氨基酸基材料在基因与药物传递领域的应用

漆李矜; 黄琪杨; 高晴妤; 韩笛; 廖馨茹; 张先正; 程巳雪

doi:10.11777/j.issn1000-3304.2024.24226

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氨基酸基材料在基因与药物传递领域的应用

专论 | 更新时间：2025-01-26

- 氨基酸基材料在基因与药物传递领域的应用
- Amino Acid-based Materials for Gene and Drug Delivery
- 高分子学报 2025年56卷第1期页码：1-25
- 作者机构：
  
  生物医用高分子材料教育部重点实验室武汉大学化学与分子科学学院武汉 430072
- 作者简介：
  
  [ "程巳雪，女，1971年生. 武汉大学化学与分子科学学院生物医用高分子材料教育部重点实验室教授，博士生导师. 1992年于华南理工大学获学士学位，1995年于中国科学技术大学获硕士学位，2000年于新加坡国立大学获博士学位. 2000年1月至2001年1月在新加坡材料研究与工程研究所任助理研究员，2001年1月起在武汉大学生物医用高分子材料教育部重点实验室工作. 主要研究方向为生物医用材料、基因及药物传递系统、疾病诊疗系统." ]
- 基金信息：
  
  国家自然科学基金(基金号 51988102)
- DOI：10.11777/j.issn1000-3304.2024.24226
  中图分类号：
- CSTR：32057.14.GFZXB.2024.7310
- 纸质出版日期：2025-01-20，
  
  网络出版日期：2024-12-11，
  
  收稿日期：2024-08-27，
  
  录用日期：2024-10-17
- 稿件说明：
移动端阅览
漆李矜, 黄琪杨, 高晴妤, 韩笛, 廖馨茹, 张先正, 程巳雪. 氨基酸基材料在基因与药物传递领域的应用. 高分子学报, 2025, 56(1), 1-25

Qi, L. J.; Huang, Q. Y.; Gao, Q. Y.; Han, D.; Liao, X. R.; Zhang, X. Z.; Cheng, S. X. Amino acid-based materials for drug and gene delivery. Acta Polymerica Sinica, 2025, 56(1), 1-25
漆李矜, 黄琪杨, 高晴妤, 韩笛, 廖馨茹, 张先正, 程巳雪. 氨基酸基材料在基因与药物传递领域的应用. 高分子学报, 2025, 56(1), 1-25 DOI： 10.11777/j.issn1000-3304.2024.24226. CSTR： 32057.14.GFZXB.2024.7310.

Qi, L. J.; Huang, Q. Y.; Gao, Q. Y.; Han, D.; Liao, X. R.; Zhang, X. Z.; Cheng, S. X. Amino acid-based materials for drug and gene delivery. Acta Polymerica Sinica, 2025, 56(1), 1-25 DOI： 10.11777/j.issn1000-3304.2024.24226. CSTR： 32057.14.GFZXB.2024.7310.

摘要

氨基酸基材料如聚氨基酸、多肽、蛋白等具有独特的理化性质、生物活性和良好的生物相容性，在生物医学领域展现出广泛的应用前景，尤其在基因与药物传递领域. 本文介绍了不同类型的氨基酸基材料包括聚氨基酸、多肽、蛋白及其功能化衍生物在基因和药物传递中的应用及研究进展，简述了氨基酸基传递载体与其他材料比较的优势，总结了常见的提高氨基酸基载体性能的策略，重点分析了这些材料在促进基因与药物传递及提高疾病疗效方面的作用和机制，包括通过优化载体材料的结构与性能提高基因及药物传递效率；利用载体材料实现组织、细胞及细胞器的靶向递送、刺激响应性递送；提高载体克服细胞外及细胞内传递屏障的能力等. 指出了本领域所面临的问题和挑战，提出了对材料研发及实际应用的建议和思路.

Abstract

Amino acid-based materials

including poly(amino acids)

peptides

and proteins

possess distinct physicochemical properties

biological activities

and exceptional biocompatibility

rendering them highly attractive for diverse biomedical applications

particularly in gene and drug delivery. This article provides a comprehensive overview of the applications and recent research progress of amino acid-based materials and their functional derivatives in gene and drug delivery

highlighting the advantages of these carriers over conventional materials. Common strategies aimed at enhancing the efficacy of amino acid-based gene and drug delivery vectors are summarized

with a focus on the mechanisms through which these materials facilitate gene and drug delivery to improve therapeutic outcomes. Key strategies include the optimization of carrier material structures and properties to improve delivery efficiency

the achievement of targeted delivery to specific tissues

cells

and organelles

and the development of approaches to overcome extracellular and intracellular delivery barriers. Specifically

three categories of amino acid-based materials for gene and drug delivery are discussed. For poly(amino acids)

modification strategies to enhance their performance such as copolymerization

creation of hyperbranched structures

functional modification

combination with other polymer moieties

and incorporation of functional moieties are introduced. For peptides

various types of peptides including cell-penetrating peptides

nuclear localization signals

targeting peptides

stimulus-responsive peptides

chimeric peptides/fusion peptides

and de novo designed peptides are introduced

highlighting their roles in improving gene and drug delivery efficiency. For proteins

nucleic acid-binding proteins

positively charged proteins

protein nanocages for gene delivery

and naturally sourced proteins for drug delivery are presented. By addressing current challenges and issues in this field

recommendations and insights for future material development and practical applications are proposed.

关键词

聚氨基酸多肽蛋白传递载体基因与药物传递

Keywords

Poly(amino acid)PeptideProteinDelivery vectorGene and drug delivery

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