面向智能血管支架的可降解压力传感纤维

余沛文; 胡展翱; 杨怡清; 游凌森; 沈雳; 张松林; 彭慧胜; 孙雪梅

doi:10.11777/j.issn1000-3304.2026.26107

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面向智能血管支架的可降解压力传感纤维

研究论文 | 更新时间：2026-07-10

- 面向智能血管支架的可降解压力传感纤维
- Biodegradable Pressure-sensing Fiber for Smart Vascular Stents
- 高分子学报 2026年页码：1-11
- 作者机构：
  
  1.复旦大学高分子科学系与纤维电子材料与器件研究院聚合物分子工程全国重点实验室上海 200438
  2.复旦大学附属中山医院上海 200032
- 作者简介：
  
  E-mail: sunxm@fudan.edu.cn
- 基金信息：
  
  国家自然科学基金(基金号 ┣T2321003);T2596012┫;上海市科技计划项目(25CL2900505)
- DOI：10.11777/j.issn1000-3304.2026.26107
  中图分类号：
- CSTR：32057.14.GFZXB.2026.7624
- 收稿：2026-04-05，
  
  录用：2026-05-13，
  
  网络首发：2026-07-10，
- 稿件说明：
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余沛文, 胡展翱, 杨怡清, 游凌森, 沈雳, 张松林, 彭慧胜, 孙雪梅. 面向智能血管支架的可降解压力传感纤维. 高分子学报, doi: 10.11777/j.issn1000-3304.2026.26107.

Yu, P. W.; Hu, Z. A.; Yang, Y. Q.; You, L. S.; Shen, L.; Zhang, S. L.;Peng, H. S.; Sun, X. M. Biodegradable pressure-sensing fiber for smart vascular stents. Acta Polymerica Sinica (in Chinese), doi: 10.11777/j.issn1000-3304.2026.26107.
余沛文, 胡展翱, 杨怡清, 游凌森, 沈雳, 张松林, 彭慧胜, 孙雪梅. 面向智能血管支架的可降解压力传感纤维. 高分子学报, doi: 10.11777/j.issn1000-3304.2026.26107. DOI： CSTR： 32057.14.GFZXB.2026.7624.

Yu, P. W.; Hu, Z. A.; Yang, Y. Q.; You, L. S.; Shen, L.; Zhang, S. L.;Peng, H. S.; Sun, X. M. Biodegradable pressure-sensing fiber for smart vascular stents. Acta Polymerica Sinica (in Chinese), doi: 10.11777/j.issn1000-3304.2026.26107. DOI： CSTR： 32057.14.GFZXB.2026.7624.

摘要

生物可降解支架广泛应用于血管狭窄的治疗，但术后血管内再狭窄等并发症常导致局部血压升高，严重影响患者预后. 因此，对血管内压力进行连续原位监测具有重要的早期预警价值. 然而，现有压力传感器在结构适配性、服役周期和降解行为上难以与可降解支架匹配，限制了其临床应用. 为此，本研究提出了一种将压力监测与可降解性能协同设计的策略，制备了一种可与血管支架集成的可降解电容式压力传感纤维. 该传感纤维具有同轴多层结构，以胶原蛋白手术缝合线为柔性基底，通过热蒸镀金构建导电电极，并以聚柠檬酸酯作为介电层、聚己内酯作为封装层. 通过调控聚合物的组成与结构，实现了传感性能与降解速率的协同优化. 所制备的传感纤维在0~25 kPa (覆盖血管内生理压力范围)内灵敏度达0.051 kPa

-1

，并表现出良好的生物安全性. 其与可降解支架有效集成后可提供短期监测功能与协同降解特性，为构建可降解智能血管支架以及实现其它可植入医疗器械的功能化提供了新路径.

Abstract

Biodegradable stents are widely used in the treatment of vascular stenosis. However

post-implantation complications such as in-stent restenosis often lead to an increase in local blood pressure

significantly impacting patient prognosis. Therefore

continuous in situ monitoring of intravascular pressure holds significant early-warning potential. However

existing pressure sensors face challenges in terms of structural compatibility

service lifetime

and degradation behavior

limiting their clinical application. To address these challenges

this study proposed a design strategy that synergistically integrates pressure monitoring with degradable performance. A coaxial multilayer biodegradable capacitive pressure-sensing fiber was developed to match and integrate with the biodegradable stent. It was constructed using collagen surgical sutures as a flexible substrate

with conductive gold electrodes formed

via

thermal deposition

a poly(citrate) dielectric layer

and a polycaprolactone encapsulation layer. By regulating the composition and structure of the polymers

synergistic optimization of sensing performance and degradation

rate was successfully achieved. The fabricated sensing fiber demonstrated a sensitivity of 0.051 kPa

-1

within 0~25 kPa (covering the physiological intravascular pressure range) and exhibited good biocompatibility. When integrated with a biodegradable stent

it provides short-term monitoring capabilities and long-term degradability

offering a novel approach for the development of biodegradable smart vascular stents and the functionalization of other implantable medical devices.

关键词

Keywords

references

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