全血灌流用含功能基团超交联吸附剂的制备与性能研究

邵柯; 彭新艳; 刘云鸿; 韦跃兰; 陈凯文; 周翔

doi:10.11777/j.issn1000-3304.2025.25080

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全血灌流用含功能基团超交联吸附剂的制备与性能研究

研究论文 | 更新时间：2025-08-05

- 全血灌流用含功能基团超交联吸附剂的制备与性能研究
- Preparation and Performance Study of Hypercrosslinked Adsorbents with Functional Groups for Whole Blood Hemoperfusion
- 高分子学报 2025年页码：1-16
- 作者机构：
  
  1.泉州师范学院化工与材料学院福建泉州 362000
  2.健帆生物科技集团股份有限公司广东珠海 519085
  3.广州职业技术大学珠宝学院广东广州 510640
- 作者简介：
  
  E-mail: pengxinyan@qztc.edu.cn
  liuyunhong@qztc.edu.cn
- 基金信息：
  
  国家自然科学基金青年科学基金(基金号 82100793);福建省自然科学基金(基金号 ┣2020J05152);2020J05153┫
- DOI：10.11777/j.issn1000-3304.2025.25080
  中图分类号：
- CSTR：32057.14.GFZXB.2025.7445
- 收稿日期：2025-03-25，
  
  录用日期：2025-06-27，
  
  网络出版日期：2025-08-04，
- 稿件说明：
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邵柯, 彭新艳, 刘云鸿, 韦跃兰, 陈凯文, 周翔. 全血灌流用含功能基团超交联吸附剂的制备与性能研究. 高分子学报, doi: 10.11777/j.issn1000-3304.2025.25080

Shao, K.; Peng, X. Y.; Liu, Y. H.; Wei, Y. L.; Chen, K. W.; Zhou, X. Preparation and performance study of hypercrosslinked adsorbents with functional groups for whole blood hemoperfusion. Acta Polymerica Sinica, doi: 10.11777/j.issn1000-3304.2025.25080
邵柯, 彭新艳, 刘云鸿, 韦跃兰, 陈凯文, 周翔. 全血灌流用含功能基团超交联吸附剂的制备与性能研究. 高分子学报, doi: 10.11777/j.issn1000-3304.2025.25080 DOI： CSTR： 32057.14.GFZXB.2025.7445.

Shao, K.; Peng, X. Y.; Liu, Y. H.; Wei, Y. L.; Chen, K. W.; Zhou, X. Preparation and performance study of hypercrosslinked adsorbents with functional groups for whole blood hemoperfusion. Acta Polymerica Sinica, doi: 10.11777/j.issn1000-3304.2025.25080 DOI： CSTR： 32057.14.GFZXB.2025.7445.

摘要

在临床尿毒症血液灌流治疗领域，超交联聚苯乙烯吸附剂已得到了广泛的应用，但仍面临着材料制备和改性过程繁琐复杂、以及对蛋白结合类毒素(PBUTs)吸附清除能力不足的问题. 为解决上述问题，本研究采用一步法外交联改性制备技术，利用带有特定功能基团的小分子外交联剂，如(二甲氨基)乙醛缩二甲醇(DDA)和氨基乙醛缩二甲醇(DMEA)，对一次交联聚苯乙烯树脂PDVB进行同步后交联和改性，成功制备出功能化超交联聚苯乙烯吸附剂HCP-DMEA和HCP-DDA. 利用红外光谱、光电子能谱、扫描电镜及BET等技术手段，对超交联树脂的物理化学结构进行了系统表征. 研究结果表明，含功能基团小分子外交联剂可对一次交联树脂同时实现后交联反应和基团改性，成功在吸附剂结构中引入不同含氮基团；所制备的

HCP-DMEA和HCP-DDA树脂同时具有较好的尿毒症蛋白结合类毒素(IS，pCS)和中大分子毒素(

2-MG，IL-6)吸附性能. 与商用HA130树脂相似，本研究制备的超交联树脂具有较好的血液相容性，有望在全血灌流、人工肾等领域广泛应用，为尿毒症患者提供更高效、更安全的治疗选择.

Abstract

In the field of clinical uremic blood perfusion therapy

hypercrosslinked polystyrene adsorbents have been widely applied. However

they still face challenges

including the complexity of material preparation and modification processes

as well as insufficient adsorption capabilities for protein-bound uremic toxins (PBUTs). To address the aforementioned issues

this study employs a one-step external crosslinking modification technique

utilizing small-molecule external crosslinkers with specific functional groups

such as (dimethylamino)acetaldehyde dimethyl acetal (DDA) and aminoacetaldehyde dimethyl acetal (DMEA)

to simultaneously perform post-crosslinking and modification on the pre-crosslinked polystyrene resin PDVB. This process successfully produced functionalized hyper-crosslinked polystyrene adsorbents HCP-DMEA and HCP-DDA. The physicochemical structures of the hypercrosslinked resins were characterized and analyzed using techniq

ues such as Fourier infrared spectroscopy (FTIR)

X-ray photoelectron spectroscopy (XPS)

scanning electron microscopy (SEM)

and Brunauer-Emmett-Teller (BET) surface area analysis. The research results indicated that small-molecule external crosslinkers containing functional groups could simultaneously achieve post-crosslinking reactions and group modifications on the pre-crosslinked resin

successfully introducing different nitrogen-containing groups into the adsorbent structure. The prepared HCP-DMEA and HCP-DDA resins exhibited excellent adsorption performance for both PBUTs (IS

pCS) and middle-to-large molecular toxins (

2-MG

IL-6). Similar to the commercial HA130 resin

these hypercrosslinked resins demonstrated good blood compatibility and holded promising potential for wide application in whole blood hemoperfusion

artificial kidneys

and related fields. It is expected to provide more efficient and safer treatment options for patients with uremia.

关键词

Keywords

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