基于电纺膜骨架的压电抗菌壳聚糖水凝胶薄膜的研究

周廖敏; 郑好; 葛黎明; 李德富; 徐志朗; 穆畅道

doi:10.11777/j.issn1000-3304.2025.25183

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基于电纺膜骨架的压电抗菌壳聚糖水凝胶薄膜的研究

研究论文 | 更新时间：2026-02-09

- 基于电纺膜骨架的压电抗菌壳聚糖水凝胶薄膜的研究
- Piezoelectric Antibacterial Chitosan Hydrogel Films Based on Electrospun Membrane Skeletons
- 高分子学报 2026年57卷第2期页码：490-501
- 作者机构：
  
  四川大学化学工程学院制药与生物工程系成都 610065
- 作者简介：
  
  E-mail: xuzhilang@scu.edu.cn
- 基金信息：
  
  国家自然科学基金(基金号 ┣22578288);22505169┫;四川省自然科学基金(基金号 2024NSFSC1095);中央高校基础研究基金(基金号 2023SCU12079)
- DOI：10.11777/j.issn1000-3304.2025.25183
  中图分类号：
- CSTR：32057.14.GFZXB.2025.7485
- 收稿：2025-09-12，
  
  录用：2025-10-09，
  
  网络首发：2025-12-26，
  
  纸质出版：2026-02-20
- 稿件说明：
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周廖敏, 郑好, 葛黎明, 李德富, 徐志朗, 穆畅道. 基于电纺膜骨架的压电抗菌壳聚糖水凝胶薄膜的研究. 高分子学报, 2026, 57(2), 490-501.

Zhou, L. M.; Zheng, H.; Ge, L. M.; Li, D. F.; Xu, Z. L.; Mu, C. D. Piezoelectric antibacterial chitosan hydrogel films based on electrospun membrane skeletons. Acta Polymerica Sinica (in Chinese), 2026, 57(2), 490-501.
周廖敏, 郑好, 葛黎明, 李德富, 徐志朗, 穆畅道. 基于电纺膜骨架的压电抗菌壳聚糖水凝胶薄膜的研究. 高分子学报, 2026, 57(2), 490-501. DOI： 10.11777/j.issn1000-3304.2025.25183. CSTR： 32057.14.GFZXB.2025.7485.

Zhou, L. M.; Zheng, H.; Ge, L. M.; Li, D. F.; Xu, Z. L.; Mu, C. D. Piezoelectric antibacterial chitosan hydrogel films based on electrospun membrane skeletons. Acta Polymerica Sinica (in Chinese), 2026, 57(2), 490-501. DOI： 10.11777/j.issn1000-3304.2025.25183. CSTR： 32057.14.GFZXB.2025.7485.

摘要

细菌感染会对人类健康造成持续性威胁，抗生素的滥用导致多重耐药细菌的产生，严重危害世界公共卫生安全，因此亟需发展新型可靠的抗菌功能材料. 具有机电转换能力的压电材料凭借独特的抗菌机理而受到不断的关注. 本研究使用静电纺丝技术制备了负载压电陶瓷钛酸钡纳米颗粒的聚(3-羟基丁酸酯)电纺膜，钛酸钡为电纺膜提供稳定的压电信号；再将电纺膜作为骨架，以甲基丙烯酸酐改性制备的双键壳聚糖在表面和内部光引发聚合形成水凝胶薄膜. 研究表明，制备的压电水凝胶薄膜具有优异的压电性能、机械性能、黏附性能，良好的热稳定性、溶胀性能、降解性能和生物相容性，并且对大肠杆菌(

E. coli

)和金黄色葡萄球菌(

S. aureus

)表现出显著的抗菌效果. 本研究构建了一种行之有效的压电抗菌水凝胶薄膜，为伤口感染及感染性骨缺损的治疗等提供了新思路.

Abstract

Bacterial infections pose a persistent threat to human health

and the overuse of antibiotics has led to the emergence of multidrug-resistant bacteria

severely jeopardizing global public health security. Therefore

there is an urgent need to develop novel

reliable antimicrobial functional materials. Piezoelectric materials with electromechanical conversion capabilities have garnered increasing attention due to their unique antimicrobial mechanisms. In this study

poly(3-hydroxybutyrate) films loaded with piezoelectric ceramic barium titanate nanoparticles were prepared using electrospinning technology. The barium titanate provided a stable piezoelectric signal for the electrospun membrane; The electrospun membrane was then used as a scaffold

and hydrogel films was formed through photoinitiated polymerization of methacrylic acid-modified double-bonded chitosan on the surface and interior. The study demonstrated that the prepared piezoelectric hydrogel films exhibit excellent piezoelectric properties

mechanical properties

adhesive properties

good thermal stability

swelling properties

degradability

and biocompatibility

as well as significant antibacterial effects against

Escherichia coli

(

E. coli

) and

Staphylococcus aureus

(

S. aureus

). In summary

this study developed an effective piezoelectric antibacterial hydrogel film

providing new insights for the treatment of wound infections and infectious bone defects.

关键词

Keywords

references

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