基于直接电子转移的柔性纤维葡萄糖传感器

李金妍; 唐成强; 李雯君; 黄滔; 孙雪梅; 彭慧胜

doi:10.11777/j.issn1000-3304.2024.24010

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基于直接电子转移的柔性纤维葡萄糖传感器

研究论文 | 更新时间：2024-09-25

- 基于直接电子转移的柔性纤维葡萄糖传感器
- Flexible Fiber Glucose Sensor Based on Direct Electron Transfer
- 高分子学报 2024年55卷第7期页码：872-880
- 作者机构：
  
  聚合物分子工程国家重点实验室复旦大学高分子科学系纤维电子材料与器件研究院先进材料实验室上海 200438
- 作者简介：
  
  E-mail: sunxm@fudan.edu.cn
- 基金信息：
  
  国家自然科学基金(基金号 ┣52122310;22075050);T2321003┫
- DOI：10.11777/j.issn1000-3304.2024.24010
  中图分类号：
- 纸质出版日期：2024-07-20，
  
  网络出版日期：2024-04-10，
  
  收稿日期：2024-01-13，
  
  录用日期：2024-02-19
- 稿件说明：
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李金妍, 唐成强, 李雯君, 黄滔, 孙雪梅, 彭慧胜. 基于直接电子转移的柔性纤维葡萄糖传感器. 2024, 55(7), 872-880

Li, J. Y.; Tang, C. Q.; Li, W. J.; Huang, T.; Sun, X. M.; Peng, H. S. Flexible fiber glucose sensor based on direct electron transfer. Acta Polymerica Sinica, 2024, 55(7), 872-880
李金妍, 唐成强, 李雯君, 黄滔, 孙雪梅, 彭慧胜. 基于直接电子转移的柔性纤维葡萄糖传感器. 2024, 55(7), 872-880 DOI： 10.11777/j.issn1000-3304.2024.24010.

Li, J. Y.; Tang, C. Q.; Li, W. J.; Huang, T.; Sun, X. M.; Peng, H. S. Flexible fiber glucose sensor based on direct electron transfer. Acta Polymerica Sinica, 2024, 55(7), 872-880 DOI： 10.11777/j.issn1000-3304.2024.24010.

摘要

酶基电化学葡萄糖传感器具有优异的选择性和灵敏度，基于直接电子转移原理的第三代传感器有望解决第一、二代传感器所面临的易受氧气浓度干扰、电子介体不稳定等问题. 因此，本研究基于聚3

4-乙烯二氧噻吩:聚苯乙烯磺酸盐(PEDOT:PSS)和葡萄糖脱氢酶(GDH)双组分开发了柔性纤维第三代葡萄糖传感器. 该纤维传感器在10~500 μmol/L范围内具有良好的线性(

=0.9968)，灵敏度可达62.53 μA/(mmol·L

-1

·cm

)，且不受氧气影响. 纤维传感器还具有良好的柔性和可编织性，将其集成到织物中，实现了人在运动时汗液中葡萄糖的连续实时监测，为制备满足可穿戴需求的第三代葡萄糖传感器提供了新思路.

Abstract

Real-time monitor

ing of glucose concentration

in vivo

holds significant importance for disease diagnosis and treatment. The enzyme-based electrochemical glucose sensor has garnered considerable attention in the realm of real-time glucose monitoring due to its outstanding selectivity and sensitivity. Despite the development of first and second generation electrochemical glucose sensors

they encounter numerous challenges derived from their sensing principles

including interference from oxygen concentration

instability of electronic mediators

and leaching toxicity. The third generation of glucose sensor based on direct electron transfer between enzyme and electrode is anticipated to address these challenges. Here

we report an all-polymer-based flexible fiber glucose sensor (FGS) based on direct electron transfer

leveraging poly(3

‍4-vinyldioxythiophene):‍polystyrene sulfonate (PEDOT:PSS) and glucose dehydrogenase (GDH) as its constituents. The FGS exhibits commendable linearity (

=0.9968) within the range of 10-500 μmol/L and demonstrates a sensitivity of 62.53 μA/(mmol·L

-1

·cm

). The FGS is seamlessly integrated into fabric

enabling continuous real-time monitoring of glucose levels in human sweat during exercise. This work presents a novel approach for developing the third-generation glucose sensors to cater to the requirements of wearable technology.

关键词

柔性纤维葡萄糖传感器直接电子转移汗液监测聚34-乙烯二氧噻吩:聚苯乙烯磺酸盐

Keywords

Flexible fiberGlucose sensorDirect electron transferSweat monitoringPoly(34-vinyldioxythiophene):polystyrene sulfonate

references

Chen C.; Xie Q. J.; Yang D. W.; Xiao H. L.; Fu Y. C.; Tan Y. M.; Yao S. Z. Recent advances in electrochemical glucose biosensors: a review. RSC Adv., 2013, 3(14), 4473-4491. doi:10.1039/c2ra22351ahttp://dx.doi.org/10.1039/c2ra22351a

Teymourian H.; Barfidokht A.; Wang J. Electrochemical glucose sensors in diabetes management: an updated review (2010-2020). Chem. Soc. Rev., 2020, 49(21), 7671-7709. doi:10.1039/d0cs00304bhttp://dx.doi.org/10.1039/d0cs00304b

Dey R. S.; Raj C. R. Redox-functionalized graphene oxide architecture for the development of amperometric biosensing platform. ACS Appl. Mater. Interfaces, 2013, 5(11), 4791-4798. doi:10.1021/am400280uhttp://dx.doi.org/10.1021/am400280u

Degani Y.; Heller A. Direct electrical communication between chemically modified enzymes and metal electrodes. I. Electron transfer from glucose oxidase to metal electrodes via electron relays, bound covalently to the enzyme. J. Phys. Chem., 1987, 91(6), 1285-1289. doi:10.1021/j100290a001http://dx.doi.org/10.1021/j100290a001

Wooten M.; Karra S.; Zhang M. G.; Gorski W. On the direct electron transfer, sensing, and enzyme activity in the glucose oxidase/carbon nanotubes system. Anal. Chem., 2014, 86(1), 752-757. doi:10.1021/ac403250whttp://dx.doi.org/10.1021/ac403250w

Bartlett P. N.; Al-Lolage F. A. There is no evidence to support literature claims of direct electron transfer (DET) for native glucose oxidase (GOx) at carbon nanotubes or graphene. J. Electroanal. Chem., 2018, 819, 26-37. doi:10.1016/j.jelechem.2017.06.021http://dx.doi.org/10.1016/j.jelechem.2017.06.021

Blazek T.; Gorski, W. Oxidases, carbon nanotubes, and direct electron transfer: a cautionary tale. Biosens. Bioelectron., 2020, 163, 112260. doi:10.1016/j.bios.2020.112260http://dx.doi.org/10.1016/j.bios.2020.112260

Holland J. T.; Lau C.; Brozik S.; Atanassov P.; Banta S. Engineering of glucose oxidase for direct electron transfer via site-specific gold nanoparticle conjugation. J. Am. Chem. Soc., 2011, 133(48), 19262-19265. doi:10.1021/ja2071237http://dx.doi.org/10.1021/ja2071237

Bai Y. F.; Xu T. B.; Luong J. H. T.; Cui H. F. Direct electron transfer of glucose oxidase-boron doped diamond interface: a new solution for a classical problem. Anal. Chem., 2014, 86(10), 4910-4918. doi:10.1021/ac501143ehttp://dx.doi.org/10.1021/ac501143e

Zeng X. P.; Zhang Y. Z.; Du X. L.; Li Y. F.; Tang W. W. A highly sensitive glucose sensor based on a gold nanoparticles/polyaniline/multi-walled carbon nanotubes composite modified glassy carbon electrode. New J. Chem., 2018, 42(14), 11944-11953. doi:10.1039/c7nj04327ahttp://dx.doi.org/10.1039/c7nj04327a

Jeon W. Y.; Kim H. S.; Jang H. W.; Lee Y. S.; Shin U. S.; Kim H. H.; Choi Y. B. A stable glucose sensor with direct electron transfer, based on glucose dehydrogenase and chitosan hydro bonded multi-walled carbon nanotubes. Biochem. Eng. J., 2022, 187, 108589. doi:10.1016/j.bej.2022.108589http://dx.doi.org/10.1016/j.bej.2022.108589

Lin M. H.; Gupta S.; Chang C.; Lee C. Y.; Tai N. H. Carbon nanotubes/polyethylenimine/glucose oxidase as a non-invasive electrochemical biosensor performs high sensitivity for detecting glucose in saliva. Microchem. J., 2022, 180, 107547. doi:10.1016/j.microc.2022.107547http://dx.doi.org/10.1016/j.microc.2022.107547

Lu B. Y.; Yuk H.; Lin S. T.; Jian N. N.; Qu K.; Xu J. K.; Zhao X. H. Pure PEDOT:PSS hydrogels. Nat. Commun., 2019, 10(1), 1043. doi:10.1038/s41467-019-09003-5http://dx.doi.org/10.1038/s41467-019-09003-5

Ferri S.; Kojima K.; Sode K. Review of glucose oxidases and glucose dehydrogenases: a bird's eye view of glucose sensing enzymes. J. Diabetes Sci. Technol., 2011, 5(5), 1068-1076. doi:10.1177/193229681100500507http://dx.doi.org/10.1177/193229681100500507

Yoshida H.; Sakai G.; Mori K.; Kojima K.; Kamitori S.; Sode K. Structural analysis of fungus-derived FAD glucose dehydrogenase. Sci. Rep., 2015, 5, 13498. doi:10.1038/srep13498http://dx.doi.org/10.1038/srep13498

Sygmund C.; Klausberger M.; Felice A. K.; Ludwig R. Reduction of quinones and phenoxy radicals by extracellular glucose dehydrogenase from Glomerella Cingulata suggests a role in plant pathogenicity. Microbiology, 2011, 157(Pt 11), 3203-3212. doi:10.1099/mic.0.051904-0http://dx.doi.org/10.1099/mic.0.051904-0

Muguruma H.; Iwasa H.; Hidaka H.; Hiratsuka A.; Uzawa H. Mediatorless direct electron transfer between flavin adenine dinucleotide-dependent glucose dehydrogenase and single-walled carbon nanotubes. ACS Catal., 2017, 7(1), 725-734. doi:10.1021/acscatal.6b02470http://dx.doi.org/10.1021/acscatal.6b02470

Wang L. Y.; Xie S. L.; Wang Z. Y.; Liu F.; Yang Y. F.; Tang C. Q.; Wu X. Y.; Liu P.; Li Y. J.; Saiyin H.; Zheng S.; Sun X. M.; Xu F.; Yu H. B.; Peng H. S. Functionalized helical fibre bundles of carbon nanotubes as electrochemical sensors for long-term in vivo monitoring of multiple disease biomarkers. Nat. Biomed. Eng., 2020, 4(2), 159-171. doi:10.1038/s41551-019-0462-8http://dx.doi.org/10.1038/s41551-019-0462-8

Fang Y.; Feng J. Y.; Shi X.; Yang Y. Q.; Wang J. J.; Sun X.; Li W. J.; Sun X. M.; Peng H. S. Coaxial fiber organic electrochemical transistor with high transconductance. Nano Res., 2023, 16(9), 11885-11892. doi:10.1007/s12274-023-5722-yhttp://dx.doi.org/10.1007/s12274-023-5722-y

Feng J. Y.; Fang Y.; Wang C.; Chen C. R.; Tang C. Q.; Guo Y.; Wang L. Y.; Yang Y. Q.; Zhang K. L.; Wang J. J.; Chen J. W.; Sun X. M.; Peng H. S. All-polymer fiber organic electrochemical transistor for chronic chemical detection in the brain. Adv. Funct. Mater., 2023, 33(30), 2214945. doi:10.1002/adfm.202214945http://dx.doi.org/10.1002/adfm.202214945

郭悦, 王佳佳, 王立媛, 孙雪梅, 彭慧胜. 柔性纤维生物电子复合材料与器件. 高分子学报, 2022, 53(7), 707-721. doi:10.11777/j.issn1000-3304.2022.22051http://dx.doi.org/10.11777/j.issn1000-3304.2022.22051

Wang L.; Wang L. Y.; Zhang Y.; Pan J.; Li S. Y.; Sun X. M.; Zhang B.; Peng H. S. Weaving sensing fibers into electrochemical fabric for real-time health monitoring. Adv. Funct. Mater., 2018, 28(42), 1804456. doi:10.1002/adfm.201804456http://dx.doi.org/10.1002/adfm.201804456

Moyer J.; Wilson D.; Finkelshtein I.; Wong B.; Potts R. Correlation between sweat glucose and blood glucose in subjects with diabetes. Diabetes Technol. Ther., 2012, 14(5), 398-402. doi:10.1089/dia.2011.0262http://dx.doi.org/10.1089/dia.2011.0262

Bandodkar A. J.; Jia W. Z.; Yardımcı C.; Wang X.; Ramirez J.; Wang J. Tattoo-based noninvasive glucose monitoring: a proof-of-concept study. Anal. Chem., 2015, 87(1), 394-398. doi:10.1021/ac504300nhttp://dx.doi.org/10.1021/ac504300n

Zafar H.; Channa A.; Jeoti V.; Stojanović G. M. Comprehensive review on wearable sweat-glucose sensors for continuous glucose monitoring. Sensors, 2022, 22(2), 638. doi:10.3390/s22020638http://dx.doi.org/10.3390/s22020638

Toi P. T.; Trung T. Q.; Dang T. M. L.; Bae C. W.; Lee N. E. Highly electrocatalytic, durable, and stretchable nanohybrid fiber for on-body sweat glucose detection. ACS Appl. Mater. Interfaces, 2019, 11(11), 10707-10717. doi:10.1021/acsami.8b20583http://dx.doi.org/10.1021/acsami.8b20583

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