物理沉积联合化学修饰构筑导管表面工程化抗菌抗血栓涂层

王一星; 龚海涛; 张国超; 喻青松; 练睿

doi:10.11777/j.issn1000-3304.2026.26074

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物理沉积联合化学修饰构筑导管表面工程化抗菌抗血栓涂层

研究论文 | 更新时间：2026-07-24

- 物理沉积联合化学修饰构筑导管表面工程化抗菌抗血栓涂层
- Physical Deposition Combined with Chemical Modification for Construction of Antithrombotic and Antibacterial Coatings on Catheter Surfaces
- 高分子学报 2026年57卷第8期页码：1667-1679
- 作者机构：
  
  1. 北京化工大学生命科学与技术学院有机无机全国重点实验室北京 100029
  2. 中日友好医院急诊科北京 100029
  3.中日友好医院普外科北京 100029
- 作者简介：
  
  E-mail: yuqs@mail.buct.edu.cn
  E-mail: lianruibaby@sina.com
- 基金信息：
  
  国家自然科学基金(基金号 ┣52203370;52373124);52422316┫
- DOI：10.11777/j.issn1000-3304.2026.26074
  中图分类号：
- CSTR：32057.14.GFZXB.2026.7618
- 收稿：2026-03-13，
  
  录用：2026-05-08，
  
  网络首发：2026-07-02，
  
  纸质出版：2026-08-20
- 稿件说明：
移动端阅览
王一星, 龚海涛, 张国超, 喻青松, 练睿. 物理沉积联合化学修饰构筑导管表面工程化抗菌抗血栓涂层. 高分子学报, ,2026, 57(8), 1667-1679.

Wang, Y. X.; Gong, H. T.; Zhang, G. C.; Yu, Q. S.; Lian, R. Physical deposition combined with chemical modification for construction of antithrombotic and antibacterial coatings on catheter surfaces. ,Acta Polymerica Sinica (in Chinese), ,2026, 57(8), 1667-1679.
王一星, 龚海涛, 张国超, 喻青松, 练睿. 物理沉积联合化学修饰构筑导管表面工程化抗菌抗血栓涂层. 高分子学报, ,2026, 57(8), 1667-1679. DOI： 10.11777/j.issn1000-3304.2026.26074. CSTR： 32057.14.GFZXB.2026.7618.

Wang, Y. X.; Gong, H. T.; Zhang, G. C.; Yu, Q. S.; Lian, R. Physical deposition combined with chemical modification for construction of antithrombotic and antibacterial coatings on catheter surfaces. ,Acta Polymerica Sinica (in Chinese), ,2026, 57(8), 1667-1679. DOI： 10.11777/j.issn1000-3304.2026.26074. CSTR： 32057.14.GFZXB.2026.7618.

摘要

针对中心静脉导管(CVC)临床应用中存在的导管相关血栓和导管相关血流感染问题，本研究受贻贝仿生黏附机制启发，在医用聚氨酯表面通过物理沉积构建富含氨基的聚多巴胺-己二胺活性基底，进而经温和的酰胺化与迈克尔加成反应，分别接枝含氟化合物与两性离子化合物，成功构建疏水与亲水2类兼具抗血栓/抗菌双功能的涂层. 体外评价表明，2类涂层不仅可显著抑制蛋白、血小板及细菌黏附，还可有效阻止血栓形成. 半体内动静脉分流与皮下感染模型也证实其优异的活体抗血栓及抗感染性能. 此外，涂层还展现出良好的生物相容性. 本研究建立的涂层制备工艺简便普适，为CVC等血液接触器械的功能化改性提供了具备临床转化潜力的新策略.

Abstract

In view of the problems of catheter-related thrombosis and catheter-related bloodstream infections arising from the clinical application of central venous catheters (CVCs)

inspired by the biomimetic adhesion mechanism of mussels

this study constructed an amino-rich polydopamine-hexamethylenediamine active substrate on the surface of medical polyurethane

via

physical deposition. Subsequently

fluorinated compounds and zwitterionic compounds were respectively grafted through mild amidation and Michael addition reactions

thereby successfully developing two types of coatings with hydrophobic and hydrophilic properties that possess dual anti-thrombotic and antibacterial functions.

In vitro

evaluations demonstrated that both coatings could significantly inhibit the adhesion of proteins

platelets and bacteria

and effectively prevent thrombus formation.

Ex vivo

arteriovenous shunt and subcutaneous infection models further validate their outstanding

in vivo

anti-thrombotic and anti-infective performance. Furthermore

the coatings exhibited favorable biocompatibility. The coating preparation method established in this study is simple and universally applicable

providing a novel strategy with promising clinical transformation

potential for the functional modification of blood-contacting devices such as CVCs.

关键词

Keywords

references

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