光点击化学交联制备软组织工程用四臂聚己内酯支架及其性能研究

项玉珍; 陈思; 王旭

doi:10.11777/j.issn1000-3304.2025.24303

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光点击化学交联制备软组织工程用四臂聚己内酯支架及其性能研究

研究论文 | 更新时间：2025-07-08

- 光点击化学交联制备软组织工程用四臂聚己内酯支架及其性能研究
- Preparation and Properties of Four-arm Polycaprolactone Scaffolds for Soft Tissue Engineering by Photo-click Chemical Cross-linking
- 高分子学报 2025年56卷第7期页码：1159-1169
- 作者机构：
  
  浙江工业大学材料科学与工程学院湖州 313299
- 作者简介：
  
  E-mail: chensi@zjut.edu.cn
  wangxu@zjut.edu.cn
- 基金信息：
  
  国家自然科学基金(基金号 ┣52273094;52003237);21875009┫;浙江省“尖兵”“领雁”研发攻关计划(2023C01083)
- DOI：10.11777/j.issn1000-3304.2025.24303
  中图分类号：
- CSTR：32057.14.GFZXB.2025.7385
- 收稿日期：2024-12-23，
  
  录用日期：2025-03-25，
  
  网络出版日期：2025-05-14，
  
  纸质出版日期：2025-07-20
- 稿件说明：
移动端阅览
项玉珍, 陈思, 王旭. 光点击化学交联制备软组织工程用四臂聚己内酯支架及其性能研究. 高分子学报, 2025, 56(7), 1159-1169

Xiang, Y. Z.; Chen, S.; Wang, X. Preparation and properties of four-arm polycaprolactone scaffolds for soft tissue engineering by photo-click chemical cross-linking. Acta Polymerica Sinica, 2025, 56(7), 1159-1169
项玉珍, 陈思, 王旭. 光点击化学交联制备软组织工程用四臂聚己内酯支架及其性能研究. 高分子学报, 2025, 56(7), 1159-1169 DOI： 10.11777/j.issn1000-3304.2025.24303. CSTR： 32057.14.GFZXB.2025.7385.

Xiang, Y. Z.; Chen, S.; Wang, X. Preparation and properties of four-arm polycaprolactone scaffolds for soft tissue engineering by photo-click chemical cross-linking. Acta Polymerica Sinica, 2025, 56(7), 1159-1169 DOI： 10.11777/j.issn1000-3304.2025.24303. CSTR： 32057.14.GFZXB.2025.7385.

摘要

针对传统聚己内酯(PCL)材料刚性较高及数字光处理(DLP)技术光敏树脂种类有限的问题，开发了一种基于炔基封端四臂聚己内酯(4sPCL)-季戊四醇四(巯基乙酸)酯(PETMA)光点击化学交联体系的新型DLP兼容光敏树脂. 通过调控4sPCL分子量及添加浓度，系统研究了支架的光固化均匀性、机械性能与热行为. 实验表明，当采用

=5000 g/mol的4sPCL、添加量为10 wt%时，所制备的支架兼具与软组织匹配的压缩强度((86.1±8.1) kPa)、快速光固化特性(20~25 s)及优异形状恢复性. 本研究为构建兼具精密结构调控与仿生力学性能的软组织工程支架提供了创新解决方案.

Abstract

In this study

a new DLP-compatible photosensitive resin based on the alkyne-capped four-arm polycaprolactone (4sPCL)‍-pentaerythritol tetrakis(mercaptoacetic acid) ester (PETMA) photoclick chemical cross-linking system was developed in response to the problems of the high rigidity of the traditional polycaprolactone (PCL) materials and the limited variety of photosensitive resins for digital light processing (DLP) technology. The light-curing uniformity

mechanical properties and thermal behavior of the scaffolds were systematically investigated by regulat

ing the molecular weight and addition concentration of 4sPCL. The experiments showed that when

=5000 g/mol and 10 wt% of 4sPCL were used

the prepared scaffolds possessed soft-tissue-matched compressive strength ((86.1±8.1) kPa)

fast light-curing properties (20-25 s) and excellent shape recovery. This study provides an innovative solution for the construction of soft tissue engineering scaffolds with precise structural modulation and biomimetic mechanical properties.

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