静电介导分子内交联规模制备Janus荧光单链纳米颗粒

屈开儒; 王妍; 杨振忠

doi:10.11777/j.issn1000-3304.2026.26124

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静电介导分子内交联规模制备Janus荧光单链纳米颗粒

研究论文 | 更新时间：2026-08-04

- 静电介导分子内交联规模制备Janus荧光单链纳米颗粒
- Scalable Synthesis of Janus Fluorescent Single-chain Nanoparticles by Electrostatics-mediated Intramolecular Crosslinking
- 高分子学报 2026年页码：1-9
- 作者机构：
  
  清华大学化学工程系高分子研究所先进材料教育部重点实验室北京 100084
- 作者简介：
  
  E-mail: yangzhenzhong@tsinghua.edu.cn
- 基金信息：
  
  国家自然科学基金(基金号 52293472)
- DOI：10.11777/j.issn1000-3304.2026.26124
  中图分类号：
- CSTR：32057.14.GFZXB.2026.7672
- 收稿：2026-04-17，
  
  录用：2026-06-23，
  
  网络首发：2026-08-04，
- 稿件说明：
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屈开儒, 王妍, 杨振忠. 静电介导分子内交联规模制备Janus荧光单链纳米颗粒. 高分子学报, doi: 10.11777/j.issn1000-3304.2026.26124.

Qu, K. R.; Wang, Y.; Yang, Z. Z. Scalable synthesis of Janus fluorescent single-chain nanoparticles by electrostatics-mediated intramolecular crosslinking. Acta Polymerica Sinica (in Chinese), doi: 10.11777/j.issn1000-3304.2026.26124.
屈开儒, 王妍, 杨振忠. 静电介导分子内交联规模制备Janus荧光单链纳米颗粒. 高分子学报, doi: 10.11777/j.issn1000-3304.2026.26124. DOI： CSTR： 32057.14.GFZXB.2026.7672.

Qu, K. R.; Wang, Y.; Yang, Z. Z. Scalable synthesis of Janus fluorescent single-chain nanoparticles by electrostatics-mediated intramolecular crosslinking. Acta Polymerica Sinica (in Chinese), doi: 10.11777/j.issn1000-3304.2026.26124. DOI： CSTR： 32057.14.GFZXB.2026.7672.

摘要

聚合物单链纳米颗粒(SCNPs)可经分子内交联制备，具有结构与组成精准分区特性，在催化、纳米医学和功能添加剂等方面具有广阔应用前景. 本研究基于静电介导的聚合物分子内交联方法，高效制备了荧光SCNP. 通过小分子羧酸与聚合物叔胺基团的动态静电作用，实现了聚合物链高浓度下动态交联，制备了SCNP，显著增强了其塌缩程度；通过紫外光诱导聚合物蒽基偶联反应形成共价键并固定其折叠结构. 其侧链四苯乙烯(TPE)单元旋转高度受阻，SCNP获得明显聚集诱导发光(AIE)特性. 选择交联两嵌段聚合物制备了蝌蚪状Janus双亲特性荧光SCNP，在界面以单颗粒层存在，为染色标记界面提供有效工具.

Abstract

Polymer single-chain nanoparticles (SCNPs) with distinctly compartmentalized physicochemical species are promising in catalysis

nanomedicine

and high-performance materials. In this work

a fluorescent SCNP and the Janus derivative were synthesized

via

electrostatics-mediated sequential dynamic and covalent intramolecular crosslinking. The dynamic interaction between the carboxylic acid groups of the modifiers and the tertiary amine groups on the polymer chain was employed for the first-step intramolecular crosslinking

enabling synthesis of compact SCNPs in concentrated solutions. These dynamically crosslinked SCNPs were subsequently fixated by covalent bonding through UV-induced coupling of anthracene groups. The compact microstructure was preserved. The rotation of pendant tetraphenylethylene (TPE) units within the SCNP was greatly restricte

d giving rise to a significantly enhanced aggregation-induced emission (AIE). Similarly

a tadpole-like Janus fluorescent SCNP was derived from the diblock copolymer

providing an effective tool for interfacial fluorescence labeling by forming a well-defined monolayer.

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references

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