亲疏水一体化策略构筑<italic style="font-style: italic">π</italic>共轭光诊疗纳米材料的研究进展

侯胜鑫; 曲松楠; 田雷蕾

doi:10.11777/j.issn1000-3304.2024.24170

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亲疏水一体化策略构筑π共轭光诊疗纳米材料的研究进展

综述 | 更新时间：2025-01-10

- 亲疏水一体化策略构筑π共轭光诊疗纳米材料的研究进展
- The Research Progress on One-component Photodiagnostic Nanomaterials Based on π-Conjugated Amphiphilic Polymers
- 高分子学报 2024年55卷第12期页码：1622-1647
- 作者机构：
  
  1.澳门大学应用物理及材料工程研究院澳门特别行政区 999067
  2.南方科技大学材料科学与工程系深圳 518055
- 作者简介：
  
  [ "曲松楠，男，1981年生. 获得首批国家自然基金委优秀青年基金(港澳)资助. 2004和2009年于吉林大学材料科学与工程学院获学士和博士学位. 2009年进入中国科学院长春光学精密机械与物理研究所，发光学及应用国家重点实验室工作，2015年破格晋升为研究员，博士生导师. 2019年入职澳门大学应用物理及材料工程研究所，教授. 主要从事“碳纳米点发光及应用”研究，目前主要研究兴趣：(1)碳纳米点带隙可控的高效发光；(2)碳纳米点固态发光器件；(3)碳纳米点在生物成像及癌症诊疗中的应用." ]
  [ "田雷蕾，女，1980年生. 2003、2008年分获吉林大学学士、博士学位；2008~2010年在南卡莱罗纳大学和克莱姆森大学从事博士后研究；2011~2014年在芝加哥大学从事博士后；2015年入职南方科技大学材料科学与工程系，任长聘研究员、课题组长. 深圳市孔雀计划B类人才，深圳市孔雀团队核心成员，获深圳市自然科学奖二等奖. 致力于开发新型π共轭生物材料，根据分子间作用力的特点进行π共轭材料多功能诊疗应用设计，解决这类材料在分子修饰、功能复合和聚集态调控方面的问题，将π共轭材料的高效光转换性质更好地应用于生物成像和检测、光-基因联合治疗以及一体化光诊疗方向." ]
- 基金信息：
  
  国家自然科学基金(基金号 51973089);深圳市基础研究计划(基金号 JCYJ20220530113612027);南方科技大学高水平专项资金(基金号 G03050K003)
- DOI：10.11777/j.issn1000-3304.2024.24170
  中图分类号：
- CSTR：32057.14.GFZXB.2024.7280
- 纸质出版日期：2024-12-20，
  
  网络出版日期：2024-10-21，
  
  收稿日期：2024-06-16，
  
  录用日期：2024-07-12
- 稿件说明：
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侯胜鑫, 曲松楠, 田雷蕾.亲疏水一体化策略构筑π共轭光诊疗纳米材料的研究进展.高分子学报, 2024, 55(12), 1622-1647

Hou, S. X.; Qu, S. N.; Tian, L. L. The research progress on one-component photodiagnostic nanomaterials based on π-conjugated amphiphilic polymers. Acta Polymerica Sinica, 2024, 55(12), 1622-1647
侯胜鑫, 曲松楠, 田雷蕾.亲疏水一体化策略构筑π共轭光诊疗纳米材料的研究进展.高分子学报, 2024, 55(12), 1622-1647 DOI： 10.11777/j.issn1000-3304.2024.24170. CSTR： 32057.14.GFZXB.2024.7280.

Hou, S. X.; Qu, S. N.; Tian, L. L. The research progress on one-component photodiagnostic nanomaterials based on π-conjugated amphiphilic polymers. Acta Polymerica Sinica, 2024, 55(12), 1622-1647 DOI： 10.11777/j.issn1000-3304.2024.24170. CSTR： 32057.14.GFZXB.2024.7280.

摘要

有机光诊疗

共轭分子由于明确的分子结构、丰富的激发态性质、大的摩尔吸光系数以及优异的生物安全性，在生物成像和肿瘤治疗方面展示出巨大的应用潜力. 然而，

共轭分子的强疏水性严重制约了它在生物体内的实际应用. 目前的研究致力于利用两亲性的聚合物载体包裹疏水分子以达到在水中分散的目的，这可能会导致不可控的分子泄露并造成严重的肝脾富集. 合成

共轭双亲聚合物构建一体化胶束是增强生物安全性，实现体内光诊疗应用的理想手段. 本文首先介绍了光诊疗

共轭分子的种类和分子结构设计，及其光物理化学性质. 其次，详细探讨了一体化胶束的构建方法，主要包括聚合物直接接枝(graft to)和

共轭分子参与聚合(graft from) 2种方式. 同时，对一体化胶束构建过程中使用亲水性高分子种类及功能进行了分类探讨，主要包括非生物大分子聚乙二醇和聚两性离子以及生物大分子核酸、多肽、多糖等. 最后，讨论了一体化胶束的独特性质及其在调控分子组装结构、调节生物体代谢性质、细胞和活体成像以及肿瘤治疗等方面的应用. 并对一体化的有机光诊疗纳米胶束在生物医学领域的研究进展进行了总结和展望.

Abstract

Organic phototheranostic

‍-conjugated molecules exhibit great potential for bioimaging and tumor therapy applications due to their well-defined molecular structures

abundant excited state properties

large molar absorption coefficients

and excellent biosafety. However

the strong hydrophobicity of

‍-conjugated molecules severely restricts their practical applications in organisms. Current research is devoted to using amphiphilic polymer carriers to encapsulate hydrophobic

‍-conjugated molecules for water dispersion. This may lead to uncontrollable molecular leakage and cause severe liver and spleen enrichment. Synthesis of

‍-conjugated amphiphilic polymers and construction of one-component micelles have become an emerging strategy for developing phototheranostic materials. In this review

we summarized the recent research progress on one-component phototheranostic nanomaterials based on

‍-conjugated amphiphilic polymers. First

the category of phototheranostic

‍-conjugated molecules is introduced. Secondly

the constructions of one-component micelles are discussed in detail. The synthesis of

‍-conjugated amphiphilic polymers mainly includes the "graft to" and "graft from" methods. Also

the hydrophilic polymers for the synthesis of

‍-conjugated amphiphilic polymers are classified and discussed

mainly including synthetic polymers

such as polyethylene glycol and zwitterionic polymer

and biological macromolecules

like nucleic acids

peptides

polysaccharides and so on. Finally

the unique properties of these one-component

‍-conjugated nanomaterials and their applications in regulating molecular assembly

enhancing biocompatible properties

cellular a

nd clinical imaging

and tumor therapy are reviewed.

关键词

光诊疗π共轭分子水溶性高分子一体化胶束

Keywords

Phototheranosticsπ‍-Conjugated moleculesWater-soluble polymerOne-component micelles

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亲疏水一体化策略构筑π共轭光诊疗纳米材料的研究进展

The Research Progress on One-component Photodiagnostic Nanomaterials Based on π-Conjugated Amphiphilic Polymers

DOI：10.11777/j.issn1000-3304.2024.24170

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