共轭高分子在脑机接口中的应用与展望

潘熙然; 张志; 雷霆

doi:10.11777/j.issn1000-3304.2024.24249

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共轭高分子在脑机接口中的应用与展望

综述 | 更新时间：2025-02-27

- 共轭高分子在脑机接口中的应用与展望
- Application and Prospects of Conjugated Polymers in Brain-Computer Interfaces
- 高分子学报 2025年56卷第3期页码：377-395
- 作者机构：
  
  高分子化学与物理教育部重点实验室北京大学材料科学与工程学院北京 100871
- 作者简介：
  
  [ "张志，女，1991年生，现任北京大学材料科学与工程学院特聘副研究员. 2014年青岛大学获学士学位，2020年获东华大学博士学位，从事纤维电子及可穿戴电子研究. 2021~2023年于北京大学材料科学与工程学院雷霆团队开展博士后研究. 主要从事有机半导体纤维及传感器件的设计、开发与应用研究." ]
  [ "雷霆，男，1987年生，现任北京大学材料科学与工程学院长聘副教授，博士生导师，2024年获国家杰出青年基金资助. 2008、2013年在北京大学化学与分子工程学院分别获学士和博士学位；2013~2018年在斯坦福大学化工系从事博士后研究. 2018年3月加入北京大学开展独立研究. 主要从事有机高分子半导体材料及其在柔性电子和生物电子领域中的应用研究." ]
- 基金信息：
  
  北京市自然科学基金(基金号 JQ22006)
- DOI：10.11777/j.issn1000-3304.2024.24249
  中图分类号：
- CSTR：32057.14.GFZXB.2024.7324
- 收稿日期：2024-10-04，
  
  录用日期：2024-11-25，
  
  网络出版日期：2025-01-22，
  
  纸质出版日期：2025-03-20
- 稿件说明：
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潘熙然, 张志, 雷霆. 共轭高分子在脑机接口中的应用与展望. 高分子学报, 2025, 56(3), 377-395

Pan, X. R.; Zhang, Z.; Lei, T. Application and prospects of conjugated polymers in brain-computer interfaces. Acta Polymerica Sinica, 2025, 56(3), 377-395
潘熙然, 张志, 雷霆. 共轭高分子在脑机接口中的应用与展望. 高分子学报, 2025, 56(3), 377-395 DOI： 10.11777/j.issn1000-3304.2024.24249. CSTR： 32057.14.GFZXB.2024.7324.

Pan, X. R.; Zhang, Z.; Lei, T. Application and prospects of conjugated polymers in brain-computer interfaces. Acta Polymerica Sinica, 2025, 56(3), 377-395 DOI： 10.11777/j.issn1000-3304.2024.24249. CSTR： 32057.14.GFZXB.2024.7324.

摘要

脑机接口能够在生物神经系统与电子设备之间建立双向通信，在神经科学研究、医疗康复和虚拟现实等领域发挥着重要作用. 共轭高分子具有柔性、良好的生物相容性和优异的光电特性，在柔性脑机接口中展现出巨大潜力，有望实现更高效、稳定和长期的神经信号采集与传输. 本综述总结了近年来共轭高分子材料在脑机接口领域的应用进展，介绍了导电共轭高分子电极在脑电信号采集中的应用，重点阐述了基于半导体共轭高分子的有机电化学晶体管器件在信号放大和提高信噪比等方面的独特优势. 此外，还探讨了基于共轭高分子的水凝胶材料的潜力与发展现状，并总结了该领域的发展趋势及主要挑战. 综合分析表明，共轭高分子在推动脑机接口多功能化和长期稳定监测方面具有广阔前景. 未来研究应聚焦于开发高性能共轭高分子基水凝胶材料、优化器件结构和开展系统集成，以推动柔性脑机接口技术的发展.

Abstract

Conjugated polymers

with their flexibility

biocompatibility

and excellent electrical properties

demonstrate significant potential in flexible brain-computer interfaces (BCIs)

offering prospects for more efficient

stable

and long-term neural signal acquisition and transmission. This review summarizes recent advances in applying conjugated polymers in BCIs

first introducing the use of conductive conjugated polymer electrodes for electrical signal acquisition

highlighting the the unique advantages of organic electrochemical transistor (OECT) devices based on semiconducting conjugated polymers in signal amplification and improving signal-to-noise ratio. In addition

the review explores the potential and current development of hydrogel materials derived from conjugated polymers

summarizing the trends and major challenges in this field. The review indicates that conjugated polymers hold significant potential for advancing BCI multifunctionality and ensuring long-term stable monitoring. We think future research should focus on the development of high-performance conjugated polymer-based hydrogels

device architecture optimization

and system-level integration to further advance flexible BCI technologies.

关键词

Keywords

references

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