聚硫辛酸基多功能水凝胶的构建及在感染皮肤伤口修复中的应用

杜佳强; 张彦峰; 成一龙

doi:10.11777/j.issn1000-3304.2024.24006

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聚硫辛酸基多功能水凝胶的构建及在感染皮肤伤口修复中的应用

研究论文 | 更新时间：2024-09-20

- 聚硫辛酸基多功能水凝胶的构建及在感染皮肤伤口修复中的应用
- Construction of Poly(lipoic acid)-based Functional Hydrogels for Infected Skin Wound Healing
- 高分子学报 2024年55卷第5期页码：624-636
- 作者机构：
  
  西安交通大学化学学院西安 710049
- 作者简介：
  
  E-mail: yilongcheng@mail.xjtu.edu.cn
- 基金信息：
  
  国家自然科学基金(基金号 52322309);国家重点研发计划(2023YFB3810400);西安交通大学青年拔尖人才支持计划
- DOI：10.11777/j.issn1000-3304.2024.24006
  中图分类号：
- 纸质出版日期：2024-05-20，
  
  网络出版日期：2024-03-18，
  
  收稿日期：2024-01-10，
  
  录用日期：2024-01-31
- 稿件说明：
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杜佳强, 张彦峰, 成一龙. 聚硫辛酸基多功能水凝胶的构建及在感染皮肤伤口修复中的应用. 高分子学报, 2024, 55(5), 624-636

Du, J. Q.; Zhang, Y. F.; Cheng, Y. L. Construction of poly(lipoic acid)‍-based functional hydrogels for infected skin wound healing. Acta Polymerica Sinica, 2024, 55(5), 624-636
杜佳强, 张彦峰, 成一龙. 聚硫辛酸基多功能水凝胶的构建及在感染皮肤伤口修复中的应用. 高分子学报, 2024, 55(5), 624-636 DOI： 10.11777/j.issn1000-3304.2024.24006.

Du, J. Q.; Zhang, Y. F.; Cheng, Y. L. Construction of poly(lipoic acid)‍-based functional hydrogels for infected skin wound healing. Acta Polymerica Sinica, 2024, 55(5), 624-636 DOI： 10.11777/j.issn1000-3304.2024.24006.

摘要

以

-硫辛酸(LA)为单体，借助其强还原性与浓度和温度诱导开环聚合，一步法制备了负载纳米银(AgNPs)的氢键交联高分子水凝胶，并对其可注射性、自修复性、粘接能力、光热效应、抗氧化能力以及生物相容性进行了详细地研究. 在细菌感染的大鼠全层皮肤损伤模型中，该高分子水凝胶敷料可以通过光热效应杀死细菌，同时有效降低伤口处的活性氧(ROS)水平，进而调控组织损伤的炎症反应，促进感染伤口的加速愈合.

Abstract

Poly(lipoic acid)‍-based functional hydrogels incorporated with silver nanoparticles (AgNPs) are developed for bacteria-infected skin wound healing in this work. Owing to the reducibility of

α‍

-lipoic acid (LA)

AgNO

can be converted into AgNPs in the local hydrogel network (PLAS@AgNPs hydrogels)

which are synthesized by concentration- and thermo-induced ring-opening polymerization of LA in the presence of NaHCO

. Benefiting from the dynamic nature of hydrogen bonds formed by －COOH groups

PLAS@AgNPs hydrogels feature facile injectability and self-healing ability

and exhibit stable adhesion behavior with porcine skin tissues (36 kPa). The resulting hydrogels show promising photothermal efficiency due to the

in situ

formation of AgNPs

and the temperature of the hydrogels can be elevated by 38

C with the irradiation of near-infrared (NIR) light for 10 min

which can effectively inhibit the proliferation of

escherichia coli

and

staphylococcus aureus

. Moreover

the PLAS@AgNPs hydrogels can also clear the intracellular reactive oxygen species (ROS) inherited from the antioxidant nature of

LA. In a rat full-thickness skin injury model with bacterial infection

the PLAS@AgNPs hydrogel dressing can accelerate the skin wound healing with the assistance of NIR light irradiation through the synergistic effect of anti-bacteria and ROS scavenging.

关键词

水凝胶氢键硫辛酸光热效应皮肤损伤修复

Keywords

HydrogelHydrogen bondα-Lipoic acidPhotothermal effectSkin wound healing

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