Kappa卡拉胶复合凝胶微针敷料的设计及感染创面应用

陈彩怡; 王頔; 李俊杰; 张彤; 李乐凡; 侯婷婷; 廖禄生; 王飞; 李程鹏

doi:10.11777/j.issn1000-3304.2025.25126

您当前的位置：

首页 >

文章列表页 >

Kappa卡拉胶复合凝胶微针敷料的设计及感染创面应用

研究论文 | 更新时间：2026-02-09

- Kappa卡拉胶复合凝胶微针敷料的设计及感染创面应用
- Design of Kappa Carrageenan Composite Gel Microneedle Dressing and Application to Infected Wounds
- 高分子学报 2026年57卷第2期页码：502-521
- 作者机构：
  
  1.广东海洋大学化学与环境学院湛江 524088
  2.中国热带农业科学院农产品加工研究所湛江 524088
- 作者简介：
  
  E-mail: lichengpeng@gdou.edu.cn
- 基金信息：
  
  广东省自然科学基金(基金号 2024A1515011929);广东省研究生联合培养基地项目、广东海洋大学科产教融合项目和湛江市科技计划项目(2021A05041)
- DOI：10.11777/j.issn1000-3304.2025.25126
  中图分类号：
- CSTR：32057.14.GFZXB.2025.7480
- 收稿：2025-05-18，
  
  录用：2025-09-26，
  
  网络首发：2025-12-15，
  
  纸质出版：2026-02-20
- 稿件说明：
移动端阅览
陈彩怡, 王頔, 李俊杰, 张彤, 李乐凡, 侯婷婷, 廖禄生, 王飞, 李程鹏. Kappa卡拉胶复合凝胶微针敷料的设计及感染创面应用. 高分子学报, 2026, 57(2), 502-521.

Chen, C. Y.; Wang, D.; Li, J. J.; Zhang, T.; Li, L. F.; Hou, T. T.; Liao, L. S.; Wang, F.; Li, C. P. Design of Kappa carrageenan composite gel microneedle dressing and application to infected wounds. Acta Polymerica Sinica (in Chinese), 2026, 57(2), 502-521.
陈彩怡, 王頔, 李俊杰, 张彤, 李乐凡, 侯婷婷, 廖禄生, 王飞, 李程鹏. Kappa卡拉胶复合凝胶微针敷料的设计及感染创面应用. 高分子学报, 2026, 57(2), 502-521. DOI： 10.11777/j.issn1000-3304.2025.25126. CSTR： 32057.14.GFZXB.2025.7480.

Chen, C. Y.; Wang, D.; Li, J. J.; Zhang, T.; Li, L. F.; Hou, T. T.; Liao, L. S.; Wang, F.; Li, C. P. Design of Kappa carrageenan composite gel microneedle dressing and application to infected wounds. Acta Polymerica Sinica (in Chinese), 2026, 57(2), 502-521. DOI： 10.11777/j.issn1000-3304.2025.25126. CSTR： 32057.14.GFZXB.2025.7480.

摘要

Kappa卡拉胶(KC)是一种线性硫酸化多糖，因其优异的凝胶性、生物相容性和溶解性，在创伤敷料和药物控释领域具有广阔的应用前景. 为解决传统敷料在感染创面治疗过程中存在的愈合时间长、感染风险高、患者依从性差等问题，本工作采用甲基丙烯酸酐衍生化的KC (MAKC)为大分子交联剂，以

-羟乙基丙烯酰胺(HEAA)为共聚单体，以肉桂醛-羟乙基-

-环糊精包合物为抗菌剂，开发了一种新型KC复合凝胶微针敷料，并对KC复合凝胶微针的力学性能、体外释放、抑菌性能和治疗效果进行了评价. 核磁共振与元素分析结果表明，MAKC中甲基丙烯酸酐的接枝率为32.02%. 力学性能测试表明，所得KC复合凝胶微针压缩强度在(0.07±0.02)~(0.25±0.02)

/needle之间，能满足皮肤穿透要求. 定量分析表明，包合物中肉桂醛的最大载药率可达(6.69±0.31)%；且KC复合凝胶微针中羟乙基-

-环糊精的释放遵从 Higuchi模型方程，为骨架扩散机制. 抗菌实验表明，KC复合凝胶微针对表皮葡萄球菌和大肠杆菌的抑菌率分别为(90.29±3.10)%和(93.16±2.42)%. 体外细胞及溶血实验证实KC复合凝胶微针具有良好的细胞和血液相容性. SD大鼠感染创面模型表明，KC复合凝胶微针的抗菌效果与模型药物莫匹罗星相当，创面愈合率第11天达(89.42±0.88)%. HE与Masson染色显示其可显著促进上皮增生与胶原有序沉积. 综上，KC复合凝胶微针兼具良好的抗菌、生物相容性和促修复功能，为感染性创面治疗提供了新的解决方案，具有广阔的临床应用前景.

Abstract

Kappa carrageenan (KC)

a linear sulfated polysaccharide

has a broad application prospect in the field of trauma dressing and drug controlled release due to its excellent gelation

biocompatibility and solubility. In order to solve the problems of long healing time

high risk of infection

and poor patient compliance during the treatment of infected wounds with traditional dressings

this study employed methacrylic anhydride derivatised KC (MAKC) as a macromolecular cross-linking agent

-hydroxyethyl acrylamide (HEAA) as a copolymerising monomer

and cinnamaldehyde-hydroxyethyl-

-cyclodextrin inclusion compound as an antimicrobial agent

and developed a novel KC composite gel microneedle dressing

and the mechanical properties

in vitro release

antibacterial properties and therapeutic effects of KC composite gel microneedles were evaluated. The results of nuclear magnetic resonance (NMR) and elemental analysis showed that the grafting rate of methacrylic anhydride in MAKC was 32.02%. Mechanical property tests showed that the compressive strength of the resulting KC composite gel microneedles ranged from (0.07±0.02) N/needle to (0.25±0.02) N/needle

which could meet the skin penetration requirements. Quantitative analysis showed that the maximum drug loading rate of cinnamaldehyde in the inclusion complex could reach (6.69±0.31)%; and the release of hydroxyethyl-

-cyclodextrin from the KC composite gel microneedles followed the Higuchi model equation for a skeletal diffusion mechanism. Antibacterial experiments showed that the inhibition rates of KC composite gel microneedles against

Staphylococcus epidermidis

and

Escherichia coli

were (90.29±3.10)% and (93.16±2.42)%

respectively.

In vitro

cellular and haemolysis experiments confirmed that KC composite gel microneedles had good cellular and haematological compatibility. SD rats infected wound model showed that the antibacterial effect of KC composite gel microneedles was comparable to that of the model drug

mupirocin

and the wound healing rate reached (89.42±0.88)% on the 11

day. HE and Masson staining showed that it could significantly promote the proliferation of epithelium and the orderly deposition of c

ollagen. In conclusion

KC composite gel microneedle has good antibacterial

biocompatibility and pro-repair functions

which provides a new solution for the treatment of infected wounds and has a broad clinical application prospect.

关键词

Keywords

references

Allen C. E. ; Beverley P. C. L. ; Collin M. ; Diamond E. L. ; Egeler R. M. ; Ginhoux F. ; Glass C. ; Minkov M. ; Rollins B. J. ; van Halteren A. The coming of age of langerhans cell histiocytosis . Nat. Immunol , 2019 , 21 ( 1 ), 1 - 7 . doi: 10.1038/s41590-019-0558-z http://dx.doi.org/10.1038/s41590-019-0558-z

Long L. ; Liu W. ; Hu C. ; Yang L. ; Wang Y. Construction of multifunctional wound dressings with their application in chronic wound treatment . Biomater. Sci , 2022 , 10 ( 15 ), 4058 - 4076 . doi: 10.1039/d2bm00620k http://dx.doi.org/10.1039/d2bm00620k

Mahdavinia G. R. ; Mosallanezhad A. ; Soleymani M. ; Sabzi M. Magnetic- and pH-responsive κ -carrageenan/chitosan complexes for controlled release of methotrexate anticancer drug . Int. J. Biol. Macromol , 2017 , 97 , 209 - 217 . doi: 10.1016/j.ijbiomac.2017.01.012 http://dx.doi.org/10.1016/j.ijbiomac.2017.01.012

Dinh L. ; Hong J. ; Min Kim D. ; Lee G. ; Jung ParkE. ; Hyuk Baik S. ; Hwang S. J. A novel thermosensitive poloxamer-hyaluronic acid- kappa-carrageenan-based hydrogel anti-adhesive agent loaded with 5-fluorouracil: a preclinical study in sprague-dawley rats . Int. J. Pharm , 2022 , 621 , 121771 . doi: 10.1016/j.ijpharm.2022.121771 http://dx.doi.org/10.1016/j.ijpharm.2022.121771

Ijaz U. ; Sohail M. ; Usman Minhas M. ; Khan S. ; Hussain Z. ; Kazi M. ; Ahmed Shah S. ; Mahmood A. ; Maniruzzaman M. Biofunctional hyaluronic acid/ κ -carrageenan injectable hydrogels for improved drug delivery and wound healing . Polymers , 2022 , 14 ( 3 ), 376 . doi: 10.3390/polym14030376 http://dx.doi.org/10.3390/polym14030376

Rochas C. ; Rinaudo M. Activity coefficients of counterions and conformation in kappa-carrageenan systems . Biopolymers , 1980 , 19 ( 9 ), 1675 - 1687 . doi: 10.1002/bip.1980.360190911 http://dx.doi.org/10.1002/bip.1980.360190911

Şen M. ; Erboz E. N. Determination of critical gelation conditions of κ -carrageenan by viscosimetric and FT-IR analyses . Food Res. Int , 2010 , 43 ( 5 ), 1361 - 1364 . doi: 10.1016/j.foodres.2010.03.021 http://dx.doi.org/10.1016/j.foodres.2010.03.021

Yegappan R. ; Selvaprithiviraj V. ; Amirthalingam S. ; Jayakumar R. Carrageenan based hydrogels for drug delivery, tissue engineering and wound healing . Carbohydr. Polym , 2018 , 198 , 385 - 400 . doi: 10.1016/j.carbpol.2018.06.086 http://dx.doi.org/10.1016/j.carbpol.2018.06.086

Yu J. ; Zhang Y. ; Ye Y. ; DiSanto R. ; Sun W. ; Ranson D. ; Ligler F. S. ; Buse J. B. ; Gu Z. Microneedle-array patches loaded with hypoxia-sensitive vesicles provide fast glucose-responsive insulin delivery . Proc. Natl. Acad. Sci . U. S. A., 2015 , 112 ( 27 ), 8260 - 8265 . doi: 10.1073/pnas.1505405112 http://dx.doi.org/10.1073/pnas.1505405112

Rouphael N. G. ; Paine M. ; Mosley R. ; Henry S. ; McAllister D. V. ; Kalluri H. ; Pewin W. ; Frew P. M. ; Yu T. ; Thornburg N. J. ; Kabbani S. ; Lai L. ; Vassilieva E. V. ; Skountzou I. ; Compans R. W. ; Mulligan M. J. ; Prausnitz M. R. ; Group T.-M. S. The safety, immunogenicity, and acceptability of inactivated influenza vaccine delivered by microneedle patch (TIV-MNP 2015): A randomised, partly blinded, placebo-controlled, phase 1 trial . Lancet , 2017 , 390 ( 10095 ), 649 - 658 . doi: 10.1016/s0140-6736(17)30575-5 http://dx.doi.org/10.1016/s0140-6736(17)30575-5

Donnelly R. F. ; McCrudden M. T. ; Zaid Alkilani A. ; Larraneta E. ; McAlister E. ; Courtenay A. J. ; Kearney M. C. ; Singh T. R. ; McCarthy H. O. ; Kett V. L. ; Caffarel-Salvador E. ; Al-Zahrani S. ; Woolfson A. D. Hydrogel-forming microneedles prepared from "super swelling" polymers combined with lyophilised wafers for transdermal drug delivery . PLOS One , 2014 , 9 ( 10 ), e 111547 . doi: 10.1371/journal.pone.0111547 http://dx.doi.org/10.1371/journal.pone.0111547

He R. ; Niu Y. ; Li Z. ; Li A. ; Yang H. ; Xu F. ; Li F. A hydrogel microneedle patch for point-of-care testing based on skin interstitial fluid . Adv. Healthc. Mater , 2020 , 9 ( 4 ), e 1901201 . doi: 10.1002/adhm.201901201 http://dx.doi.org/10.1002/adhm.201901201

Al Sulaiman D. ; Chang J. Y. H. ; Bennett N. R. ; Topouzi H. ; Higgins C. A. ; Irvine D. J. ; Ladame S. Hydrogel-coated microneedle arrays for minimally invasive sampling and sensing of specific circulating nucleic acids from skin interstitial fluid . ACS Nano , 2019 , 13 ( 8 ), 9620 - 9628 . doi: 10.1021/acsnano.9b04783 http://dx.doi.org/10.1021/acsnano.9b04783

Si W. ; Gong J. ; Chanas C. ; Cui S. ; Yu H. ; Caballero C. ; Friendship R. M. In vitro assessment of antimicrobial activity of carvacrol, thymol and cinnamaldehyde towards salmonella serotype typhimurium dt104: effects of pig diets and emulsification in hydrocolloids . J. Appl. Microbiol , 2006 , 101 ( 6 ), 1282 - 1291 . doi: 10.1111/j.1365-2672.2006.03045.x http://dx.doi.org/10.1111/j.1365-2672.2006.03045.x

Liang D. ; Feng B. ; Li N. ; Su L. ; Wang Z. ; Kong F. ; Bi Y. Preparation, characterization, and biological activity of cinnamomum cassia essential oil nano-emulsion . Ultrason. Sonochem , 2022 , 86 , 106009 . doi: 10.1016/j.ultsonch.2022.106009 http://dx.doi.org/10.1016/j.ultsonch.2022.106009

Lai W. ; Liu Y. ; Kuang Y. ; Zhang S. ; Zhang C. ; Li C. ; Guo B. Preparation and evaluation of microcapsules containing rimulus cinnamon and angelica sinenis essential oils . J. Dispersion Sci. Technol , 2023 , 44 ( 14 ), 2639 - 2650 . doi: 10.1080/01932691.2022.2116716 http://dx.doi.org/10.1080/01932691.2022.2116716

Lu Y. Y. ; Yu H. J. ; Wang L. ; Shen D. ; Liu J. Preparation of phenylboronic acid-based glucose-responsive hydrogels and microneedles for regulated delivery of insulin . Eur. Polym. J. , 2023 , 192 , 112061 . doi: 10.1016/j.eurpolymj.2023.112061 http://dx.doi.org/10.1016/j.eurpolymj.2023.112061

Yu W. ; Li X. ; He J. ; Chen Y. ; Qi L. ; Yuan P. ; Ou K. ; Liu F. ; Zhou Y. ; Qin X. Graphene oxide-silver nanocomposites embedded nanofiber core-spun yarns for durable antibacterial textiles . J. Colloid Interface Sci. , 2021 , 584 , 164 - 173 . doi: 10.1016/j.jcis.2020.09.092 http://dx.doi.org/10.1016/j.jcis.2020.09.092

Faria M. ; Geraldes V. ; de Pinho M. N. Surface characterization of asymmetric Bi-soft segment poly(ester urethane urea) membranes for blood-oxygenation medical devices . Int. J. Biomater. , 2012 , 2012 , 376321 . doi: 10.1155/2012/376321 http://dx.doi.org/10.1155/2012/376321

Liao J. ; Zheng H. ; Fei Z. ; Lu B. ; Zheng H. ; Li D. ; Xiong X. ; Yi Y. Tumor-targeting and ph-responsive nanoparticles from hyaluronic acid for the enhanced delivery of doxorubicin . Int. J. Biol. Macromol. , 2018 , 113 , 737 - 747 . doi: 10.1016/j.ijbiomac.2018.03.004 http://dx.doi.org/10.1016/j.ijbiomac.2018.03.004

Teparat-Burana T. ; Onsiri N. ; Jantarat J. Cytotoxicity and migration of fibroblasts on two types of calcium sulfate dihydrate . J. Investig. Clin. Dent. , 2017 , 8 ( 1 ), 26215703 . doi: 10.1111/jicd.12177 http://dx.doi.org/10.1111/jicd.12177

Walter M. N. ; Wright K. T. ; Fuller H. R. ; MacNeil S. ; Johnson W. E. Mesenchymal stem cell-conditioned medium accelerates skin wound healing: an in vitro study of fibroblast and keratinocyte scratch assays . Exp. Cell Res. , 2010 , 316 ( 7 ), 1271 - 1281 . doi: 10.1016/j.yexcr.2010.02.026 http://dx.doi.org/10.1016/j.yexcr.2010.02.026

Rode H. ; Hanslo D. ; de Wet P. M. ; Millar A. J. ; Cywes S. Efficacy of mupirocin in methicillin-resistant staphylococcus aureus burn wound infection . Antimicrob. Agents Chemother. , 1989 , 33 ( 8 ), 1358 - 1361 . doi: 10.1128/aac.33.8.1358 http://dx.doi.org/10.1128/aac.33.8.1358

Hu S. ; Cai X. ; Qu X. ; Yu B. ; Yan C. ; Yang J. ; Li F. ; Zheng Y. ; Shi X. Preparation of biocompatible wound dressings with long-term antimicrobial activity through covalent bonding of antibiotic agents to natural polymers . Int. J. Biol. Macromol , 2019 , 123 , 1320 - 1330 . doi: 10.1016/j.ijbiomac.2018.09.122 http://dx.doi.org/10.1016/j.ijbiomac.2018.09.122

de Moraes F. M. ; Philippi J. V. ; Belle F. ; da Silva F. S. ; Morisso F. D. P. ; Volz D. R. ; Ziulkoski A. L. ; Bobinski F. ; Zepon Κ M. Iota-carrageenan/xyloglucan/serine powders loaded with tranexamic acid for simultaneously hemostatic, antibacterial, and antioxidant performance . Biomater. Adv. , 2022 , 137 , 212805 . doi: 10.1016/j.bioadv.2022.212805 http://dx.doi.org/10.1016/j.bioadv.2022.212805

Prado-Fernández J. ; Rodrı́guez-Vázquez J. A. ; Tojo E. ; Andrade J. M. Quantitation of κ -, ι - and λ -carrageenans by mid-infrared spectroscopy and PLS regression . Anal. Chim. Acta , 2003 , 480 ( 1 ), 23 - 37 . doi: 10.1016/s0003-2670(02)01592-1 http://dx.doi.org/10.1016/s0003-2670(02)01592-1

Noralian Z. ; Gashti M. P. ; Moghaddam M. R. ; Tayyeb H. ; Erfanian I. Ultrasonically developed silver/iota-carrageenan/cotton bionanocomposite as an efficient material for biomedical applications . Int. J. Biol. Macromol. , 2021 , 180 , 439 - 457 . doi: 10.1016/j.ijbiomac.2021.02.204 http://dx.doi.org/10.1016/j.ijbiomac.2021.02.204

Mihaila S. M. ; Gaharwar A. K. ; Reis R. L. ; Marques A. P. ; Gomes M. E. ; Khademhosseini A. Photocrosslinkable kappa‐carrageenan hydrogels for tissue engineering applications . Adv. Healthc. Mater , 2012 , 2 ( 6 ), 895 - 907 . doi: 10.1002/adhm.201200317 http://dx.doi.org/10.1002/adhm.201200317

Ungaro F. ; d'Emmanuele di Villa Bianca, R. ; Giovino C. ; Miro A. ; Sorrentino R. ; Quaglia F. ; La Rotonda M. I. Insulin-loaded PLGA/cyclodextrin large porous particles with improved aerosolization properties: in vivo deposition and hypoglycaemic activity after delivery to rat lungs . J. Control. Rel. , 2009 , 135 ( 1 ), 25 - 34 . doi: 10.1016/j.jconrel.2008.12.011 http://dx.doi.org/10.1016/j.jconrel.2008.12.011

Villaverde J. ; Morillo E. ; Pérez-Martínez J. I. ; Ginés J. M. ; Maqueda C. Preparation and characterization of inclusion complex of norflurazon and β -cyclodextrin to improve herbicide formulations . J. Agric. Food. Chem , 2004 , 52 ( 4 ), 864 - 869 . doi: 10.1021/jf0350358 http://dx.doi.org/10.1021/jf0350358

Tian Y. C. ; Yuan C. ; Cui B. ; Lu L. ; Zhao M. ; Liu P. F. ; Wu Z. Z. ; Li J. P. Pickering emulsions stabilized by β-cyclodextrin and cinnamaldehyde essential oil/β-cyclodextrin composite: A comparison study . Food Chem. , 2022 , 377 , 131995 . doi: 10.1016/j.foodchem.2021.131995 http://dx.doi.org/10.1016/j.foodchem.2021.131995

Zhu J. X. ; Zhou X. W. ; Kim H. J. ; Qu M. Y. ; Jiang X. ; Lee K. ; Ren L. ; Wu Q. Z. ; Wang C. R. ; Zhu X. M. ; Tebon P. ; Zhang S. M. ; Lee J. ; Ashammakhi N. ; Ahadian S. ; Dokmeci M. R. ; Gu Z. ; Sun W. J. ; Khademhosseini A. Gelatin methacryloyl microneedle patches for minimally invasive extraction of skin interstitial fluid . Small , 2020 , 16 ( 16 ), 1905910 . doi: 10.1002/smll.202070086 http://dx.doi.org/10.1002/smll.202070086

Zhu W. ; Mei J. ; Xianzuo Z. ; Zhou J. ; Xu D. ; Su Z. ; Fang S. ; Wang J. ; Zhang X. ; Zhu C. Photothermal nanozyme-based microneedle patch against refractory bacterial biofilm infection via iron-actuated janus ion therapy . Adv. Mater. , 2022 , 34 ( 51 ), 2207961 . doi: 10.1002/adma.202207961 http://dx.doi.org/10.1002/adma.202207961

Jiang S. ; Li J. N. ; Jiang Z. T. Inclusion reactions of β-cyclodextrin and its derivatives with cinnamaldehyde in cinnamomum loureirii essential oil . Eur. Food Res. Technol , 2010 , 230 ( 4 ), 543 - 550 . doi: 10.1007/s00217-009-1192-z http://dx.doi.org/10.1007/s00217-009-1192-z

杨艺 , 郭禹良 , 褚宏喆 , 周丽芸 , 宗益峰 , 刘杨 . 湿敏型二氧化氯缓释剂的制备和表征 . 包装工程 , 2024 , 45 ( 17 ), 87 - 95 .

吴春 , 张艳 , 徐丽萍 . 原花青素微胶囊释放动力学的研究 . 化学与粘合 , 2007 , ( 03 ), 172 - 175 .

Shu C. ; Ge L. ; Li Z. ; Chen B. ; Liao S. ; Lu L. ; Wu Q. ; Jiang X. ; An Y. ; Wang Z. ; Qu M. Antibacterial activity of cinnamon essential oil and its main component of cinnamaldehyde and the underlying mechanism . Front Pharmacol , 2024 , 15 , 1378434 - 1378434 . doi: 10.3389/fphar.2024.1378434 http://dx.doi.org/10.3389/fphar.2024.1378434

Choi Y. H. Trans-cinnamaldehyde protects C 2 C12 damagemyoblastsfrom DNA, mitochondrial dysfunction and apoptosis caused by oxidative stress through inhibiting ros production. Genes & genomics , 2021 , 43 ( 4 ), 303 - 312 . doi: 10.1007/s13258-020-00987-9 http://dx.doi.org/10.1007/s13258-020-00987-9

Liu X. ; Rodeheaver D. P. ; White J. C. ; Wright A. M. ; Walker L. M. ; Zhang F. ; Shannon S. A comparison of in vitro cytotoxicity assays in medical device regulatory studies . Regul. Toxicol. Pharm. , 2018 , 97 , 24 - 32 . doi: 10.1016/j.yrtph.2018.06.003 http://dx.doi.org/10.1016/j.yrtph.2018.06.003

Kravchenko A. O. ; Menchinskaya E. S. ; Isakov V. V. ; Glazunov V. P. ; Yermak I. M. Carrageenans and their oligosaccharides from red seaweeds ahnfeltiopsis flabelliformis and mastocarpus pacificus (phyllophoraceae) and their antiproliferative activity . Int. J. Mol. Sci. , 2023 , 24 ( 8 ), 7657 . doi: 10.3390/ijms24087657 http://dx.doi.org/10.3390/ijms24087657

Yang X. ; Jia M. ; Li Z. ; Ma Z. ; Lv J. ; Jia D. ; He D. ; Zeng R. ; Luo G. ; Yu Y. In-situ synthesis silver nanoparticles in chitosan/bletilla striata polysaccharide composited microneedles for infected and susceptible wound healing . Int. J. Biol. Macromol. , 2022 , 215 , 550 - 559 . doi: 10.1016/j.ijbiomac.2022.06.131 http://dx.doi.org/10.1016/j.ijbiomac.2022.06.131

Luo R. ; Xian D. ; Li F. ; Zhou G. ; Jiang L. ; Wu J. ; Lin L. ; Zheng Y. ; Liu G. ; Xu Q. ; Pan X. ; Wu C. ; Peng T. ; Quan G. ; Lu C. Epsilon-poly-l-lysine microneedle patch loaded with amorphous doxycycline nanoparticles for synergistic treatment of skin infection . Int. J. Biol. Macromol. , 2024 , 266 , 131383 . doi: 10.1016/j.ijbiomac.2024.131383 http://dx.doi.org/10.1016/j.ijbiomac.2024.131383

Tavakoli S. ; Klar A. S. Advanced hydrogels as wound dressings . Biomolecules , 2020 , 10 ( 8 ), 1169 . doi: 10.3390/biom10081169 http://dx.doi.org/10.3390/biom10081169

Alshammari O. A. O. ; Alhar M. S. O. ; Al-Otaibi A. ; AlRashidi A. A. ; Alshammari A. F. ; Alzahrani E. A. ; Elsayed N. H. ; Monier M. ; Youssef I. Synthesis of photo-responsive κ -carrageenan-based hydrogels for drug delivery application . Int. J. Biol. Macromol. , 2025 , 289 , 138797 . doi: 10.1016/j.ijbiomac.2024.138797 http://dx.doi.org/10.1016/j.ijbiomac.2024.138797

Lei X. L. ; Cheng K. ; Li Y. ; Zhong Z. T. ; Hou X. L. ; Song L. B. ; Zhang F. ; Wang J. H. ; Zhao Y. D. ; Xu Q. R. The eradication of biofilm for therapy of bacterial infected chronic wound based on pH-responsive micelle of antimicrobial peptide derived biodegradable microneedle patch . Chem. Eng. J. , 2023 , 462 , 142222 . doi: 10.1016/j.cej.2023.142222 http://dx.doi.org/10.1016/j.cej.2023.142222

Gao S. ; Rao Y. ; Wang X. ; Zhang Q. ; Zhang Z. ; Wang Y. ; Guo J. ; Yan F. Chlorella-loaded antibacterial microneedles for microacupuncture oxygen therapy of diabetic bacterial infected wounds . Adv. Mater. , 2024 , 36 ( 15 ), 2307585 . doi: 10.1002/adma.202307585 http://dx.doi.org/10.1002/adma.202307585

Tian S. ; Mei J. ; Zhang L. ; Wang S. ; Yuan Y. ; Li J. ; Liu H. ; Zhu W. ; Xu D. Multifunctional hydrogel microneedle patches modulating oxi‐inflamm‐aging for diabetic wound healing . Small , 2024 , 20 ( 51 ), e 2407340 . doi: 10.1002/smll.202407340 http://dx.doi.org/10.1002/smll.202407340

Lu X. ; Zhang J. ; Zuo W. ; Cheng B. ; Dong R. ; Wang W. ; Lu L. A dissolving microneedle patch loaded with plumbagin/hydroxypropyl- β -cyclodextrin inclusion complex for infected wound healing . Colloids Surf. B , 2025 , 246 , 114377 . doi: 10.1016/j.colsurfb.2024.114377 http://dx.doi.org/10.1016/j.colsurfb.2024.114377

Xue B. ; Yao Y. ; Luo E. ; Lessing D. J. ; Guo M. ; Chu W. An integrated therapeutic nanoparticles and quorum quenching-based microneedle patch for bacterial-infected wound healing . Advanced Therapeutics , 2025 , 8 ( 1 ), 2400405 . doi: 10.1002/adtp.202400405 http://dx.doi.org/10.1002/adtp.202400405

Qin K. ; Gui Y. ; Li Y. ; Li X. ; Meng F. ; Han D. ; Du L. ; Li S. ; Wang Y. ; Zhou H. ; Yan H. ; Peng Y. ; Gao Z. Biodegradable microneedle array-mediated transdermal delivery of dimethyloxalylglycine-functionalized zeolitic imidazolate framework-8 nanoparticles for bacteria-infected wound treatment . ACS Appl. Mater. Interfaces , 2023 , 15 ( 5 ), 6338 - 6353 . doi: 10.1021/acsami.2c17328 http://dx.doi.org/10.1021/acsami.2c17328

Ye G. ; Jimo R. ; Lu Y. ; Kong Z. ; Axi Y. ; Huang S. ; Xiong Y. ; Zhang L. ; Chen G. ; Xiao Y. ; Li P. ; Gou K. ; Zeng R. Multifunctional natural microneedles based methacrylated bletilla striata polysaccharide for repairing chronic wounds with bacterial infections . Int. J. Biol. Macromol , 2024 , 254 , 127914 . doi: 10.1016/j.ijbiomac.2023.127914 http://dx.doi.org/10.1016/j.ijbiomac.2023.127914

Lei X. ; Li M. ; Wang C. ; Cui P. ; Qiu L. ; Zhou S. ; Jiang P. ; Li H. ; Zhao D. ; Ni X. ; Wang J. ; Xia J. Degradable microneedle patches loaded with antibacterial gelatin nanoparticles to treat staphylococcal infection-induced chronic wounds . Int. J. Biol. Macromol , 2022 , 217 , 55 - 65 . doi: 10.1016/j.ijbiomac.2022.07.021 http://dx.doi.org/10.1016/j.ijbiomac.2022.07.021

Li Y. ; Gong J. Y. ; Wang P. ; Fu H. ; Yousef F. ; Xie R. ; Wang W. ; Liu Z. ; Pan D. W. ; Ju X. J. ; Chu L. Y. Dissolving microneedle system containing ag nanoparticle-decorated silk fibroin microspheres and antibiotics for synergistic therapy of bacterial biofilm infection . J. Colloid Interface Sci , 2024 , 661 , 123 - 138 . doi: 10.1016/j.jcis.2024.01.147 http://dx.doi.org/10.1016/j.jcis.2024.01.147

Krishnakumar A. ; Gallina N. L. F. ; Sarnaik D. ; McCain R. R. ; Crain C. ; Tipton M. ; Seleem M. ; Bhunia A. K. ; Rahimi R. Microneedles for enhanced bacterial pathogen inactivation and accelerated wound healing . Adv. Mater. Technol , 2024 , 9 ( 16 ), 2400219 . doi: 10.1002/admt.202400219 http://dx.doi.org/10.1002/admt.202400219

浏览量

642

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

暂无数据