Research Progress on the Controlled Preparation of Alternating Copolyesters <italic style="font-style: italic">via</italic> Ring-opening Polymerization

Luo-yan Huang; Ji Xian; Zhao-wei Jia; Jin-cai Wu

doi:10.11777/j.issn1000-3304.2026.26114

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Research Progress on the Controlled Preparation of Alternating Copolyesters via Ring-opening Polymerization

更新时间：2026-07-09

- Research Progress on the Controlled Preparation of Alternating Copolyesters via Ring-opening Polymerization
- Acta Polymerica Sinica Pages: 1-15(2026)
- 作者机构：
  
  1.广西大学化学化工学院广西零碳智能化重点实验室广西高校低碳绿色化工新技术重点实验室南宁 530004
  2.兰州大学化学化工学院天然产物化学全国重点实验室兰州 730000
- 作者简介：
- 基金信息：
- DOI：10.11777/j.issn1000-3304.2026.26114
  CLC：
- CSTR：32057.14.GFZXB.2026.7643
- Received：25 March 2026，
  
  Accepted：26 May 2026，
  
  Online First：09 July 2026，
- 稿件说明：
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黄罗艳, 鲜记, 贾朝玮, 邬金才. 通过开环聚合反应可控制备交替共聚酯的研究进展. 高分子学报, doi: 10.11777/j.issn1000-3304.2026.26114.

Huang, L. Y.; Xian, J.; Jia, Z. W.; Wu, J. C. Research progress on the controlled preparation of alternating copolyesters via ring-opening polymerization. Acta Polymerica Sinica, doi: 10.11777/j.issn1000-3304.2026.26114.
黄罗艳, 鲜记, 贾朝玮, 邬金才. 通过开环聚合反应可控制备交替共聚酯的研究进展. 高分子学报, doi: 10.11777/j.issn1000-3304.2026.26114. DOI： CSTR： 32057.14.GFZXB.2026.7643.

Huang, L. Y.; Xian, J.; Jia, Z. W.; Wu, J. C. Research progress on the controlled preparation of alternating copolyesters via ring-opening polymerization. Acta Polymerica Sinica, doi: 10.11777/j.issn1000-3304.2026.26114. DOI： CSTR： 32057.14.GFZXB.2026.7643.

摘要

可降解聚酯因具有良好的生物来源性、生物相容性和可降解性，被视为替代传统石油基塑料的重要候选材料. 如何在环酯开环聚合过程中实现对共聚酯微观序列结构的精准调控已成为该领域亟待解决的关键科学问题. 本文系统综述了交替共聚酯序列控制的研究进展，重点归纳了2类典型策略：一是基于不对称环交酯的区域选择性开环均聚，阐明了利用电子效应与位阻效应实现酯键选择性断裂的调控机制；二是基于手性环酯的立体选择性开环共聚，总结了利用间规选择性聚合实现二分体序列控制，以及利用杂规选择性共聚实现三分体与四分体序列控制的作用规律. 进一步讨论了催化剂/引发剂在平衡单体反应活性，提升聚合体系区域选择性、立体选择性及调控聚酯拓扑结构中的关键作用，并指出精准序列调控可显著改善共聚酯的热性能、机械性能、降解行为及药物释放特性. 最后，对该领域的发展方向进行了展望.

Abstract

Biodegradable polyesters are promising alternatives to conventional petroleum-based plastics owing to their favorable bio-based origin

biocompatibility

and degradability. Achieving precise control over the microstructural sequence structure distribution of copolyesters during the ring-opening polymerization (ROP) of cyclic esters is a critical scientific challenge. To address this issue

this feature article summarizes recent advances in the sequence control of alternating copolyesters

with an emphasis on two representative strategies: (i) the regioselective ROP of asymmetric cyclic diesters

elucidating the regulatory mechanisms governing selective ester bond cleavage

via

electronic and steric effects

and (ii) the stereoselective ROP of chiral cyclic esters

the roles of syndioselective polymerization in achieving dyad sequence control

and heteroselective copolymerization in achieving triad and tetrad sequence control are summarized. Furthermore

the critical role of catalysts/initiators in balancing monomer reactivity

enhancing the regioselectivity and stereoselectivity of the polymerization system

and tailoring the polyester topology is discussed. It was further demonstrated that precise sequence control significantly improved the thermal properties

mechanical performance

degradation behavior

and drug release characteristics of copolyesters. Finally

future directions in this field are discussed.

关键词

Keywords

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State Key Laboratory of Fine Chemicals, Dalian University of Technology

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School of Applied Chemistry and Engineering, University of Science and Technology of China

Key Laboratory of Polymer Ecomaterials & Key Laboratory of Polymer Science and Technology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences

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Research Progress on the Controlled Preparation of Alternating Copolyesters via Ring-opening Polymerization

DOI：10.11777/j.issn1000-3304.2026.26114

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