A novel cholesterol molecularly-imprinted polymerized organogel was prepared in present work.N-octadecyl maleamic acid (ODMA) as polymerizable gelator can self-assemble in polymerizable solvent mixture of β-hydroxyethyl methacrylate

methylacrylic acid and polyethylene glycol dimethacrylates-200 in the presence of 3-cholesteryloxycarbonylbonylpropanoic acid (COPA) as template

and ultimately turn them into organogels.The resultant organogels were subsequently polymerized by in situ UV irradiation.The molecularlyimprinting polymerized organogels were obtained after removal of the template through ethanol extracting.The images of polarized optical microscopy and field emission scanning electric microscopy of organogels indicated a number of branch-like crystallites which consisted of ODMA aggregates formed

which played an important role for the formation of stable imprinting cavities.The imprinted polymerized organogels exhibited higher adsorption efficiency(64%) for cholesterol.It was found that the adsorption capacity of the imprinted polymerized organogels depended on the contents of ODMA and COPA.For instance

the adsorption capacity increased from 15.7 mg/g to 22.9 mg/g with an increase of ODMA content from 1 wt% to 3 wt% in the matrix and increased from 16.8 mg/g to 22.2 mg/g with an increase of COPA content from 4 wt% to 7 wt%

respectively.However

the adsorption capacity decreased with further increase of ODMA and COPA contents mainly due to the high density of polymer network and interfering to the selfassembly of ODMA.