高粘接力聚磷酸胆碱抗凝涂层的制备与性能

黄芷怡; 王琪; 杨欣; 张秋红

doi:10.11777/j.issn1000-3304.2025.25079

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高粘接力聚磷酸胆碱抗凝涂层的制备与性能

研究论文 | 更新时间：2025-06-09

- 高粘接力聚磷酸胆碱抗凝涂层的制备与性能
- Preparation and Performance of High Adhesion Poly-phosphorylcholine Anticoagulant Coating
- 高分子学报 2025年页码：1-11
- 作者机构：
  
  1.南京大学高性能高分子材料与技术教育部重点实验室南京 210023
  2.苏州银炙新材料科技有限公司苏州 215028
  3.南京大学配位化学国家重点实验室南京 210023
- 作者简介：
  
  E-mail: chemzqh@nju.edu.cn
  xin.yang@sk-silvermars.com
- 基金信息：
  
  国家自然科学基金(基金号 52473112)
- DOI：10.11777/j.issn1000-3304.2025.25079
  中图分类号：
- CSTR：32057.14.GFZXB.2025.7411
- 收稿日期：2025-03-25，
  
  录用日期：2025-05-06，
  
  网络出版日期：2025-06-09，
- 稿件说明：
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黄芷怡, 王琪, 杨欣, 张秋红. 高粘接力聚磷酸胆碱抗凝涂层的制备与性能. 高分子学报, doi: 10.11777/j.issn1000-3304.2025.25079

Huang, Z. Y.; Wang, Q.; Yang, X.; Zhang, Q. H. Preparation and performance of high adhesion poly-phosphorylcholine anticoagulant coating. Acta Polymerica Sinica, doi: 10.11777/j.issn1000-3304.2025.25079
黄芷怡, 王琪, 杨欣, 张秋红. 高粘接力聚磷酸胆碱抗凝涂层的制备与性能. 高分子学报, doi: 10.11777/j.issn1000-3304.2025.25079 DOI： CSTR： 32057.14.GFZXB.2025.7411.

Huang, Z. Y.; Wang, Q.; Yang, X.; Zhang, Q. H. Preparation and performance of high adhesion poly-phosphorylcholine anticoagulant coating. Acta Polymerica Sinica, doi: 10.11777/j.issn1000-3304.2025.25079 DOI： CSTR： 32057.14.GFZXB.2025.7411.

摘要

在血液接触式医疗器械(如体外循环系统、血管支架等)的临床应用中，现有涂层技术面临界面黏附强度与抗凝血性能的协同优化难以兼具的问题. 基于此，本研究开发了一种可交联磷酸胆碱(PC)聚合物涂层，通过分子结构设计同步实现界面强黏附强度与抗凝效果的提升. 采用浸涂/喷涂等涂覆工艺，在基底表面可形成稳定的抗凝涂层. 其分子结构中，磷酸胆碱基团通过模拟细胞膜磷脂双分子层结构赋予材料表面生物惰性，可控交联基团保障涂层界面黏附强度达3.8 MPa (玻璃基底). 动态接触角测试证明涂层表面存在组分自发迁移效应，暴露于血液环境中时，PC基团富集于界面形成仿生屏障. 体外实验表明，该涂层可使凝血时间延长72.5%，溶血率低于5% (符合国家医用材料标准). 细胞毒性评估证实材料符合生物相容性要求. 本研究为解决血液接触器械表面抗凝血改性与界面黏附强度难以兼顾的行业难题提供了思路，在植入式医疗器械领域展现出重要应用价值.

Abstract

In the clinical application of blood-contacting medical devices (such as extracorporeal circulation systems and vascular stents)

the existing coating technologies face the challenge of simultaneously achieving high interfacial adhesion strength and anticoagulant performance. Based on this

this study developed a crosslink-able phosphorylcholine (PC) polymer coating

which simultaneously enhances interfacial adhesion strength and anticoagulant effect through molecular structure design. The coating can be formed on the substrate surface by dip-coating or spray-coating processes to create a stable anticoagulant coating. In its molecular structure

the phosphocholine group imitates the phospholipid bilayer structure of the cell membrane to make the surface of the material bioinert

and the controllable cross-linked groups ensure the adhesion strength of the coating interface up to 3.8 MPa (glass substrate). The dynamic contact Angle test proved that there was a spontaneous migration effect of components on the surface of the coating. When exposed to the blood environment

PC groups were enriched at the interface to form a bionic barrier.

In vitro

experiments show that the coating can prolong the clotting time by 72.5%

and the hemolysis rate is less than 5% (in line with the national medical material standards). Cytotoxicity assessment confirmed that the material met the biocompatibility requirements. This work provides a way to solve the industry problem that it is difficult to take into account the anticoagulant modification of the surface of blood contact devices and the interface adhesion strength

and shows important application value in the f

ield of implantable medical devices.

关键词

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references

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