日期：2023-09-13
- 稿件说明：
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王浩, 肖春生, 陈学思. 可控释放二氧化硫的高分子纳米药物. 高分子学报, 2024, 55(1), 1-12

Wang, H.; Xiao, C. S.; Chen, X. S. Polymeric nanomedicines for controlled release of sulfur dioxide. Acta Polymerica Sinica, 2024, 55(1), 1-12
王浩, 肖春生, 陈学思. 可控释放二氧化硫的高分子纳米药物. 高分子学报, 2024, 55(1), 1-12 DOI： 10.11777/j.issn1000-3304.2023.23169.

Wang, H.; Xiao, C. S.; Chen, X. S. Polymeric nanomedicines for controlled release of sulfur dioxide. Acta Polymerica Sinica, 2024, 55(1), 1-12 DOI： 10.11777/j.issn1000-3304.2023.23169.

摘要

近年来，二氧化硫(SO

)气体分子在肿瘤治疗领域展现出巨大的潜力. 然而，传统的使用气体吸入或亚硫酸盐作为供体的方法难以应用于临床. 本综述首先介绍了一系列能够响应性释放SO

的有机小分子供体，梳理了这些小分子供体的化学结构及响应性释放方式. 接着，回顾了近年来可控释放SO

的高分子纳米药物在肿瘤治疗研究中的发展，简述了这些纳米药物的治疗机理及抗肿瘤效果. 研究表明：将SO

与高分子纳米载体技术相结合，解决了有机小分子供体存在水溶性差、肿瘤靶向性不佳等问题. 制备的可控释放SO

的高分子纳米药物能够实现在肿瘤部位的靶向富集及SO

气体的可控释放，表现出良好的抗肿瘤治疗效果. 最后，分析并指出了可控释放SO

高分子纳米药物面临的挑战，并对其未来的发展进行了展望.

Abstract

Sulfur dioxide (SO

)

previously regarded as one of industrial waste gas

has recently been identified as a novel gasotransmitter in living things. SO

could be endogenously produced from the metabolism of sulfur-containing amino acids. The endogenous SO

can regulate many biological processes

physiological and pathophysiological events. However

excessive cellular SO

would cause serious oxidative damages to DNA

proteins

and lipids

and affect the apoptosis-related gene expression in cells. This can be explained by the ability of SO

to deplete GSH and induce generation of ROS in cell. Thus

has great potential in cancer treatment. However

the traditional inhalation of SO

is not suitable for clinical use because of its unpleasant odor. Similarly

using mixed sulfites as donors of SO

also cannot meet clinical needs due to their rapid excretion from body. To address these issues

a series of stimuli-responsive SO

-releasing small-molecule donors have been developed for controlled release of SO

. Most of these small-molecule SO

donors exhibit controlled release behaviors and show great potency for therapeutic application. However

the poor water solubility and lack of tumor-targeting ability significantly hamper the clinical translation of these small-molecule SO

donors. Very recently

polymeric nanomedicines with controlled SO

-releasing ability have been developed through directly conjugating SO

-releasing donors onto the side chains of polymer or loading the SO

-releasing donors inside the polymeric nanocarriers. The resultant polymeric nanomedicines can achieve improved accumulation and targeted release of SO

in tumor sites

leading to enhanced anti-cancer efficacy and ameliorated side effect. All in all

our review firstly summarizes the chemical structure and release mechanisms of small-molecule SO

donors

and subsequently

the research progress of SO

-releasing polymeric nanomedicines is highlighted. Finally

the challenges and future perspectives on the development of SO

-releasing polymeric nanomedicines are briefly discussed.

关键词

二氧化硫高分子纳米药物药物载体肿瘤治疗气体治疗

Keywords

Sulfur dioxidePolymeric nanomedicinesDrug carrierTumor treatmentGas therapy

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