生物医用杂萘联苯聚芳醚砜酮及其性能研究

袁佳怡; 柳承德; 沈月; 李怡铮; 程习彤; 张守海; 孙振龙; 王晗; 蹇锡高

doi:10.11777/j.issn1000-3304.2025.25267

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生物医用杂萘联苯聚芳醚砜酮及其性能研究

研究论文 | 更新时间：2026-01-16

- 生物医用杂萘联苯聚芳醚砜酮及其性能研究
- Systematic Study on Synthesis, Purification, and Performance of Biomedical Poly(phthalazinone ether sulfone ketone)
- 高分子学报 2026年57卷第1期页码：282-291
- 作者机构：
  
  1.大连理工大学，精细化工国家重点实验室，威海 264210
  2.大连理工大学，高分子材料系，威海 264210
  3.大连理工大学，辽宁省高性能树脂工程技术研究中心大连 116024 ，威海 264210
  4.大连理工大学，威高集团有限公司，威海 264210
- 作者简介：
  
  E-mail: liucd@dlut.edu.cn
  jian4616@dlut.edu.cn
- 基金信息：
  
  中央高校基本科研业务费专项资金(DUT24YG134);中石化集团基金(基金号 ┣224031);225061┫;国家自然科学基金(基金号 52503167);中国科学院-威高研究发展计划项目
- DOI：10.11777/j.issn1000-3304.2025.25267
  中图分类号：
- CSTR：32057.14.GFZXB.2025.7539
- 收稿：2025-10-17，
  
  录用：2025-12-16，
  
  网络出版：2026-01-05，
  
  纸质出版：2026-01-20
- 稿件说明：
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袁佳怡, 柳承德, 沈月, 李怡铮, 程习彤, 张守海, 孙振龙, 王晗, 蹇锡高. 生物医用杂萘联苯聚芳醚砜酮及其性能研究. 高分子学报, 2026, 57(1), 282-291.

Yuan, J. Y.; Liu, C. D.; Shen, Y.; Li, Y. Z.; Cheng, X. T.; Zhang, S. H.; Sun, Z. L.; Wang, H.; Jian, X. G. Systematic study on synthesis, purification, and performance of biomedical poly(phthalazinone ether sulfone ketone). Acta Polymerica Sinica (in Chinese), 2026, 57(1), 282-291.
袁佳怡, 柳承德, 沈月, 李怡铮, 程习彤, 张守海, 孙振龙, 王晗, 蹇锡高. 生物医用杂萘联苯聚芳醚砜酮及其性能研究. 高分子学报, 2026, 57(1), 282-291. DOI： 10.11777/j.issn1000-3304.2025.25267. CSTR： 32057.14.GFZXB.2025.7539.

Yuan, J. Y.; Liu, C. D.; Shen, Y.; Li, Y. Z.; Cheng, X. T.; Zhang, S. H.; Sun, Z. L.; Wang, H.; Jian, X. G. Systematic study on synthesis, purification, and performance of biomedical poly(phthalazinone ether sulfone ketone). Acta Polymerica Sinica (in Chinese), 2026, 57(1), 282-291. DOI： 10.11777/j.issn1000-3304.2025.25267. CSTR： 32057.14.GFZXB.2025.7539.

摘要

杂萘联苯聚芳醚砜酮(PPESK)作为一种兼具优异热稳定性和良好溶解性的高性能工程塑料，在生物医用材料领域展现出广阔应用前景，高效纯化技术是生物医用材料制备的关键技术. 本研究采用亲核取代逐步聚合反应制备PPESK，并通过优化反应终止条件以降低粗产物中杂质含量. 针对残留金属离子和有机杂质，采用不同条件对PPESK粗产物进行纯化，系统表征了搅拌水洗PPESK (PPESK-W)、加热搅拌水洗PPESK (PPESK-HW)及超声加热水洗PPESK (PPESK-UHW)杂质含量及生物相容性. 结果表明，超声加热水洗可显著提升杂质去除效率，使钾、钙、钠、铁等金属离子含量分别降至77.3、254.2、115.1和22.8 mg/kg，与生物相容性直接相关的重金属杂质总量降至18.67 mg/kg，总挥发性有机物(TVOC)含量降至5 mg/kg. 通过MTT、CCK-8、活/死细胞染色及细胞贴附等生物学实验验证生物相容性，相较于未纯化的PPESK，PPESK-UHW对细胞活性的抑制作用降低，细胞增殖速率加快，细胞存活率提高，且细胞骨架伸展充分，形态发育良好. 研究表明，超声有效促进了杂质去除，为获得高纯度、高生物相容性的医用PPESK材料提供了关键技术支撑.

Abstract

Poly(phthalazinone ether sulfone ketone) (PPESK)

a high-performance engineering plastic with excellent thermal stability and good solubility

shows promising potential in biomedical applications. Efficient purification is a key technology in the preparation of biomedical materials. In this study

PPESK was synthesized

via

nucleophilic substitution step-growth polymerization

and the impurity content in the crude product was minimized by optimizing the reaction termination conditions. To remove residual metal ions and organic impurities

various purification methods were applied to the crude PPESK

and the resulting materials—water-washed PPESK (PPESK-W)

heated water-washed PPESK (PPESK-HW)

and ultrasonically heated water-washed PPESK (PPESK-UHW)—were systematically characterized in terms of impurity content and biocompatibility. Results demonstrated that ultrasonic heating significantly enhanced impurity removal efficiency

reducing the contents of potassium

calcium

sodium

and iron to 77.3

254.2

115.1

and 22.8 mg/kg

respectively. The total concentration of heavy metals relevant to biocompatibility was reduced to 18.67 mg/kg

and the total volatile organic compounds (TVOC) decreased to 5 mg/kg. Biocompatibility was evaluated through MTT

CCK-8

live/dead cell staining

and cell adhesion assays. Compared to the unpurified PPESK

PPESK-UHW exhibited reduced cytotoxicity

promoted cell proliferation

higher cell viability

and well-spread cytoskeletal structures with favorable morphological development. This study confirms that ultrasound effectively facilitates impurity removal

providing a critical techni

cal foundation for producing high-purity

highly biocompatible medical-grade PPESK materials.

关键词

Keywords

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