基于Knoevenagel缩合反应的动态高分子材料

杨蕊竹; 丁晓亚; 朱耀威; 张箫浓; 刘焱龙; 肖春生; 陈学思

doi:10.11777/j.issn1000-3304.2026.26220

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基于Knoevenagel缩合反应的动态高分子材料

综述 | 更新时间：2026-08-07

- 基于Knoevenagel缩合反应的动态高分子材料
- Dynamic Polymer Materials Based on Knoevenagel Condensation Reaction
- 高分子学报 2026年页码：1-19
- 作者机构：
  
  1.中国科学院长春应用化学研究所高分子与技术全国重点实验室长春 130022
  2.安徽医科大学第一附属医院肿瘤免疫医药基础研究创新中心合肥 230022
  3.泰山学院化学化工学院泰安 271000
- 作者简介：
  
  肖春生，中国科学院长春应用化学研究所研究员. 2006年毕业于中国科学技术大学，获得学士学位. 2012年毕业于中国科学院长春应用化学研究所，获得博士学位. 2012年至今，在中国科学院长春应用化学研究所工作，历任助理研究员、副研究员和研究员. 主要研究方向是抗菌/抗肿瘤/抗炎活性高分子材料和组织修复水凝胶材料. 近年来，主持国家自然科学基金青年科学基金（C类）、（B类）、面上项目和吉林省科技厅重点研发等项目10余项. 在CCS Chem.，Adv. Mater.等国际期刊上发表论文120余篇. 申请国家发明专利39项，其中已获授权25项. 担任Chinese Journal of Polymer Science、《高分子学报》和《高分子通报》三刊联合青年编委.
  陈学思，中国科学院长春应用化学研究所研究员，所学术委员会主任，中国科学院院士. 1978~1982年本科就读于吉林大学化学系，获学士学位；1985~1988年硕士就读于中国科学院长春应用化学研究所，获硕士学位；1993~1997年博士就读于日本早稻田大学高分子化学系，获博士学位；1997~1999年在美国宾夕法尼亚大学医学院生物物理与生物化学系从事博士后研究，1999年至今在中国科学院长春应用化学研究所工作. 2004年获国家杰出青年科学基金资助，2019年当选中国科学院院士，2025年当选亚太材料科学院院士. 现任中国生物材料学会理事长，Polymer Science & Technology期刊主编，Science China Materials期刊副主编. 长期从事生物可降解高分子材料的基础与产业化研究，实现了聚乳酸材料在民用与医疗器械领域的产业化. 作为负责人承担了国家自然科学基金委基础科学中心（卓越研究群体）、重大、重点和国家“十四五”重点研发计划等项目. 发表学术论文千余篇，授权专利300余项. 获全国创新争先奖状、全国五一劳动奖章、中国科学院杰出科技成就奖、中国科学院科技促进发展奖科技贡献奖、中国石油和化学工业联合会技术发明一等奖、吉林省科技进步奖一等奖等奖项.
- 基金信息：
  
  国家自然科学基金委员会项目(E511011001;52222307)
- DOI：10.11777/j.issn1000-3304.2026.26220
  中图分类号：
- CSTR：32057.14.GFZXB.2026.7713
- 收稿：2026-06-22，
  
  录用：2026-07-31，
  
  网络首发：2026-08-06，
- 稿件说明：
移动端阅览
杨蕊竹, 丁晓亚, 朱耀威, 张箫浓, 刘焱龙, 肖春生, 陈学思. 基于Knoevenagel缩合反应的动态高分子材料. 高分子学报, doi: 10.11777/j.issn1000-3304.2026.26220.

Yang, R. Z.; Ding, X. Y.; Zhu, Y. W.; Zhang, X. N.; Liu, Y. L.; Xiao, C. S.; Chen, X. S. Dynamic polymer materials based on Knoevenagel condensation reaction. Acta Polymerica Sinica (in Chinese), doi: 10.11777/j.issn1000-3304.2026.26220.
杨蕊竹, 丁晓亚, 朱耀威, 张箫浓, 刘焱龙, 肖春生, 陈学思. 基于Knoevenagel缩合反应的动态高分子材料. 高分子学报, doi: 10.11777/j.issn1000-3304.2026.26220. DOI： CSTR： 32057.14.GFZXB.2026.7713.

Yang, R. Z.; Ding, X. Y.; Zhu, Y. W.; Zhang, X. N.; Liu, Y. L.; Xiao, C. S.; Chen, X. S. Dynamic polymer materials based on Knoevenagel condensation reaction. Acta Polymerica Sinica (in Chinese), doi: 10.11777/j.issn1000-3304.2026.26220. DOI： CSTR： 32057.14.GFZXB.2026.7713.

摘要

Knoevenagel缩合反应是醛或者酮与含有活泼亚甲基的化合物反应形成C＝C的经典反应，已被广泛应用于合成精细化学品、天然产物、染料和高分子材料等. 该反应不仅能够在有机溶剂中顺利进行，在水溶液中亦能在有或无催化剂条件下高效发生. 基于其温和高效的特点，近年来研究者尝试将其应用于新型高分子材料的构建. 研究发现，该反应生成的C＝C在水相和有机相中均表现出显著的动态性，这一特性使其既能用于制备可注射、自愈合的动态水凝胶，也能用于构建动态类玻璃高分子材料(Vitrimer)，已然成为动态高分子合成领域的一种新兴化学工具. 本综述主要就近些年来基于Knoevenagel缩合反应的动态高分子材料的设计和构建策略，及其在生物医学、可回收材料和生物基绿色材料等领域的应用与进展进行总结，并对该研究目前存在的挑战和应用潜力进行展望.

Abstract

The Knoevenagel condensation of aldehydes or ketones with active methylene compounds represents a classic method for carbon-carbon double bond formation in organic synthesis and has wide applications in the synthesis of fine chemicals

natural products

dyes

and polymeric materials. Notably

this reaction proceeds efficiently not only in conventional organic solvents but also in aqueous media in the presence or absence of catalysts. Benefiting from the mild and efficient characteristics

this reaction has recently been explored as a powerful platform for constructing novel polymeric materials. Emerging evidence indicates that the resultant C＝C bonds exhibit significant dynamic behavior in both aqueous and organic phases

enabling their application in the fabrication of injectable and self-healing dynamic hydrogels as well as dynamic vitrimers. Consequently

the Knoevenagel condensation has emerged as a promising chemical tool in the field of dynamic polymer synthesis. In this review

we systematically summarized recent advances in the design and construction strategies of dynamic polymeric materials based on the Knoevenagel condensation

with a particular focus on their applications in biomedicine

recyclable materials

and biomass-derived green materials. Moreover

the current challenges and future application potential of this kind of materials were also discussed and prospected.

关键词

Keywords

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